Ispaghula (Psyllium)
Ispaghula (commonly known as psyllium) is a bulk-forming laxative derived from the husks of *Plantago ovata* seeds. It is utilized in veterinary medicine to manage constipation, improve stool consistency, and increase dietary fiber intake. **Clinical Pearl:** Because it absorbs significant amounts of water to form a viscous gel, it is imperative that animals have free access to drinking water to prevent impaction.
Mechanism: Acts as a **bulk-forming agent** that absorbs water in the gastrointestinal tract → increases **faecal mass** → mechanically stimulates **peristalsis**. It is moderately fermentable in the colon, and the resultant **volatile fatty acids** exert an osmotic laxative effect.
Routes of administration
Contraindications
- Intestinal obstruction
- Fecal impaction
- Dysphagia
- Severe dehydration
Adverse effects
- Flatulence
- Abdominal bloating
- Esophageal or intestinal obstruction (if administered without adequate water)
Drug interactions
- Oral medications (general) · May delay or reduce the gastrointestinal absorption of concurrently administered oral drugs. Administer at least 2 hours apart. · moderate
Monitoring
- Stool consistency and frequency
- Hydration status
- Signs of abdominal discomfort or bloating
Overdose
Overdose is unlikely to cause systemic toxicity as the drug is not absorbed. However, excessive ingestion without adequate water may lead to **severe bloating**, **constipation**, or **gastrointestinal obstruction**.
VetSheet drug reference is intended for licensed veterinary professionals as a clinical decision-support aid, not a substitute for professional judgement or the manufacturer’s current label.