Glucosamina / Condroitín Sulfato
Glucosamine / Chondroitin Sulfate
2-amino-2-deoxy-beta-D-glucopyranose / chondroitin polysulfate
También conocido como: Cosequin · Dasuquin · Restor-A-Flex · ProMotion · Seraquin · chitosamine · NSC-758 · 2-amino-2-deoxy-beta-D-glucopyranose · G6SD-glucosamine · amino monosaccharide · chondroitin 4-sulfate · chondroitin sulfate A/B/C · CSA · sodium chondroitin sulfate · chondroitin polysulfate · CDA · CSCSC · GAG · galactosaminogluconoglycan sulfate
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Adjunctive treatment of chronic pain | 13-15 mg/kg (of the chondroitin component) PO once daily (q24h) | PO | q24h | — | 🌎 NA |
| Adjunctive treatment of cancer pain | 15-30 mg/kg (of the chondroitin component) PO once daily (q24h) for 4-6 weeks then half the dose | PO | q24h | 4-6 weeks then half dose | 🌎 NA |
| Adjunctive treatment of chronic pain | 13-15 mg/kg (of the chondroitin component) PO once daily or every other day (q24-48h) | PO | q24-48h | — | 🌎 NA |
| Dietary Supplement (Cosequin Regular Strength) - Small Dogs <25 lbs | under 10 lb.: 1/2 to 1 capsule daily; 10-24 lb.: 2 capsules daily (1 in AM; 1 in PM). Maintenance Administration (after initial 4-6 week period): under 10 lb. can often have their dosage reduced to 1/2 capsule daily or 1 capsule every other day. 10 to 24 lb. can often have their dosage reduced to 1 capsule daily. | PO | q12h-q24h | Initial 4-6 weeks, then maintenance | 🌎 NA |
| Dietary Supplement (Cosequin DS) - Medium/Large Dogs >25 lbs | 25-49 lb.: 2 capsules daily (1 in AM; 1 in PM); 50-100 lb.: 3 capsules daily (2 in AM; 1 in PM); over 100 lb.: 4 capsules daily (2 in AM; 2 in PM). Maintenance Administration (after initial 4-6 week period): dogs can have their total daily dosage gradually lowered until maintenance level is reached. | PO | Divided daily | Initial 4-6 weeks, then maintenance | 🌎 NA |
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Adjunctive treatment of cancer pain | 15-30 mg/kg (of the chondroitin component) PO once daily (q24h) for 4-6 weeks then half the dose | PO | q24h | 4-6 weeks then half dose | 🌎 NA |
| Adjunctive treatment of chronic pain | 15-20 mg/kg (of the chondroitin component) PO once daily or every other day (q24-48h) | PO | q24-48h | — | 🌎 NA |
| Dietary Supplement (Cosequin For Cats) | Initially: under 10 lb.: 1 capsule sprinkled on food daily; over 10 lb.: 2 capsules sprinkled on food daily (1 in AM/1 in PM). Maintenance Administration (after initial 4-6 week period): once desired response is obtained, capsules may be administered every other day. | PO | q24h or divided | Initial 4-6 weeks, then maintenance | 🌎 NA |
Caballos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Navicular syndrome | 16.5 grams (5 scoops) in feed twice daily | PO | q12h | — | 🌎 NA |
| Dietary Supplement (Cosequin Concentrated Powder) | Initially: for horses under 600 lb., 2 scoops in AM and 2 scoops in PM; horses 600-1,200 lb., 3 scoops in AM and 3 scoops in PM; horses over 1,200 lb., 4 scoops in AM and 4 scoops in PM. Suggested Maintenance Administration: horses under 600 lb., 1 scoop daily; horses 600-1,200 lb., 1-2 scoops daily; horses over 1,200 lb., 2 scoops daily. | PO | Divided AM/PM | Initial 2-4 weeks, then maintenance | 🌎 NA |
- Navicular syndrome: Using Cosequin Concentrated Powder
- Dietary Supplement (Cosequin Concentrated Powder): Transition Period: Do not lower amount until horse has begun to respond. Reduce total daily amount by one level scoop each week.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
La glucosamina y el condroitín sulfato son nutracéuticos (suplementos nutricionales) ampliamente utilizados, principalmente como tratamiento adyuvante para la osteoartritis y otras afecciones articulares dolorosas en perros, gatos y caballos. También se utilizan ocasionalmente para favorecer la salud de la vejiga en gatos con enfermedad del tracto urinario inferior felino (FLUTD) debido a la presencia de glucosaminoglicanos en el revestimiento protector del tracto urinario.
Perla clínica: Debido a que estos productos no están regulados por la FDA como productos farmacéuticos, la calidad, pureza y biodisponibilidad pueden variar drásticamente entre fabricantes. Se recomienda encarecidamente utilizar productos de compañías veterinarias de renombre que hayan sido sometidos a pruebas de calidad independientes y ensayos clínicos (p. ej., Cosequin®).
