Butaphosphan with Cyanocobalamin
**Butaphosphan with Cyanocobalamin** is a combination nutritional supplement primarily used in large animal and production medicine. It provides a parenteral source of organic phosphorus and Vitamin B12. * **Butaphosphan**: An organic phosphorus compound that supports energy metabolism and assimilation of nutrients. * **Cyanocobalamin**: A synthetic form of Vitamin B12 essential for cellular metabolism, DNA synthesis, and red blood cell production. > **Clinical Pearl**: In dairy cattle, this combination is frequently utilized to manage metabolic demands during the periparturient period. Studies show it can increase post-partum glucose availability, decrease peripheral fat mobilization, and significantly lower the rate of hyperketonemia (subclinical ketosis) in mature cows.
Mechanism: * **Butaphosphan** → Acts as a readily available source of phosphorus, a critical structural component of **ATP (adenosine triphosphate)**, nucleic acids, and cell membranes. It supports gluconeogenesis and overall energy utilization. * **Cyanocobalamin (Vitamin B12)** → Acts as a vital coenzyme for **methylmalonyl-CoA mutase** (crucial for the metabolism of propionate into glucose in ruminants) and **methionine synthase**. * **Synergistic Effect** → Together, they enhance energy metabolism, improve post-partum glucose availability, and decrease ketone body formation by optimizing the TCA cycle and reducing peripheral fat mobilization.
Dosing by species
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Adults) · 1-2 mL per 100 lbs body weight · SC, IM, or IV · repeat daily as needed · Volumes of more than 10 mL should be split and given at separate intramuscular or subcutaneous sites.
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Calves) · 2-4 mL per 100 lbs body weight · SC, IM, or IV · repeat daily as needed
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies · 1-2 mL per 100 lbs body weight · SC, IM, or IV · repeat daily as needed · Volumes of more than 10 mL should be split and given at separate intramuscular or subcutaneous sites.
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Poultry/Turkeys) · 1-3 mL per liter of drinking water · PO · repeat daily as needed
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Adults) · 2 - 5 mL per 100 lbs body weight · SC, IM, or IV · repeat daily as needed · Volumes of more than 10 mL should be split and given at separate intramuscular or subcutaneous sites.
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Piglets) · 1-2.5 mL (total dose) per animal · SC, IM, or IV · repeat daily as needed
Doses are a clinical reference for licensed veterinary professionals. Always confirm against the current label and the individual patient.
Routes of administration
Contraindications
- Hyperphosphatemia
Adverse effects
- None noted in the monograph
Monitoring
- Serum phosphorus levels
- Resolution of clinical signs of deficiency
- Serum beta-hydroxybutyrate (BHBA) / ketone bodies in periparturient dairy cattle
Overdose
No specific information located regarding acute toxicity or overdosage.
VetSheet drug reference is intended for licensed veterinary professionals as a clinical decision-support aid, not a substitute for professional judgement or the manufacturer’s current label.