Pyriprole
Also known as: Prac-tic
Reviewed by the VetSheet Veterinary TeamUpdated Apr 5, 2026Evidence-based veterinary reference
Doses are a clinical reference for licensed veterinary professionals. Always confirm against the current label and the individual patient.
Dosing by species
🌎 NA — North America🌍 EU — Europe
Dogs
| Indication | Dose | Route | Frequency | Duration | Region |
|---|---|---|---|---|---|
| Fleas and ticks | minimum dose 12.5 mg/kg | topical | q4wk | — | 🌍 EU |
- Fleas and ticks: For large dogs, the 5 ml dose should be applied in 2-3 spots.
Cats
| Indication | Dose | Route | Frequency | Duration | Region |
|---|---|---|---|---|---|
| Contraindicated | Do not use. | topical | — | — | 🌍 EU |
- Contraindicated: Strictly contraindicated in cats.
Doses are a clinical reference for licensed veterinary professionals. Always confirm against the current label and the individual patient.
Overview
Pyriprole is a phenylpyrazole antiparasitic agent used for the treatment and prevention of flea infestations (Ctenocephalides canis, C. felis) and tick prevention in dogs. It is applied topically as a spot-on solution.
Clinical Warning: Do not use on cats. Safety has not been established in pregnant and lactating females, or in dogs under 8 weeks of age or weighing less than 2 kg.
Mechanism of action
Pyriprole acts by interacting with ligand-gated (GABA) chloride channels, blocking the pre- and post-synaptic transfer of chloride ions → leading to hyperexcitation of the central nervous system and subsequent death of the parasites.
Safety & warnings
Contraindications
- Cats
- Pregnant and lactating females (safety not established)
- Dogs < 8 weeks of age
- Dogs < 2 kg body weight
Adverse effects
- Pruritus/dermatitis at application site
- Lethargy
- Ataxia
- Convulsions
- Emesis
- Diarrhoea
Precautions
Do not use on cats. Bathing is not recommended for 48 hours prior to and 24 hours after application. May be harmful to aquatic organisms; prevent access to watercourses. For large dogs, the 5 ml dose should be applied in 2-3 spots. For treatment of flea infestations, the additional use of an approved insect growth regulator is recommended.
Monitoring
- Efficacy of flea and tick control
- Application site reactions
- Neurological signs (ataxia, convulsions)
Overdose
No specific information available in the monograph. Overdose may exacerbate known adverse reactions such as neurological signs (ataxia, convulsions) and gastrointestinal upset (emesis, diarrhoea). Treat symptomatically.
Available products
Formulations
- Topical: 125 mg/ml spot-on pipettes of various sizes
Veterinary
- Prac-tic 125 mg/ml spot-on pipettes
Regulatory status
POM-V
POM-V
No regulatory data for: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Storage & stability
Normal precautions should be observed.
Client information
Apply the spot-on solution directly to your dog's skin as directed. For large dogs, apply in 2-3 different spots. Do not bathe your dog for 48 hours before or 24 hours after application.
Warning: Never use this product on cats. Keep treated dogs away from ponds and streams, as the medication is toxic to aquatic life.
VetSheet drug reference is intended for licensed veterinary professionals as a clinical decision-support aid, not a substitute for professional judgement or the manufacturer’s current label.