Aunque la eficacia clínica a veces es objeto de debate y faltan estudios definitivos a gran escala, estos suplementos se consideran generalmente muy seguros y se utilizan con frecuencia como parte de un enfoque multimodal para la salud articular y el manejo del dolor crónico.
Mecanismo de acción
These compounds work synergistically to support cartilage matrix synthesis and inhibit cartilage degradation:
- Glucosamine: Acts as a primary building block for cartilage. Chondrocytes utilize glucosamine to synthesize glycosaminoglycans (GAGs) and hyaluronan. It also regulates the synthesis of collagen and proteoglycans and exhibits mild anti-inflammatory properties by scavenging free radicals.
- Chondroitin Sulfate: Provides structural integrity to cartilage. It actively inhibits destructive enzymes (such as metalloproteinases) in joint fluid and cartilage. It also stimulates the production of GAGs and proteoglycans, and may reduce thrombi formation in the microvasculature of the joint.
Pathway: Exogenous Glucosamine + Chondroitin → Uptake by Chondrocytes → ↑ GAG & Hyaluronan Synthesis + ↓ Cartilage Degrading Enzymes → Improved Joint Fluid Viscosity & Cartilage Health.
Seguridad y advertencias
Contraindicaciones
- Known hypersensitivity to glucosamine or chondroitin
Efectos adversos
- Mild gastrointestinal upset
- Flatulence
- Stool softening or mild diarrhea
- Hypersensitivity reactions (rare, as products are derived from natural sources)
Precauciones
Use with caution in patients with bronchoconstrictive conditions (e.g., asthma), as glucosamine has been reported to exacerbate asthma symptoms in humans. Product quality varies widely; choose products with proven bioavailability. Products containing manganese could lead to manganese toxicity if given at very high dosages chronically.
Interacciones farmacológicas
Glucosamine may induce resistance to this agent by reducing its inhibition of topoisomerase II.
Glucosamine may induce resistance to this agent by reducing its inhibition of topoisomerase II.
High doses of chondroitin/glucosamine may enhance coagulation effects and theoretically increase the International Normalized Ratio (INR).
High doses potentially could enhance the effects of heparin or other drugs that affect coagulation.
Monitorización
- Clinical efficacy (improvement in mobility, reduction in pain, or improvement in urinary signs for FLUTD)
Farmacocinética
Absorción
Both glucosamine HCl and glucosamine sulfate are absorbed in the gut after the salt is cleaved in the stomach. Purified, low molecular weight chondroitin appears to be absorbed from the gut. Reported bioavailability in horses is ~25% for chondroitin sulfate and ~2% for glucosamine. In dogs, bioavailability is ~5% for chondroitin sulfate and ~12% for glucosamine.
Sobredosis
Oral overdosage is highly unlikely to cause significant systemic problems. The LD50 for the combined compound in rats is greater than 5 g/kg.
- Clinical Signs: Massive ingestions may result in gastrointestinal effects (vomiting, diarrhea). Theoretical changes in coagulation parameters could occur but have not been documented.
- Toxicity Note: Products containing manganese could lead to manganese toxicity if given in very high dosages chronically above label recommendations.
Productos disponibles
Formulaciones
- Capsules
- Chewable tablets
- Powder
- Soft chews
Veterinario
- Cosequin®
- Restor-A-Flex®
- OsteO-3®
- Arthri-Nu®
- ProMotion®
- Seraquin®
- Oste-O-Guard®
- Caniflex®
- Equi-Phar Flex®
Etiquetado para humanos
- Various over-the-counter nutritional supplements (None as FDA-approved pharmaceuticals)
Estado regulador
Sin datos reguladores para: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Check individual product labels for specific storage and expiration information. Chondroitin sulfate is extremely hygroscopic (absorbs moisture from the air). Generally, these products should be stored in tight containers at room temperature, avoiding direct sunlight.
Información para el cliente
- La paciencia es clave: El inicio de cualquier mejora clínica notable puede requerir de 2 a 6 semanas de tratamiento diario constante.
- La consistencia es importante: No cambie la marca prescrita sin consultar primero a su veterinario, ya que la calidad de los suplementos de venta libre varía drásticamente.
- Administración: Los comprimidos pueden administrarse como premio o desmenuzarse en la comida. Las cápsulas pueden abrirse y espolvorearse sobre comida húmeda o comida seca humedecida para asegurar que la mascota consuma la dosis completa.
- Efectos secundarios: Es muy poco probable que se produzcan efectos adversos, pero se han reportado molestias gastrointestinales leves (heces blandas, gases). Si esto ocurre y resulta problemático, contacte a su veterinario.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.