Hidrocortisona aceponato
Hydrocortisone aceponate
También conocido como: Cortavance · Easotic · HCA · Hydrocortisone 21-acetate 17-propionate
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Pruritic inflammatory skin disease | 2 pumps of spray per 10 cm x 10 cm square of skin (delivers 1.52 μg/cm2) | topical | q24h | 7 days | 🌍 EU |
| Otitis externa | 1 pump (1 ml) per ear | topical | q24h | 5 days | 🌍 EU |
- Pruritic inflammatory skin disease: Cortavance spray
- Otitis externa: Easotic (combination product)
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| General | Dose not established | topical | unknown | unknown | 🌍 EU |
- General: Safety and efficacy not fully established in cats.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
La hidrocortisona aceponato es un corticosteroide tópico potente utilizado en medicina veterinaria principalmente para el manejo de dermatosis inflamatorias y pruriginosas, así como para la otitis externa aguda o recurrente.
Perla clínica: Debido a que está formulado como un profármaco diéster, proporciona una alta eficacia antiinflamatoria local en la piel mientras minimiza significativamente la absorción sistémica y los efectos secundarios sistémicos clásicos asociados con los glucocorticoides (como la supresión adrenal o la elevación de las enzimas hepáticas).
Mecanismo de acción
Hydrocortisone aceponate is a highly lipophilic pro-drug. Upon application, it penetrates the stratum corneum and is biotransformed by local esterases in the epidermis → hydrocortisone 17-propionate (the active form). It binds to local glucocorticoid receptors to inhibit inflammatory pathways, reducing erythema, pruritus, and swelling, while its rapid local metabolism minimizes systemic distribution.
Seguridad y advertencias
Contraindicaciones
- Ulcerated skin
- Perforated tympanic membrane (ear drum)
- Cutaneous ulcers
- Known hypersensitivity to corticosteroids
- Concurrent systemic viral or fungal infections
- Use on large surface areas for prolonged periods without veterinary supervision
Efectos adversos
- Epidermal atrophy (with protracted use)
- Aural erythema (otic preparation)
- Transient hearing loss in geriatric dogs (rare, otic preparation)
- Transient local erythema
- Skin thinning or atrophy (rare, usually only with prolonged use)
- Delayed wound healing
- Systemic glucocorticoid effects (extremely rare due to rapid metabolism)
Precauciones
Do not use on ulcerated skin or if the ear drum is perforated.
- Growth Warning: Use with caution in dogs <7 months old, as glucocorticoids are known to slow growth.
- Surface Area Limits: The total body surface treated should not exceed a surface corresponding to a treatment of two flanks (from the spine to the mammary chains, including shoulders and thighs).
- Infections: Microbial infections should be treated appropriately prior to use.
- Monitoring: Patients should be monitored appropriately during long-term use to watch for epidermal atrophy or systemic absorption.
Interacciones farmacológicas
Increased risk of local skin atrophy and potential systemic absorption
Monitorización
- Resolution of pruritus and inflammation
- Signs of epidermal atrophy (skin thinning) with prolonged use
- Liver enzyme activities (during long-term use)
- Cortisol response to ACTH stimulation (during long-term use)
- Resolution of pruritus and erythema
- Signs of local skin thinning or atrophy with prolonged use
Farmacocinética
Vida media
Absorción
Highly lipophilic; penetrates the epidermis well but systemic absorption is minimal, reducing systemic side effects.
Distribución
Primarily localized to the epidermal and dermal layers of the skin at the site of application.
Metabolismo
Biotransformed locally in the epidermis to its active form, hydrocortisone 17-propionate.
Eliminación
Cleared locally with minimal systemic circulation.
Sobredosis
Massive over-application or protracted use can result in epidermal atrophy (thinning of the skin). While systemic effects (such as increases in liver enzyme activities or depression of cortisol response to ACTH stimulation) are minimized by the pro-drug formulation, they may theoretically occur with significant overdosage or ingestion.
Productos disponibles
Formulaciones
- Topical spray: 0.584 mg/ml
- Otic suspension: 1.11 mg/ml (combined with miconazole 15.1 mg/ml and gentamicin 1505 IU/ml)
- Topical spray (0.0584%)
- Otic suspension (in combination with miconazole and gentamicin)
Veterinario
- Cortavance 76 ml spray (0.584 mg/ml)
- Easotic suspension for ears (1.11 mg/ml hydrocortisone aceponate, 15.1 mg/ml miconazole, 1505 IU/ml gentamicin)
- Cortavance 0.0584% cutaneous spray, solution for dogs
- Easotic ear drops, suspension for dogs (combination with gentamicin and miconazole)
Estado regulador
Approved for veterinary use in dogs.
POM-V classification.
Sin datos reguladores para: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Normal precautions should be observed. Store at room temperature and keep out of reach of children.
Información para el cliente
Aplique este medicamento exactamente como le indique su veterinario.
- No aplicar sobre heridas abiertas o piel ulcerada.
- Si utiliza gotas óticas, su veterinario debe confirmar que el tímpano está intacto antes de comenzar el tratamiento.
- Evite rociar cerca de los ojos o la boca.
- Lávese las manos después de aplicar el medicamento o utilice guantes.
- Comuníquese con su veterinario si nota enrojecimiento en el oído, si la piel parece inusualmente delgada o si su perro de edad avanzada parece tener dificultades para oír.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.