Flumetasona
Flumethasone
6alpha, 9alpha-difluoro-16alpha methylprednisolone
También conocido como: Flucort · Cerson · Locacortene · Locortene · Lorinden · flumetasone · glumetasoni pivalas · NSC-107680
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Labeled indications (musculoskeletal conditions, dermatoses, allergic states, shock) | 0.0625-0.25 mg daily in divided doses | PO | daily in divided doses | — | 🌎 NA |
| Labeled indications | 0.0625-0.25 mg daily; may repeat | IV, IM, SC | daily | — | 🌎 NA |
| Labeled indications (joint inflammation) | 0.166-1 mg | Intra-articularly | — | — | 🌎 NA |
| Labeled indications (localized lesions) | 0.125-1 mg | Intra-lesionally | — | — | 🌎 NA |
| General anti-inflammatory/immunosuppressive | 0.06-0.25 mg once daily | IV, IM, SC, or PO | once daily | — | 🌎 NA |
- Labeled indications (musculoskeletal conditions, dermatoses, allergic states, shock): Tablets no longer marketed in the USA
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Labeled indications (acute and chronic dermatoses) | 0.03125-0.125 mg daily in divided doses | PO | daily in divided doses | — | 🌎 NA |
| Labeled indications (acute and chronic dermatoses) | 0.03125-0.125 mg. If necessary, may repeat. | IV, IM, or SC | If necessary, may repeat | — | 🌎 NA |
| General anti-inflammatory/immunosuppressive | 0.03-0.125 mg once daily | IV, IM, SC, or PO | once daily | — | 🌎 NA |
- Labeled indications (acute and chronic dermatoses): Tablets no longer marketed in the USA
Caballos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Labeled indications (musculoskeletal conditions, allergic states) | 1.25-2.5 mg daily. If necessary, the dose may be repeated. | IV, IM or intra-articular | daily | — | 🌎 NA |
| General anti-inflammatory | 1-2.5 mg/450 kg | IV or IM | — | — | 🌎 NA |
- Labeled indications (musculoskeletal conditions, allergic states): ARCI UCGFS Class 4 Drug
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
La flumetasona es un glucocorticoide fluorado de alta potencia y acción prolongada, utilizado en medicina veterinaria por sus profundas propiedades antiinflamatorias e inmunosupresoras.
Las características farmacológicas clave incluyen:
- Alta potencia: Es aproximadamente de 15 a 30 veces más potente que la hidrocortisona.
- Ausencia de actividad mineralocorticoide: No presenta efectos mineralocorticoides (retención de sodio) apreciables, lo que reduce el riesgo de edema e hipertensión en comparación con los esteroides más antiguos.
- Utilidad clínica: Es altamente eficaz para reacciones inflamatorias agudas (p. ej., hipersensibilidad a picaduras de insectos, reacciones a vacunas, shock), inflamación musculoesquelética (bursitis, miositis, osteoartritis) y diversas dermatosis agudas o crónicas.
Perla clínica: El objetivo principal de la terapia con flumetasona, al igual que con todos los corticosteroides sistémicos, es utilizar la mayor cantidad necesaria, pero la menor cantidad posible, durante el tiempo más corto posible para minimizar el riesgo de hiperadrenocorticismo iatrogénico (síndrome de Cushing) y la supresión del eje adrenal.
Mecanismo de acción
Flumethasone exerts its effects via classic genomic and non-genomic steroid pathways:
- Genomic Pathway: Free flumethasone crosses the cell membrane and binds to cytosolic glucocorticoid receptors (GR).
- The receptor-ligand complex translocates to the nucleus and binds to glucocorticoid response elements (GREs) on DNA.
- Transactivation: Upregulates the expression of anti-inflammatory proteins, notably lipocortin-1 (annexin A1). Lipocortin-1 inhibits phospholipase A2 → blocking the release of arachidonic acid from membrane phospholipids → profoundly decreasing the synthesis of pro-inflammatory prostaglandins and leukotrienes.
- Transrepression: Downregulates the expression of pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF-alpha) by inhibiting transcription factors like NF-κB and AP-1.
- Non-genomic Pathway: Rapid physicochemical interactions with cellular membranes provide immediate effects, which is particularly beneficial in shock or acute hypersensitivity states.
Seguridad y advertencias
Contraindicaciones
- Last trimester of pregnancy (may induce parturition)
- Systemic fungal infections (unless used for Addison's replacement therapy)
- Idiopathic thrombocytopenia (specifically contraindicated for IM administration)
- Known hypersensitivity to the compound
- Chronic corticosteroid therapy of systemic diseases using sustained-release injectable forms
Efectos adversos
- Polydipsia (PD), polyuria (PU), and polyphagia (PP)
- Weight gain and lipidemias
- Dull, dry haircoat and dermatological thinning
- Panting
- Gastrointestinal effects: vomiting, diarrhea, GI ulceration
- Hepatopathy: elevated liver enzymes (ALP, ALT)
- Pancreatitis
- Endocrine: activation or worsening of diabetes mellitus, iatrogenic hyperadrenocorticism (Cushingoid effects) with sustained use
- Musculoskeletal: muscle wasting, retarded growth in young animals
- Behavioral changes: depression, lethargy, viciousness
- Immunosuppression: increased susceptibility to infections
Precauciones
Tapering Required: Animals that have received systemic glucocorticoids (other than short 'burst' therapy) must be tapered off slowly to allow endogenous ACTH and corticosteroid function to recover.
