Pamoato de pirantel
Pyrantel Pamoate
Pyrantel pamoate
También conocido como: Strongid T · Strongid Paste · Strongid C · Nemex-2 · Drontal Plus · Heartgard Plus · Tri-Heart Plus · Virbantel · Reese's Pinworm · Pin-X · CP-10423-16 · pyrantel embonate · pirantel pamoate
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| For susceptible parasites | For dogs weighing <5 lb: 10 mg/kg (as base) PO; for dogs weighing >5 lbs: 5 mg/kg (as base) PO. Treat puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Treat lactating bitches 2-3 weeks after whelping. Do follow-up fecal 2-4 weeks after treating to determine need for retreatment. | PO | See dose | — | 🌎 NA |
| For hookworms, or roundworms | 5 mg/kg PO after meals; repeat in 7-10 days | PO | repeat in 7-10 days | — | 🌎 NA |
| Puppies | 5-10 mg/kg PO; can be repeated every 2-3 weeks until at least 12 weeks of age. | PO | every 2-3 weeks | until at least 12 weeks of age | 🌎 NA |
| For susceptible parasites | 20 mg/kg PO; be sure that liquid is well mixed before using; tablets may be broken for accurate dosing. | PO | Single dose | — | 🌎 NA |
- Puppies: Can be treated as early as 2-3 weeks of age
- For susceptible parasites: Not FDA-approved for cats but very safe and effective.
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| For susceptible parasites using combination product with praziquantel (Drontal) | Administer a minimum dose of 2.27 mg praziquantel and 9.2 mg pyrantel pamoate per pound of body weight according to the dosing tables on labeling. | PO | Single dose | — | 🌎 NA |
| Ascarids, Hookworms, Physaloptera | 5 mg/kg, PO; repeat in 2 weeks (one time only for Physaloptera) | PO | repeat in 2 weeks | — | 🌎 NA |
| For susceptible parasites | 10 mg/kg PO, repeat in 3 weeks | PO | repeat in 3 weeks | — | 🌎 NA |
| Kittens | 5-10 mg/kg PO; can be repeated every 2-3 weeks until at least 12 weeks of age. | PO | every 2-3 weeks | until at least 12 weeks of age | 🌎 NA |
- For susceptible parasites using combination product with praziquantel (Drontal): May be given directly by mouth or in a small amount of food. Do not withhold food prior to or after treatment. If reinfection occurs, treatment may be repeated.
- Kittens: Can be treated as early as 2-3 weeks of age
Pequeños mamíferos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Rabbits: For susceptible parasites | 15-10 mg/kg PO, repeat in 2-3 weeks | PO | repeat in 2-3 weeks | — | 🌎 NA |
| Llamas: For susceptible parasites | 18 mg/kg, PO for one day | PO | Single dose | 1 day | 🌎 NA |
Aves
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Psittacines: In endemic areas, outdoor breeding birds and their offspring should be routinely dewormed for ascarids | 25 mg/kg PO q2 weeks. | PO | q2 weeks | — | 🌎 NA |
| For intestinal nematodes | 100 mg/kg, PO as a single dose in psittacines and passerines | PO | Single dose | — | 🌎 NA |
Caballos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| For susceptible parasites | 6.6 mg/kg PO every 6-8 weeks for ascarid control in foals and every 4 weeks for ascarid control on some farms. For tapeworm control, double the dose (13.2 mg/kg PO) and use once to twice yearly. | PO | every 4-8 weeks or 1-2x yearly | — | 🌎 NA |
| For susceptible parasites | 6.6 mg (as base)/kg PO; 13.2 mg (as base)/kg for cestodes | PO | Single dose | — | 🌎 NA |
Ganado
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| For susceptible parasites | Pyrantel tartrate: 25 mg/kg, PO | PO | Single dose | — | 🌎 NA |
Cerdos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| To remove Ascaris suum or Oesophagostomum spp. | Pyrantel tartrate: 22 mg/kg PO (or in feed at a rate of 800 grams/ton) as a single treatment. For Ascaris suum only: in feed at a rate of 96 grams/ton (2.6 mg/kg) for 3 days. | PO | Single dose or 3 days | 1-3 days | 🌎 NA |
| For ascarids and nodular worms in potbellied pigs | 6.6 mg/kg PO | PO | Single dose | — | 🌎 NA |
- To remove Ascaris suum or Oesophagostomum spp.: Label instructions from several pyrantel tartrate premix products
Ovejas
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| For susceptible parasites | Pyrantel tartrate: 25 mg/kg, PO | PO | Single dose | — | 🌎 NA |
Cabras
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| For susceptible parasites | Pyrantel tartrate: 25 mg/kg, PO | PO | Single dose | — | 🌎 NA |
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
El pamoato de pirantel es un antihelmíntico de tipo pirimidina ampliamente utilizado y de gran seguridad, eficaz principalmente contra nematodos luminales, específicamente áscaris y anquilostomas, en diversas especies.
Debido a que la sal de pamoato se absorbe poco en el tracto gastrointestinal, alcanza altas concentraciones directamente en la luz intestinal donde residen los parásitos diana. Es un fármaco fundamental en la medicina veterinaria pediátrica (utilizado rutinariamente en cachorros y gatitos) debido a su margen de seguridad excepcionalmente amplio y a su disponibilidad en suspensiones líquidas palatables.
