Enilconazole
**Enilconazole** is a broad-spectrum imidazole antifungal agent used primarily in veterinary medicine for the topical treatment of dermatophytosis (ringworm). **Clinical Pearl:** It is highly effective against common veterinary dermatophytes such as *Microsporum canis*, *Microsporum gypseum*, and *Trichophyton mentagrophytes*. It is typically supplied as a concentrated solution that must be diluted before application as a wash or dip.
Mechanism: Inhibition of **cytochrome P450-dependent** synthesis of **ergosterol** in fungal cells → increased cell wall permeability → leakage of cellular contents → fungal cell death.
Routes of administration
Contraindications
- Known hypersensitivity to enilconazole or other imidazoles
Adverse effects
- Mild skin irritation (rare)
- Hypersalivation or vomiting if ingested
Monitoring
- Resolution of skin lesions
- Negative fungal cultures (typically 2 consecutive negative cultures)
Overdose
Systemic toxicity is highly unlikely following topical application. Accidental ingestion of the concentrated solution may cause gastrointestinal irritation, vomiting, and hypersalivation. Treatment is symptomatic and supportive.
VetSheet drug reference is intended for licensed veterinary professionals as a clinical decision-support aid, not a substitute for professional judgement or the manufacturer’s current label.