Hemoglobina glutamer-200 (bovina)
Hemoglobin glutamer-200 (bovine)
Polymerized bovine hemoglobin
También conocido como: Oxyglobin · HBOC-301 · HG-200 · Hemoglobin glutamer-200 · Hb200
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Labeled indications (anemia) | 10-30 mL/kg | IV | One-time dose at a rate of up to 10 mL/kg/hr | — | 🌎 NA |
| Resuscitation of trauma patients in shock with or without hemorrhage | 3-5 mL/kg | IV | Once | — | 🌎 NA |
| To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction | 7-10 mL/kg or 30 mL/kg | IV | q12h (for 7-10 mL/kg dose) | 48-72 hours (for 30 mL/kg dose) | 🌎 NA |
| As an option to provide oxygen carrying capacity in the trauma patient | 10-15 mL/kg | IV | Given over several hours | — | 🌎 NA |
| As a vasopressor once there is adequate intravascular volume in trauma patients | 3-5 mL/kg | IV | Once | — | 🌎 NA |
- Labeled indications (anemia): Do not administer with other fluids or drugs via the same infusion set.
- Resuscitation of trauma patients in shock with or without hemorrhage: With concurrent crystalloid at 1/2 to 2 times maintenance.
- To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction: 7-10 mL/kg maintains Hb >3.5 g/dL; 30 mL/kg provides support for 48-72h.
- As an option to provide oxygen carrying capacity in the trauma patient: Care must be taken not to cause fluid overload.
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| As an option to provide oxygen carrying capacity in the trauma patient | 2.5-10 mL/kg | IV | Given over several hours | — | 🌎 NA |
- As an option to provide oxygen carrying capacity in the trauma patient: Care must be taken not to cause fluid overload especially in cats.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
Hemoglobina glutamer-200 (bovina) es un producto de hemoglobina bovina polimerizada semisintética utilizado principalmente como un fluido transportador de oxígeno y un potente coloide en medicina veterinaria.
- Indicación principal: Tratamiento de la anemia (debida a hemólisis, pérdida de sangre o eritropoyesis ineficaz) cuando no se dispone de sangre entera o concentrado de glóbulos rojos, o cuando no se identifican donantes compatibles mediante pruebas cruzadas.
- Perla clínica: Es particularmente valioso en anemias regenerativas y situaciones de trauma de emergencia. Debido a que está libre de estroma y carece de membranas de glóbulos rojos, no requiere tipificación sanguínea ni pruebas cruzadas antes de su administración.
- Uso fuera de etiqueta: Se ha utilizado en gatos y en potros con isoeritrólisis neonatal, aunque se requiere extrema precaución debido a sus potentes propiedades coloidales.
Mecanismo de acción
HG-200 functions both as an oxygen carrier and a potent colloid expander:
- Oxygen Delivery: Releases oxygen to tissues similarly to endogenous hemoglobin. It shifts the oxygen dissociation curve to the right, facilitating easier oxygen offloading to hypoxic tissues.
- Microvascular Perfusion: Due to its small molecular size compared to intact RBCs, it can bypass severe arterial constrictions to oxygenate ischemic cells.
- Colloidal Effect: Acts as a potent colloid (similar to dextran 70 or hetastarch), expanding intravascular volume by increasing oncotic pressure.
- Vascular Tone: Causes significant vasoconstriction, which can increase blood pressure but may decrease cardiac output in hypovolemic states.
Seguridad y advertencias
Contraindicaciones
- Advanced cardiac disease (e.g., congestive heart failure)
- Severely impaired cardiac function
- Renal impairment with oliguria or anuria
Efectos adversos
- Discolored mucous membranes, sclera, skin (yellow, red, brown)
- Discolored urine (orange, red, brown)
- Increased central venous pressure (CVP)
- Ventricular arrhythmias (AV block, tachycardia, VPCs)
- Vomiting, diarrhea, anorexia
- Tachypnea, dyspnea, harsh lung sounds
- Pulmonary edema and pleural effusion (due to volume overload)
- Fever
- Peripheral edema
- Hemoglobinuria
Precauciones
HG-200 is a potent colloid and can cause severe vasoconstriction. Extreme care must be taken to avoid volume overload, which can lead to increased hydrostatic pressure, pulmonary edema, and pleural effusion (particularly important in cats). The volume required for fluid resuscitation is approximately 1/3 that of hetastarch. May cause immunologic reactions (IgG antibodies), though anaphylaxis is rare. Laboratory Interference: HG-200 severely impacts colorimetric laboratory tests, optical coagulation assays, and urine dipsticks. PCV and RBC counts are inaccurate measures of anemia for 24 hours post-administration due to dilutional effects.
Monitorización
- Hemoglobin levels
- Clinical signs of adequate tissue oxygenation
- Central venous pressure (CVP) and signs of circulatory overload
- Respiratory rate and effort (watch for pulmonary edema)
- Heart rate and rhythm (watch for arrhythmias)
Farmacocinética
Vida media
Absorción
Administered intravenously. Peak plasma hemoglobin concentrations increase dose-dependently (e.g., ~2.5 g/dL at 15 mL/kg).
Distribución
Remains primarily in the intravascular space where it acts as a potent colloid. Duration of effect continues for at least 24 hours.
Metabolismo
Metabolized and eliminated by the reticuloendothelial system, similar to endogenous hemoglobin.
Eliminación
Small amounts of unstabilized hemoglobin (<5%) may be excreted through the kidneys, causing red discoloration of the urine. Detectable in plasma for 5-7 days.
Sobredosis
Clinical signs of overdosage (1 to 3 times the recommended dose) include yellow-orange discoloration of skin, mucous membranes, and sclera; red-dark-green-black feces; brown-black urine; decreased appetite/thirst; vomiting; diarrhea; and decreased skin elasticity. Overdosage or excessively rapid administration (>10 mL/kg/hr) may result in severe circulatory overload (pulmonary edema, pleural effusion).
Productos disponibles
Formulaciones
- Intravenous infusion bags (60 mL, 125 mL)
Veterinario
- Hemoglobin Glutamer-200 (bovine) 13 g/dL in 60 mL and 125 mL ready-to-use infusion bags (Oxyglobin)
Estado regulador
Sin datos reguladores para: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Store at room temperature or refrigerated (2°-30°C) for up to 3 years. Do not freeze. Must remain in its foil overwrap during storage to protect the hemoglobin from converting to methemoglobin. Once removed from the overwrap, it should be used within 24 hours.
Información para el cliente
Nota importante: Este medicamento es un "sustituto sanguíneo" temporal utilizado en emergencias que ponen en peligro la vida cuando no se dispone de sangre real o esta es incompatible.
- La decoloración es normal: Las encías, la piel, los ojos y la orina de su mascota pueden volverse amarillos, naranjas, rojos o marrones. Este es un efecto inofensivo del medicamento y desaparecerá en varios días.
- Vigile problemas respiratorios: Debido a que este fluido atrae agua hacia los vasos sanguíneos, puede causar acumulación de líquido en los pulmones. Contacte a su veterinario inmediatamente si su mascota respira rápido, tose o parece tener dificultad para respirar.
- Costos y riesgos: Este es un medicamento de cuidados intensivos con costos significativos y riesgos potenciales. Su veterinario discutirá la relación riesgo-beneficio con usted antes de su uso.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.