Enilconazole
1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Also known as: Imaverol · Imazalil
Reviewed by the VetSheet Veterinary TeamUpdated Apr 5, 2026Evidence-based veterinary reference
Dosing by species
Dosing data for this drug is not yet available in the VetSheet formulary. Every other section below is complete. Consult the current product label before prescribing.
Overview
Enilconazole is a broad-spectrum imidazole antifungal agent used primarily in veterinary medicine for the topical treatment of dermatophytosis (ringworm).
Clinical Pearl: It is highly effective against common veterinary dermatophytes such as Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes. It is typically supplied as a concentrated solution that must be diluted before application as a wash or dip.
Mechanism of action
Inhibition of cytochrome P450-dependent synthesis of ergosterol in fungal cells → increased cell wall permeability → leakage of cellular contents → fungal cell death.
Safety & warnings
Contraindications
- Known hypersensitivity to enilconazole or other imidazoles
Adverse effects
- Mild skin irritation (rare)
- Hypersalivation or vomiting if ingested
Precautions
Warning: For topical use only. Must be diluted prior to use. Avoid contact with eyes. Prevent the animal from licking the treated area until completely dry.
Monitoring
- Resolution of skin lesions
- Negative fungal cultures (typically 2 consecutive negative cultures)
Pharmacokinetics
Absorption
Poorly absorbed systemically after topical application.
Distribution
Remains primarily in the stratum corneum and hair follicles.
Metabolism
Hepatic (for the small fraction absorbed).
Elimination
Feces and urine (for absorbed fraction).
Overdose
Systemic toxicity is highly unlikely following topical application. Accidental ingestion of the concentrated solution may cause gastrointestinal irritation, vomiting, and hypersalivation. Treatment is symptomatic and supportive.
Available products
Formulations
- Topical: 100 mg/ml (10%) liquid
Veterinary
- Imaverol 100 mg/ml (10%) concentrate for dip emulsion
Regulatory status
Available as a veterinary medicinal product in various EU member states.
Classified as POM-VPS (Prescription Only Medicine - Veterinarian, Pharmacist, Suitably Qualified Person).
No regulatory data for: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Storage & stability
Store in the original container at room temperature. Protect from light. Diluted solutions should typically be used within the timeframe specified on the product packaging.
Client information
This medication is a concentrated dip and must be diluted with water before use, exactly as directed by your veterinarian.
- Apply the diluted solution using a sponge or as a rinse to ensure the skin and hair coat are thoroughly soaked.
- Do not rinse the product off after application; allow it to air dry.
- Prevent your pet from licking themselves until the coat is completely dry to avoid stomach upset.
- Wash your hands thoroughly after applying the treatment.
VetSheet drug reference is intended for licensed veterinary professionals as a clinical decision-support aid, not a substitute for professional judgement or the manufacturer’s current label.