Mupirocin
Mupirocin is a topical antibiotic with a novel chemical structure unrelated to any other known class of antibacterial agents. It is primarily indicated for the management of resistant bacterial skin infections, especially those associated with **Staphylococcus** species (e.g., canine pyotraumatic dermatitis, intertrigo, callus pyoderma, and acne). Because of its unique mode of action, it lacks cross-resistance with other antibacterials. > **Clinical Warning:** Routine use of this agent cannot be advocated. In human medicine, mupirocin is strictly reserved for the eradication of MRSA within the nasal cavity, and low-level resistance is emerging. Use **only** if there are no alternative treatment options and do not use for longer than 7 days to limit the development of resistance.
Mecanismo: Mupirocin blocks protein synthesis in bacteria by reversibly and specifically binding to and inhibiting **bacterial isoleucyl-tRNA synthetase** → prevents the incorporation of isoleucine into growing protein chains → halts bacterial growth and replication.
Dosificación por especie
- Bacterial skin infections (pyotraumatic dermatitis, intertrigo, callus pyoderma, acne) · Apply a thin layer of cream to infected areas · topical · q8h · Maximum 7 days · 10 minutes contact time is required for activity.
- Bacterial skin infections (including feline acne) · Apply a thin layer of cream to infected areas · topical · q8h · Maximum 7 days · 10 minutes contact time is required for activity.
Las dosis son una referencia clínica para médicos veterinarios. Confirme siempre con la información vigente del producto y el paciente individual.
Vías de administración
Contraindicaciones
- Patients with known renal impairment (due to potential systemic absorption of the polyethylene glycol vehicle in some ointment formulations)
- Deep puncture wounds or severe burns
Efectos adversos
- Stinging sensation at the application site
- Local irritation or erythema
Monitoreo
- Resolution of clinical signs of skin infection
- Signs of local irritation or hypersensitivity at the application site
Sobredosis
Systemic toxicity from topical overdosage is highly unlikely due to minimal absorption and rapid metabolism of any absorbed drug. Ingestion may cause mild gastrointestinal upset. **Clinical Pearl:** The primary concern with excessive application is local irritation or potential toxicity from the polyethylene glycol (PEG) base in patients with renal compromise.
La referencia de fármacos de VetSheet está destinada a médicos veterinarios como apoyo a la decisión clínica; no sustituye el juicio profesional ni la información vigente del fabricante.