Perla clínica: Aunque es altamente eficaz contra áscaris y anquilostomas, las dosis estándar de pirantel son ineficaces contra tricúridos (Trichuris spp.) y la mayoría de las tenias. Sin embargo, en equinos, se utiliza una dosis doble para el control de la tenia ileocecal (Anoplocephala perfoliata). La resistencia en los estróngilos equinos y en los anquilostomas caninos (Ancylostoma caninum) es una preocupación clínica emergente.
Mecanismo de acción
Pyrantel acts as a depolarizing neuromuscular blocking agent in susceptible parasites.
- It binds selectively to nicotinic acetylcholine receptors on the somatic muscle cells of the nematode.
- This binding causes continuous depolarization and an influx of calcium → spastic paralysis of the worm.
- Paralyzed worms lose their ability to maintain attachment to the host's intestinal mucosa and are subsequently expelled alive in the feces via normal gastrointestinal peristalsis.
- It also possesses mild cholinesterase inhibitory properties, further contributing to the accumulation of acetylcholine at the parasite's neuromuscular junction.
Seguridad y advertencias
Contraindicaciones
- Severely debilitated animals
Efectos adversos
- Emesis (rare, primarily in small animals)
Precauciones
Use with caution in severely debilitated animals. The drug is considered very safe for use during pregnancy (Class A in dogs/cats) and is safe to use in nursing veterinary patients.
Interacciones farmacológicas
Increased risk for adverse effects
Because of similar mechanisms of action (and toxicity), do not use concurrently
Because of similar mechanisms of action (and toxicity), do not use concurrently
Increased risk for adverse effects
Pyrantel and piperazine have antagonistic mechanisms of action; do not use together
Monitorización
- Fecal egg count reduction testing (FECRT) for strongyle nematodes (especially in horses to monitor for resistance)
- Resolution of clinical signs of parasitism
- Routine fecal flotations 2-4 weeks post-treatment
Farmacocinética
Absorción
Pyrantel pamoate is poorly absorbed from the GI tract, allowing it to reach the lower GI in dogs, cats, and equines. Pyrantel tartrate is absorbed more readily than the pamoate salt. Pigs and dogs absorb pyrantel tartrate more so than ruminants, with peak plasma levels occurring 2-3 hours after administration.
Distribución
Acts primarily locally within the gastrointestinal lumen due to poor systemic absorption of the pamoate salt.
Metabolismo
The fraction of the drug that is absorbed is rapidly metabolized.
Eliminación
Excreted into the urine and feces.
Sobredosis
Pyrantel has a moderate to wide margin of safety.
- Dosages up to approximately 7 times the recommended dose generally result in no toxic reactions.
- In horses, doses of 20X yielded no adverse effects.
- The LD50 in mice and rats for pyrantel tartrate is 170 mg/kg; >690 mg/kg for pyrantel pamoate in dogs.
- Chronic dosing of pyrantel pamoate in dogs resulted in clinical signs when given at 50 mg/kg/day, but not at 20 mg/kg/day over 3 months.
- Clinical signs of toxicity may include increased respiratory rates, profuse sweating (in species with sweat glands), ataxia, or other cholinergic effects.
Productos disponibles
Formulaciones
- Tablets
- Oral suspension
- Oral paste
- Top dress (granules/pellets)
- Soft-gel capsules
Veterinario
- Pyrantel Pamoate Tablets: 22.7 mg, 113.5 mg (Nemex Tabs)
- Pyrantel Pamoate Oral Suspension: 4.54 mg/mL (Nemex-2)
- Pyrantel Pamoate Oral Suspension: 50 mg/mL (Strongid T)
- Pyrantel Pamoate Oral Paste: 43.9% w/w (180 mg/mL) (Strongid Paste)
- Pyrantel Tartrate 1.06% Top Dress: 4.8 grams/lb (Strongid C)
- Combination Tablets: Praziquantel/Pyrantel pamoate (Drontal for Cats)
- Combination Chewables: Praziquantel/Pyrantel pamoate (Virbantel)
- Combination Tablets: Praziquantel/Pyrantel pamoate/Febantel (Drontal Plus for Dogs)
- Combination Chewables: Ivermectin/Pyrantel (Heartgard Plus, Tri-Heart Plus)
Etiquetado para humanos
- Pyrantel Pamoate Oral Suspension: 50 mg/mL & 144 mg/mL (Reese's Pinworm, Pin-X)
- Pyrantel Soft-gel Oral Capsules: 180 mg (Pin-Rid, Reese's Pinworm)
- Pyrantel Pamoate Oral Tablets: 180 mg & 720.5 mg chewable (Reese's Pinworm, Pin-X)
Estado regulador
Sin datos reguladores para: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Pyrantel pamoate products should be stored in tight, light-resistant containers at room temperature (15-30°C) unless otherwise directed by the manufacturer.
Información para el cliente
- Agite bien las suspensiones líquidas antes de extraer la dosis, ya que el medicamento se asienta en el fondo del frasco.
- Puede administrarse directamente por vía oral o mezclado con una pequeña cantidad de comida. No es necesario restringir el alimento antes o después de administrar este medicamento.
- Es posible que observe parásitos intactos, muertos o moribundos en las heces de su mascota dentro de las 24-48 horas posteriores a la administración. Esto es normal e indica que el medicamento está funcionando.
- Este medicamento es extremadamente seguro, incluso para cachorros y gatitos muy jóvenes. Los efectos secundarios son muy raros, aunque ocasionalmente puede ocurrir vómito.
- Siga el programa de dosificación repetida indicado por su veterinario, ya que una sola dosis no elimina las etapas larvarias migratorias de los parásitos.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.