Desoxycortone pivalate
Long-acting, replacement therapy for mineralocorticoid deficiency in dogs and cats with primary hypoadrenocorticism (Addison's disease). > **Warning:** It is critical that Addison's disease is definitively diagnosed before starting treatment. > **Warning:** Any dog presenting with severe hypovolaemia, dehydration, pre-renal azotaemia, and inadequate tissue perfusion (Addisonian crisis) **must be rehydrated with intravenous fluid (saline) therapy** before starting treatment with this product. **Clinical Pearl:** Many dogs require lower doses than the authorized 2.2 mg/kg. Starting at 1.5 mg/kg SC is common, particularly in larger dogs, with final maintenance doses often ranging between 1.0 and 2.7 mg/kg. Use lower doses in patients with congestive heart disease, severe renal disease, primary hepatic failure, or oedema.
Mecanismo: Acts as a **mineralocorticoid** replacement. It binds to mineralocorticoid receptors in the distal renal tubules → increases sodium reabsorption and promotes potassium excretion → restores electrolyte balance and maintains extracellular fluid volume and blood pressure.
Dosificación por especie
- Primary hypoadrenocorticism (Addison's disease) · Initial dose 2.2 mg/kg · SC · long-acting · Long-term replacement · Experience is limited but higher doses seem to be needed.
- Primary hypoadrenocorticism (Addison's disease) · Initial dose 1.5-2.2 mg/kg (final dose can be between 1.0 and 2.7 mg/kg) · SC · long-acting (interval not specified in text) · Long-term replacement · Many authorities start at the lower dose of 1.5 mg/kg SC, particularly in larger dogs.
Las dosis son una referencia clínica para veterinarios colegiados. Confirme siempre con la ficha técnica vigente y el paciente individual.
Vías de administración
Contraindicaciones
- None strictly listed, but use with caution in congestive heart disease, severe renal disease, primary hepatic failure, or oedema
Efectos adversos
- Pain on injection (rarely repeated in the same animal)
- Polyuria
- Polydipsia
- Hypokalaemia (with overdose)
- Vomiting
- Anorexia
- Muzzle swelling
- Anaphylaxis
Interacciones farmacológicas
- Spironolactone · Aldosterone antagonist; counteracts the effects of desoxycortone · major
- Furosemide · May excessively reduce potassium levels · moderate
- Thiazides · May excessively reduce potassium levels · moderate
Monitorización
- Serum sodium and potassium levels
- Hydration status
- Renal function parameters (BUN, Creatinine)
- Clinical signs of Addison's relapse or overdosage (PU/PD)
Sobredosis
Overdoses may cause **polyuria** and **hypokalaemia**. Monitor electrolytes closely if overdose is suspected.
La referencia de fármacos de VetSheet está destinada a veterinarios colegiados como apoyo a la decisión clínica, no sustituye el juicio profesional ni la ficha técnica vigente del fabricante.