Olsalazine
Olsalazine is a dimer of **5-aminosalicylic acid (5-ASA)** used primarily for the management of colitis, particularly in patients who are sensitive to sulfasalazine. > **Clinical Warning:** Although the incidence of keratoconjunctivitis sicca (KCS) is much lower than with sulfasalazine, it remains a potential risk. Periodic Schirmer tear tests should be performed during therapy.
Mecanismo: Olsalazine is a prodrug that is cleaved by colonic bacteria → releases free **5-ASA** → exerts a local anti-inflammatory effect directly on the colonic mucosa.
Dosificación por especie
- All uses (Management of colitis) · 10-20 mg/kg · PO · q12h
Las dosis son una referencia clínica para médicos veterinarios. Confirme siempre con la información vigente del producto y el paciente individual.
Vías de administración
Contraindicaciones
- Patients sensitive to salicylates
Efectos adversos
- Keratoconjunctivitis sicca (dry eye)
Interacciones farmacológicas
- NSAIDs · Activity will be potentiated by administration of other NSAIDs · moderate
Monitoreo
- Schirmer tear tests (periodic)
- Clinical response (resolution of colitis signs)
Sobredosis
No specific information available. Overdose may exacerbate gastrointestinal signs or increase the risk of salicylate toxicity.
La referencia de fármacos de VetSheet está destinada a médicos veterinarios como apoyo a la decisión clínica; no sustituye el juicio profesional ni la información vigente del fabricante.