Clotrimazole
Clotrimazole is a topical imidazole antifungal agent used to treat dermatophyte and yeast infections. It is often formulated as a cream or solution, and sometimes combined with corticosteroids for inflammatory fungal skin conditions. **Clinical Pearl:** It is commonly used for localized *Malassezia* dermatitis or localized dermatophytosis (ringworm) in veterinary medicine.
Mecanismo: Clotrimazole exerts its antifungal effect by inhibiting **cytochrome P450-dependent ergosterol synthesis**. Ergosterol is a vital component of the fungal cell membrane. Inhibition of ergosterol synthesis → disruption of fungal cell membrane permeability → leakage of intracellular contents → fungal cell death. It is effective against pathogenic dermatophytes, *Aspergillus* spp., and yeasts.
Vías de administración
Contraindicaciones
- Hypersensitivity to clotrimazole or other azole antifungals
Efectos adversos
- Local irritation
- Erythema
- Pruritus
Monitoreo
- Resolution of clinical signs (pruritus, erythema, alopecia)
- Fungal culture or cytology to confirm clearance of infection
Sobredosis
Overdose is highly unlikely with topical application. Ingestion of large amounts of cream or solution may cause mild gastrointestinal upset (vomiting, hypersalivation, diarrhea).
La referencia de fármacos de VetSheet está destinada a médicos veterinarios como apoyo a la decisión clínica; no sustituye el juicio profesional ni la información vigente del fabricante.