VetSheet

Pyridostigmine

Pyridostigmine bromide

Acetylcholinesterase inhibitor

Reviewed by the VetSheet Veterinary TeamUpdated May 30, 2026Evidence-based veterinary reference

Dosing by species

Dosing data for this drug is not yet available in the VetSheet formulary. Every other section below is complete. Consult the current product label before prescribing.

Overview

Pyridostigmine is a cholinesterase inhibitor used in veterinary medicine primarily for the treatment of acquired myasthenia gravis in dogs and cats. It works by inhibiting the breakdown of acetylcholine at the neuromuscular junction, thereby improving muscle strength and function.

Safety & warnings

Adverse effects

  • Vomiting
  • Diarrhea
  • Hypersalivation
  • Muscle tremors
  • Bradycardia

VetSheet drug reference is intended for licensed veterinary professionals as a clinical decision-support aid, not a substitute for professional judgement or the manufacturer’s current label.