Erythromycin
Erythromycin is a **macrolide antibiotic** frequently utilized in veterinary ophthalmology. * **Spectrum of Activity:** Primarily effective against gram-positive organisms, with the notable exception of enterococci. * **Target Organisms:** In ophthalmic applications, it is specifically targeted towards infections caused by *Mycoplasma* spp., *Chlamydia* spp., and *Borrelia burgdorferi*. * **Clinical Utility:** Because resistance to erythromycin remains relatively limited among these specific atypical organisms, it serves as a highly valuable therapeutic option for ocular surface infections, particularly feline chlamydial and mycoplasmal conjunctivitis.
Mecanismo: Erythromycin is a bacteriostatic macrolide antibiotic. * **Mechanism:** It reversibly binds to the **50S ribosomal subunit** of susceptible microorganisms. * **Pathway:** Binding to the 50S subunit → blockade of transpeptidation and/or translocation reactions → inhibition of RNA-dependent bacterial protein synthesis → suppression of bacterial growth.
Dosificación por especie
- Ophthalmic infections (Mycoplasma, Chlamydia, Borrelia) · ½ inch strip · topical ophthalmic · three to four times daily
- Ophthalmic infections (Mycoplasma, Chlamydia, Borrelia) · ½ inch strip · topical ophthalmic · three to four times daily
Las dosis son una referencia clínica para médicos veterinarios. Confirme siempre con la información vigente del producto y el paciente individual.
Vías de administración
Contraindicaciones
- Hepatic dysfunction (especially the estolate salt)
Efectos adversos
- Gastrointestinal upset (most common)
- Cholestatic hepatitis (associated with estolate salt in humans)
Interacciones farmacológicas
- Digoxin · May enhance the absorption of digoxin from the GI tract · moderate
- Ciclosporin · Increases serum levels of ciclosporin · major
- Cisapride · Increases serum levels of cisapride, leading to potentially fatal arrhythmias · major
- Methylprednisolone · Increases serum levels of methylprednisolone · moderate
- Theophylline · Increases serum levels of theophylline · major
- Terfenadine · Increases serum levels of terfenadine, leading to potentially fatal arrhythmias · major
- Macrolides · Antagonism may occur if used in combination · major
- Lincosamides · Antagonism may occur if used in combination · major
- Chloramphenicol · Antagonism may occur if used in combination (competes for 50S binding site) · major
Monitoreo
- Gastrointestinal signs
- Hepatic function (especially if using estolate salt)
- Renal function
- Serum levels of interacting drugs (e.g., theophylline, ciclosporin)
La referencia de fármacos de VetSheet está destinada a médicos veterinarios como apoyo a la decisión clínica; no sustituye el juicio profesional ni la información vigente del fabricante.