Sulfaclorpiridazina sódica
Sulfachlorpyridazine Sodium
Sulfachlorpyridazine sodium
También conocido como: Vetisulid · cluricol · sulphachlorpyridazine
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Aves
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Enteric bacterial infections (E. coli) | Mix 1/4 teaspoonful per liter of water and use as only supply of drinking water | PO | continuous | 5-10 days | 🌎 NA |
| Enteric bacterial infections (E. coli) | Mix 3/4 teaspoonsful per 2 quarts of water | PO | continuous | — | 🌎 NA |
| E. coli and coccidiosis in pigeons | 1200 mg per gallon of drinking water | PO | continuous | — | 🌎 NA |
- Enteric bacterial infections (E. coli): Using the oral powder. May be effective for many E. coli enteric infections.
- Enteric bacterial infections (E. coli): Using the oral powder. Fairly effective for enteric infections, particularly E. coli. Reserved for clients who are unable to give other medications by mouth or parenterally.
- E. coli and coccidiosis in pigeons: Very effective for E. coli and it is a good coccidiostat.
Ganado
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Diarrhea caused or complicated by E. coli in calves less than one month of age | 33-49.5 mg/kg PO, or IV twice daily | PO/IV | q12h | 1-5 days | 🌎 NA |
- Diarrhea caused or complicated by E. coli in calves less than one month of age: Suggest initiating therapy with intravenous preparation and then changing to oral if possible
Cerdos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Colibacillosis | 44-77 mg/kg PO per day (divide dose and give twice daily if treating individual animals) | PO | q12h or q24h | 1-5 days | 🌎 NA |
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
La sulfaclorpiridazina sódica es un agente antimicrobiano sulfonamídico de acción corta a intermedia y baja liposolubilidad. En medicina veterinaria, está indicado principalmente para el tratamiento de infecciones entéricas, particularmente diarreas causadas o complicadas por E. coli en terneros (menores de un mes de edad) y colibacilosis en porcinos. También se utiliza por vía parenteral como una sulfonamida de uso general en ganado bovino adulto y otras especies.
Perlas clínicas:
- Como antibiótico bacteriostático dependiente del tiempo, mantener intervalos de dosificación constantes es crucial para su eficacia.
- Aunque la resistencia a las sulfonamidas es un fenómeno creciente y generalizado, la sulfaclorpiridazina sigue siendo una herramienta valiosa para aplicaciones específicas en salud de rebaños.
- Es altamente soluble en orina a niveles de pH fisiológicos habituales, aunque la cristaluria sigue siendo un riesgo en pacientes deshidratados o aquellos con orina altamente concentrada y ácida.
Mecanismo de acción
Sulfonamides are generally bacteriostatic agents. They act as structural analogues of para-aminobenzoic acid (PABA).
- They competitively inhibit the bacterial enzyme dihydropteroate synthase.
- This blocks the incorporation of PABA into dihydropteroic acid → preventing the biosynthesis of tetrahydrofolic acid (the active form of folic acid).
- Because mammalian cells utilize preformed dietary folic acid and do not synthesize their own, they are generally unaffected by this mechanism.
- Efficacy is significantly reduced in the presence of pus, necrotic tissue, or extensive cellular debris, as these environments are rich in PABA which outcompetes the drug.
Seguridad y advertencias
Contraindicaciones
- Hypersensitivity to sulfonamides, thiazides, or sulfonylurea agents
- Severe renal impairment
- Severe hepatic impairment
Efectos adversos
- Crystalluria
- Hematuria
- Renal tubule obstruction
- Keratoconjunctivitis sicca (KCS) in dogs
- Bone marrow depression
- Hypersensitivity reactions (rashes, dermatitis)
- Focal retinitis
- Fever
- Vomiting
- Nonseptic polyarthritis
- Muscle weakness, blindness, ataxia, and collapse (with rapid IV injection)
- Tissue irritation and necrosis (with IM or SC injection)
- Temporary depression of normal cellulytic function in the ruminoreticulum
Precauciones
Caution: Use with care in patients with diminished renal or hepatic function, or urinary obstruction.
- Hydration: Ensure adequate urine flow to prevent crystalluria. Alkalinization of urine may prevent crystalluria but decreases tubular reabsorption.
- Administration: Avoid too-rapid IV injection to prevent acute neurological and muscular adverse effects. Avoid IM or SC routes due to the alkaline nature of the solution causing tissue irritation and necrosis.
- Pregnancy: Potentially teratogenic at high doses; crosses the placenta. Weigh risk vs. benefit.
- Lactation: Distributed into milk. Safe use during lactation cannot be assumed; use with caution.
- Laboratory: May cause false-positive results for urine glucose determinations when using the Benedict's method.
Interacciones farmacológicas
May decrease the oral bioavailability of sulfonamides if administered concurrently
Monitorización
- Clinical efficacy (resolution of diarrhea/infection)
- Adverse effects
- Hydration status and urine output
Farmacocinética
Absorción
Readily absorbed from the GI tract of non-ruminants. Food delays the rate, but usually not the extent of absorption. Peak levels occur within 1-2 hours in non-ruminant (and young pre-ruminant) animals. Adult ruminants may have significant delays before oral absorption.
Distribución
Well distributed throughout the body; some reach significant levels in the CSF. Highest levels in liver, kidney, and lung; lower in muscle and bone. Highly bound to serum proteins (species and drug dependent); protein-bound fraction is inactive.
Metabolismo
Principally metabolized in the liver via acetylation and glucuronidation, though extra-hepatic metabolism is also involved. Acetylated metabolites may be less soluble, increasing the risk of crystalluria.
Eliminación
Renally excreted via both tubular secretion and glomerular filtration. Protein-bound drug is not filtered. The serum half-life of sulfachlorpyridazine is approximately 1.2 hours in cattle.
Sobredosis
Acute toxicity secondary to overdoses apparently occurs only rarely in veterinary species.
- Signs of Toxicity: In addition to standard adverse effects, CNS stimulation and myelin degeneration have been noted after very high dosages.
- Treatment: Treatment is largely supportive and symptomatic. Ensure aggressive fluid therapy to maintain urine output and prevent crystalluria.
Productos disponibles
Formulaciones
- Oral powder
- Oral suspension
- Injection
- Oral boluses
Veterinario
- Sulfachlorpyridazine Sodium Oral powder: 54 grams per bottle (Vetisulid Powder)
- Sulfachlorpyridazine Sodium Oral Suspension: 50 mg/mL in 180 mL bottles (Vetisulid Oral Suspension)
Estado regulador
Sin datos reguladores para: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Injection: Store at room temperature and protect from light; avoid freezing. Oral suspension: Store at room temperature; avoid freezing. Oral boluses and powder: Store at room temperature; avoid excessive heat (above 40°C; 104°F).
Información para el cliente
- El agua es crucial: Para ayudar a reducir la posibilidad de formación de cristales de fármaco en la orina (cristaluria), asegúrese de que su animal tenga acceso libre e ilimitado a agua potable fresca en todo momento. Evite la deshidratación.
- Administración adecuada: Administre el medicamento exactamente como lo prescribió su veterinario durante todo el tratamiento, incluso si el animal parece sentirse mejor.
- Monitoreo de efectos secundarios: Comuníquese con su veterinario si nota una disminución en la micción, sangre en la orina, debilidad inusual o si la diarrea empeora.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.