Stress Dosing: If an animal undergoes a 'stressor' (e.g., surgery, trauma, illness) during the tapering process or before normal adrenal/pituitary function resumes, additional glucocorticoids should be administered.
Pregnancy Warning: Corticosteroid therapy may induce parturition in large animal species during the latter stages of pregnancy. Categorized as Class C for canine and feline pregnancy (use cautiously as a last resort when benefits clearly outweigh risks).
Interacciones farmacológicas
Administered concomitantly with glucocorticoids may cause hypokalemia
In patients with myasthenia gravis, concomitant administration may lead to profound muscle weakness. Discontinue anticholinesterase at least 24 hours prior if possible.
Glucocorticoids may reduce salicylate blood levels
May increase the metabolism of glucocorticoids and decrease flumethasone blood levels
Glucocorticoids may inhibit the hepatic metabolism of cyclophosphamide; dosage adjustments may be required
Concomitant administration may increase the blood levels of each by mutually inhibiting hepatic metabolism
Flumethasone may decrease diazepam levels
Administered concomitantly with glucocorticoids may cause hypokalemia
May reduce flumethasone blood levels
Insulin requirements may increase in patients receiving glucocorticoids
May decrease the metabolism of glucocorticoids and increase flumethasone blood levels; ketoconazole may induce adrenal insufficiency when glucocorticoids are withdrawn
May decrease the metabolism of glucocorticoids and increase flumethasone blood levels
May alter the metabolism of steroids; higher than usual doses of steroids may be necessary to treat mitotane-induced adrenal insufficiency
Administration of ulcerogenic drugs with glucocorticoids may increase the risk of gastrointestinal ulceration
May increase the metabolism of glucocorticoids and decrease flumethasone blood levels
May increase the metabolism of glucocorticoids and decrease flumethasone blood levels
Patients receiving immunosuppressive dosages should not receive live attenuated-virus vaccines (augmented virus replication); diminished immune response may occur with any vaccine
Monitorización
- Weight, appetite, and signs of edema
- Serum and/or urine electrolytes
- Total plasma proteins, albumin
- Blood glucose
- Growth and development in young animals
- ACTH stimulation test if necessary (to assess adrenal axis suppression)
Sobredosis
Short-term administration of massive dosages of glucocorticoids is unlikely to cause harmful effects. There is one reported incidence of a dog developing acute CNS effects after accidental ingestion. If acute clinical signs occur, provide supportive treatment as required.
Chronic overdosage or sustained high-dose usage leads to serious adverse effects, primarily manifesting as iatrogenic hyperadrenocorticism (Cushing's syndrome), characterized by severe polyuria/polydipsia, muscle wasting, alopecia, pot-bellied appearance, and immunosuppression.
Productos disponibles
Formulaciones
- Injection: 0.5 mg/mL solution
- Tablets (Note: Oral formulations are generally no longer marketed in the USA)
Veterinario
- Flumethasone Injection: 0.5 mg/mL in 100 mL vials; Flucort Solution (Pfizer); (Rx)
Estado regulador
Sin datos reguladores para: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Flumethasone injection should be stored at room temperature; avoid freezing.
Información para el cliente
La flumetasona es un medicamento esteroide potente utilizado para reducir rápidamente la inflamación, tratar alergias graves o controlar ciertas afecciones de la piel y las articulaciones.
- Siga las instrucciones cuidadosamente: Administre la dosis exacta prescrita. No suspenda este medicamento bruscamente sin consultar a su veterinario, ya que la retirada repentina puede causar una crisis potencialmente mortal debido a la incapacidad temporal del cuerpo para producir sus propios esteroides naturales.
- Efectos secundarios esperados: Es posible que note que su mascota bebe más agua, orina con mayor frecuencia y tiene un aumento del apetito. El jadeo también es común en perros.
- Cuándo llamar al veterinario: Comuníquese con su veterinario si los efectos secundarios se vuelven graves, si su mascota presenta vómitos, diarrea, heces oscuras/alquitranadas (un signo de úlceras estomacales), letargo extremo o cambios de comportamiento (como agresividad inusual o depresión).
- Sistema inmunológico: Debido a que este fármaco suprime el sistema inmunológico, mantenga a su mascota alejada de animales enfermos y consulte a su veterinario antes de administrar cualquier vacuna.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.