Ibafloxacino
Ibafloxacin
También conocido como: Ibaflin · S-25030
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Susceptible infections (dermal infections: superficial and deep pyoderma, wounds, abscesses) | 15 mg/kg PO once daily | PO | q24h | Usually a 10-day course is sufficient. In cases of deep pyoderma, reconsider treatment if sufficient improvement not seen in 21 days. | 🌎 NA |
- Susceptible infections (dermal infections: superficial and deep pyoderma, wounds, abscesses): Give at time of feeding. Reconsider treatment if no improvement after 5 days.
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Susceptible infections (dermal infections: soft tissue infections-wounds, abscesses; upper respiratory tract infections) | 15 mg/kg PO once daily | PO | q24h | Usually a 10-day course is sufficient. | 🌎 NA |
- Susceptible infections (dermal infections: soft tissue infections-wounds, abscesses; upper respiratory tract infections): Give at time of feeding. Reconsider treatment if no improvement after 5 days.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
El ibafloxacino es un antibiótico fluoroquinolónico de uso veterinario específico utilizado principalmente en Europa (no disponible en EE. UU.). Presenta una actividad bactericida dependiente de la concentración contra un amplio espectro de bacterias Gram-negativas y algunas Gram-positivas (p. ej., Enterobacteriaceae, Staphylococcus spp.).
Perla clínica: A diferencia de otras fluoroquinolonas (como la enrofloxacina o la marbofloxacina), el ibafloxacino tiene una eficacia limitada contra Pseudomonas spp., Streptococcus spp. y Proteus mirabilis.
Cabe destacar que actualmente no hay indicios de que el ibafloxacino cause toxicidad ocular/retiniana en gatos, lo cual representa una ventaja significativa sobre otros fármacos de esta clase.
Mecanismo de acción
Fluoroquinolones exert their bactericidal effect by targeting essential bacterial enzymes involved in DNA replication and transcription.
- Primary Target: Inhibits bacterial DNA-gyrase (topoisomerase II) → prevents DNA supercoiling → halts DNA synthesis.
- Secondary Target: Inhibits topoisomerase IV → interferes with the separation of interlinked replicated DNA molecules.
Ibafloxacin is metabolized into two active metabolites (8-hydroxy-ibafloxacin and 7-hydroxy-ibafloxacin), which contribute to its overall antimicrobial efficacy.
Seguridad y advertencias
Contraindicaciones
- Dogs less than 8 months of age
- Giant breed dogs less than 18 months of age
- Cats less than 8 months of age
- Known quinolone hypersensitivity
Efectos adversos
- Diarrhea
- Soft feces
- Vomiting
- Dullness
- Anorexia
- Salivation
- Elevated hepatic enzymes (rare, class effect)
- Ataxia (rare, class effect)
- Seizures (rare, class effect)
- Depression/Lethargy (rare, class effect)
- Nervousness (rare, class effect)
Precauciones
Use should be based upon susceptibility testing. Safety has not been established in pregnant cats or in lactating dogs and cats, though the UK label states it can be used during pregnancy in dogs. Use with caution in patients with central nervous system disorders.
Interacciones farmacológicas
Should not be used with NSAIDs in dogs with a history of seizures due to increased risk of CNS stimulation.
Cations may bind to ibafloxacin and prevent its gastrointestinal absorption.
Fluoroquinolones may exacerbate the nephrotoxicity of systemic cyclosporine.
May antagonize the antimicrobial activity of fluoroquinolones; concomitant use is not recommended.
Increased risk for cardiotoxicity.
May inhibit absorption of ibafloxacin; separate doses by at least 2 hours.
Ibafloxacin may increase theophylline blood levels.
Monitorización
- Clinical efficacy
- Adverse GI effects (vomiting, hypersalivation, diarrhea, anorexia)
Farmacocinética
Vida media
Absorción
Dogs: Oral bioavailability is 70-80% with peak levels at ~1.5 hours. Cats: Rapidly absorbed; food slightly delays absorption but doubles peak levels and increases AUC compared to fasted administration.
Distribución
Dogs: Volume of distribution at steady state is 1.1 L/kg. Goats: Vd is 1.65 L/kg.
Metabolismo
Presumably metabolized in the liver to at least two active metabolites: 8-hydroxy-ibafloxacin and 7-hydroxy-ibafloxacin.
Eliminación
Eliminated in both urine and feces as unchanged drug and glucuronidated metabolites. Total clearance in dogs is 8.7 mL/min/kg.
Sobredosis
Specific information is limited. It is unlikely an acute overdose would result in signs more serious than anorexia or vomiting.
- Dogs: Doses of 75 mg/kg/day (5X) were apparently well tolerated.
- Cats: Doses up to 75 mg/kg/day demonstrated salivation and vomiting. If overdose occurs in cats, ophthalmic monitoring is recommended as a precaution, despite no reported ocular toxicity.
Productos disponibles
Formulaciones
- Oral gel (3%, 7.5%)
- Tablets (30 mg, 150 mg, 300 mg, 900 mg)
Veterinario
- Ibaflin 3% Oral Gel (30 mg ibafloxacin per gram of gel; 30.9 mg/mL) in 15 mL dial syringes
- 7.5% oral gel
- Tablets: 30 mg, 150 mg, 300 mg, 900 mg
Estado regulador
Sin datos reguladores para: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
The oral gel should not be stored at temperatures more than 25°C. Once opened, it is recommended that the syringe be used within 8 weeks. Dispose of unused product once a course of treatment is completed.
Información para el cliente
- Administración: Por favor, administre este medicamento con comida (durante la alimentación).
- Finalización: Es crucial terminar el tratamiento completo prescrito, incluso si su mascota parece estar completamente curada. Suspender el tratamiento antes de tiempo puede provocar infecciones resistentes a los antibióticos.
- Efectos secundarios: Esté atento a molestias estomacales leves (vómitos, diarrea, salivación excesiva o pérdida de apetito). Si estos signos se vuelven graves o persisten, contacte a su veterinario de inmediato.
- Almacenamiento: Mantenga el gel oral a temperatura ambiente (por debajo de 25°C/77°F) y deseche cualquier resto de medicamento 8 semanas después de su apertura.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.