Mupirocin
Mupirocin is a topical antibiotic with a novel chemical structure unrelated to any other known class of antibacterial agents. It is primarily indicated for the management of resistant bacterial skin infections, especially those associated with **Staphylococcus** species (e.g., canine pyotraumatic dermatitis, intertrigo, callus pyoderma, and acne). Because of its unique mode of action, it lacks cross-resistance with other antibacterials. > **Clinical Warning:** Routine use of this agent cannot be advocated. In human medicine, mupirocin is strictly reserved for the eradication of MRSA within the nasal cavity, and low-level resistance is emerging. Use **only** if there are no alternative treatment options and do not use for longer than 7 days to limit the development of resistance.
Mechanism: Mupirocin blocks protein synthesis in bacteria by reversibly and specifically binding to and inhibiting **bacterial isoleucyl-tRNA synthetase** → prevents the incorporation of isoleucine into growing protein chains → halts bacterial growth and replication.
Dosing by species
- Bacterial skin infections (pyotraumatic dermatitis, intertrigo, callus pyoderma, acne) · Apply a thin layer of cream to infected areas · topical · q8h · Maximum 7 days · 10 minutes contact time is required for activity.
- Bacterial skin infections (including feline acne) · Apply a thin layer of cream to infected areas · topical · q8h · Maximum 7 days · 10 minutes contact time is required for activity.
Doses are a clinical reference for licensed veterinary professionals. Always confirm against the current label and the individual patient.
Routes of administration
Contraindications
- Patients with known renal impairment (due to potential systemic absorption of the polyethylene glycol vehicle in some ointment formulations)
- Deep puncture wounds or severe burns
Adverse effects
- Stinging sensation at the application site
- Local irritation or erythema
Monitoring
- Resolution of clinical signs of skin infection
- Signs of local irritation or hypersensitivity at the application site
Overdose
Systemic toxicity from topical overdosage is highly unlikely due to minimal absorption and rapid metabolism of any absorbed drug. Ingestion may cause mild gastrointestinal upset. **Clinical Pearl:** The primary concern with excessive application is local irritation or potential toxicity from the polyethylene glycol (PEG) base in patients with renal compromise.
VetSheet drug reference is intended for licensed veterinary professionals as a clinical decision-support aid, not a substitute for professional judgement or the manufacturer’s current label.