Acetato de calcio
Calcium Acetate
Calcium acetate
También conocido como: PhosLo · Calphron · Eliphos · Phosex · calcii acetas · acetato de calcio · kalcio acetates · kalciumacetat · kalciumasetaatti · Calcium diacetate
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Hyperphosphatemia associated with chronic renal failure | 60-90 mg/kg/day | PO | divided with meals | — | 🌎 NA |
| Hyperphosphatemia in CKD | 60-90 mg/kg/day divided | PO | divided with meals | Long-term | 🌍 EU |
- Hyperphosphatemia associated with chronic renal failure: In conjunction with a low-phosphorus diet. Give with food or mixed with food, or just prior to each meal. Individualize dose to achieve desired serum phosphorus concentrations. Decrease dose if serum calcium exceeds normal limits.
- Hyperphosphatemia in CKD: Dose must be titrated based on serum phosphorus levels. Must be given with food.
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Hyperphosphatemia associated with chronic renal failure | 60-90 mg/kg/day | PO | divided with meals | — | 🌎 NA |
| Hyperphosphatemia in CKD | 60-90 mg/kg/day divided | PO | divided with meals | Long-term | 🌍 EU |
- Hyperphosphatemia associated with chronic renal failure: In conjunction with a low-phosphorus diet. Give with food or mixed with food, or just prior to each meal. Individualize dose to achieve desired serum phosphorus concentrations. Decrease dose if serum calcium exceeds normal limits.
- Hyperphosphatemia in CKD: Dose must be titrated based on serum phosphorus levels. Must be given with food.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
El acetato de calcio es un agente quelante de fósforo oral utilizado principalmente en el manejo de la hiperfosfatemia secundaria a la enfermedad renal crónica (ERC).
Perla clínica: El acetato de calcio se considera el quelante de fosfato a base de calcio más eficaz. Se une aproximadamente al doble de fósforo por gramo de calcio elemental en comparación con el carbonato de calcio, lo que resulta en un menor riesgo de hipercalcemia iatrogénica. Además, a diferencia del citrato de calcio, no aumenta la absorción gastrointestinal de aluminio.
Mecanismo de acción
When administered with meals, calcium acetate dissociates in the gastrointestinal tract. The calcium ions then bind to dietary phosphorus in the stomach and proximal small intestine to form calcium phosphate, an insoluble complex.
Dietary Phosphorus + Calcium Acetate → Insoluble Calcium Phosphate → Excreted in feces.
This mechanism effectively reduces the gastrointestinal absorption of phosphorus, thereby lowering serum phosphorus levels. It is soluble over a wide range of pH, making it highly available for binding.
Seguridad y advertencias
Contraindicaciones
- Pre-existing hypercalcemia
Efectos adversos
- Hypercalcemia
- Gastrointestinal intolerance (nausea)
Precauciones
Warning: Do not use in patients with pre-existing hypercalcemia.
- Ca × P Product: Use with extreme caution if the serum calcium and phosphorus product exceeds 60 due to the risk of metastatic soft tissue mineralization.
- Concurrent Calcitriol: The concurrent use of calcium-based binders and calcitriol is controversial; some consider it contraindicated, while others require intensified monitoring for hypercalcemia.
- Monitoring: Adequate monitoring of serum ionized calcium and phosphorus is strictly required.
Interacciones farmacológicas
May lead to hypercalcemia; if used concomitantly, intensified monitoring for hypercalcemia is mandatory.
Not recommended; hypercalcemia induced by calcium acetate may cause serious arrhythmias in patients on digoxin.
Oral calcium can reduce the absorption of fluoroquinolones. Separate dosages by at least two hours.
Oral calcium can reduce the absorption of tetracyclines. Separate dosages by at least two hours.
Decreased absorption of levothyroxine
Monitorización
- Serum phosphorus (after a 12-hour fast)
- Serum ionized calcium
- Monitor initially at 10-14 day intervals; once 'stable', at 4-6 week intervals
Farmacocinética
Absorción
In humans, approximately 30% is absorbed when given with food. No specific pharmacokinetic information is available for dogs and cats.
Eliminación
Unabsorbed calcium and bound calcium phosphate are eliminated in the feces.
Sobredosis
Acute overdoses could potentially cause hypercalcemia.
- Management: Patients should be monitored and treated symptomatically.
- If the dosage was massive and recent, consider using standard protocols to empty the gut (e.g., emesis induction or gastric lavage, followed by activated charcoal, though charcoal does not bind minerals well).
Productos disponibles
Formulaciones
- Tablets
- Capsules
- Gelcaps
Etiquetado para humanos
- Calcium Acetate Oral Tablets: 667 mg (169 mg elemental calcium); Calphron® (Nephro-Tech); Eliphos® (Hawthorn)
- Calcium Acetate Oral Capsules & Gelcaps: 667 mg (169 mg elemental calcium); PhosLo® (Fresenius)
Estado regulador
Human approved products used off-label
POM (Prescription Only Medicine)
Sin datos reguladores para: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Store commercially available tablets, capsules, and gelcaps at room temperature (25°C); excursions are permitted to 15-30°C.
Información para el cliente
- Administración: Debe administrarse con las comidas (ya sea justo antes de comer o mezclado con el alimento) para unir eficazmente el fósforo presente en la dieta.
- Dosis adicionales: No administrar entre comidas a menos que su veterinario lo indique específicamente (esto a veces se realiza si la mascota requiere calcio adicional, pero generalmente solo se usa para quelar el fósforo de los alimentos).
- Monitoreo: Su mascota requerirá un seguimiento de laboratorio continuo (análisis de sangre) para asegurar que los niveles de calcio y fósforo se mantengan en un rango seguro.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.