Cromolyn Sodium
Cromolyn sodium is a **mast cell stabilizing agent** used primarily in veterinary ophthalmology for the management of allergic conjunctivitis. * It lacks intrinsic vasoconstrictor, antihistaminic, cyclooxygenase (COX) inhibition, or other direct anti-inflammatory properties. * Because it prevents the release of inflammatory mediators rather than blocking their effects at the receptor level, it is most effective when used prophylactically or consistently over time. > **Clinical Pearl:** Mast cell stabilizers are generally very safe for long-term use in companion animals suffering from seasonal allergic conjunctivitis, though they may require frequent daily dosing to maintain efficacy.
Mecanismo: Cromolyn sodium acts as a **mast cell stabilizer**. Upon antigen recognition, it blocks the degranulation of sensitized mast cells → prevents the release of **histamine** and **slow-reacting substance of anaphylaxis (SRS-A)** into the surrounding ocular tissues.
Dosificación por especie
- Relief of seasonal allergy / Allergic conjunctivitis · one drop 2-6 times daily · topical ophthalmic · q4-12h
- Relief of seasonal allergy / Allergic conjunctivitis · one drop 2-6 times daily · topical ophthalmic · q4-12h
Las dosis son una referencia clínica para médicos veterinarios. Confirme siempre con la información vigente del producto y el paciente individual.
Vías de administración
Efectos adversos
- Stinging sensation upon application (low percentage of patients)
Monitoreo
- Resolution of clinical signs of allergic conjunctivitis (e.g., reduced hyperemia, chemosis, and pruritus)
Sobredosis
Overdose via the topical ophthalmic route is highly unlikely to cause systemic toxicity. Excess drops will simply wash out of the conjunctival sac.
La referencia de fármacos de VetSheet está destinada a médicos veterinarios como apoyo a la decisión clínica; no sustituye el juicio profesional ni la información vigente del fabricante.