Enilconazole
**Enilconazole** is a broad-spectrum imidazole antifungal agent used primarily in veterinary medicine for the topical treatment of dermatophytosis (ringworm). **Clinical Pearl:** It is highly effective against common veterinary dermatophytes such as *Microsporum canis*, *Microsporum gypseum*, and *Trichophyton mentagrophytes*. It is typically supplied as a concentrated solution that must be diluted before application as a wash or dip.
Mecanismo: Inhibition of **cytochrome P450-dependent** synthesis of **ergosterol** in fungal cells → increased cell wall permeability → leakage of cellular contents → fungal cell death.
Vías de administración
Contraindicaciones
- Known hypersensitivity to enilconazole or other imidazoles
Efectos adversos
- Mild skin irritation (rare)
- Hypersalivation or vomiting if ingested
Monitoreo
- Resolution of skin lesions
- Negative fungal cultures (typically 2 consecutive negative cultures)
Sobredosis
Systemic toxicity is highly unlikely following topical application. Accidental ingestion of the concentrated solution may cause gastrointestinal irritation, vomiting, and hypersalivation. Treatment is symptomatic and supportive.
La referencia de fármacos de VetSheet está destinada a médicos veterinarios como apoyo a la decisión clínica; no sustituye el juicio profesional ni la información vigente del fabricante.