Sodium cromoglicate
Sodium cromoglicate (also known as cromolyn sodium) is a **mast cell stabilizer** used primarily for the management of **allergic conjunctivitis** and **allergic rhinitis**. Its action is localized to the site of application, making it effective for topical use in the eyes and respiratory tract. > **Clinical Pearl:** It is most effective when used prophylactically before exposure to known allergens, as it prevents degranulation rather than reversing the effects of already released histamine.
Mecanismo: Sodium cromoglicate works by **stabilizing mast cell membranes**. It inhibits the release of inflammatory mediators (such as **histamine** and **leukotrienes**) from sensitized mast cells by preventing calcium influx across the cell membrane. Allergen exposure → Mast cell activation blocked → **Prevention of degranulation** → Decreased allergic inflammation.
Dosificación por especie
- Allergic reactions (conjunctivitis/rhinitis) · 1-2 drops in eye or nose · Topical · q6h
- Allergic reactions (conjunctivitis/rhinitis) · 1-2 drops in eye or nose · Topical · q6h
Las dosis son una referencia clínica para médicos veterinarios. Confirme siempre con la información vigente del producto y el paciente individual.
Vías de administración
Contraindicaciones
- Known hypersensitivity to cromoglicate
Efectos adversos
- Local irritation
- Transient stinging or burning upon application
Monitoreo
- Resolution of allergic clinical signs (e.g., reduced ocular discharge, conjunctival hyperemia, or sneezing)
Sobredosis
Due to poor systemic absorption, systemic toxicity from topical or oral overdose is highly unlikely. Overdose may result in increased local irritation.
La referencia de fármacos de VetSheet está destinada a médicos veterinarios como apoyo a la decisión clínica; no sustituye el juicio profesional ni la información vigente del fabricante.