Brinzolamide
Brinzolamide is a topical **carbonic anhydrase inhibitor** used primarily to control **glaucoma** in dogs and cats, either alone or in combination with other topical drugs. It is often better tolerated than dorzolamide due to its more physiological pH of 7.5. > **Clinical Pearl:** While brinzolamide is ineffective at lowering intraocular pressure in normal cats, it can successfully reduce IOP in glaucomatous cats. By contrast, dorzolamide is effective in both normal and glaucomatous cats and dogs.
Mecanismo: Brinzolamide reduces intraocular pressure (IOP) by inhibiting the enzyme **carbonic anhydrase** within the ciliary body epithelium. Inhibition of carbonic anhydrase → decreased formation of bicarbonate ions → reduced fluid transport → decreased rate of **aqueous humour production**.
Dosificación por especie
- Glaucoma · 1 drop/eye · topical · q8-12h · Can be used alone or in combination with other topical drugs.
- Glaucoma · 1 drop/eye · topical · q8-12h · Ineffective in normal cats but may reduce IOP in glaucomatous cats.
Las dosis son una referencia clínica para veterinarios colegiados. Confirme siempre con la ficha técnica vigente y el paciente individual.
Vías de administración
Contraindicaciones
- Severe hepatic impairment
- Severe renal impairment
- Uveitis (specifically for the timolol combination, as timolol causes miosis)
- Anterior lens luxation (timolol combination)
- Pupil block (timolol combination)
Efectos adversos
- Local ocular irritation
- Keratitis
- Blepharitis
- Hypokalaemia (cats, rare systemic effect)
- Metabolic acidosis (dogs, rare systemic effect)
- Bradycardia and hypotension (if using the timolol combination product)
Monitorización
- Intraocular pressure (IOP)
- Signs of local ocular irritation (keratitis, blepharitis)
- Serum potassium and acid-base status (if prolonged use or systemic signs occur)
- Heart rate and blood pressure (if using timolol combination)
Sobredosis
Excessive topical application may increase the risk of systemic absorption, potentially leading to **metabolic acidosis** or **hypokalaemia** (especially in cats). If the timolol combination is used, overdose may lead to significant **bradycardia** and **hypotension**. Treatment is supportive and symptomatic.
La referencia de fármacos de VetSheet está destinada a veterinarios colegiados como apoyo a la decisión clínica, no sustituye el juicio profesional ni la ficha técnica vigente del fabricante.