Flunixin Meglumine
3-pyridinecarboxylic acid
También conocido como: Banamine · Flumeglumine · Finadyne · FluNix D · Flunixamine · Flunixiject · Flunizine · Prevail · Suppressor · Vedagesic · Resflor Gold · Sch-14714 · 3-pyridine-carboxylic acid
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Evidencia posológica v13 auditada
Evidencia estructurada para el cálculoAnalgesic/anti-inflammatory (extra-label)
Requiere verificación veterinaria
- q24h
NA
Contexto clínico obligatorio (2)
- The combination product with florfenicol (Resflor Gold®) should not be stored above 30°C (86°F). Once the vial is entered, it should be used within 28 days. The 500 mL vial should not be punctured more than 10 times.
- All flunixin products should be stored between 2°C and 30°C (36°F-86°F). Flunixin transdermal solution should be used within 6 months of first opening. Vials for injection should be used within 28 days of first puncture, punctured a maximum of 10 times.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
Flunixin meglumine es un potente fármaco antiinflamatorio no esteroideo (AINE) de uso exclusivo veterinario, ampliamente utilizado por sus propiedades analgésicas, antiinflamatorias y antipiréticas.
- Usos principales: Está aprobado por la FDA en EE. UU. para caballos, ganado bovino y porcino. En caballos, se considera el estándar de oro analgésico para el dolor visceral asociado con el cólico y también se utiliza para trastornos musculoesqueléticos. En bovinos y porcinos, se utiliza principalmente para controlar la pirexia asociada con enfermedades respiratorias y endotoxemia.
- Uso extra-label: Aunque históricamente se utilizó en animales pequeños (perros), su uso ha sido desplazado en gran medida por AINE más nuevos y seguros, preferenciales/selectivos de COX-2 (p. ej., carprofen, meloxicam). Generalmente se considera contraindicado en gatos debido a su alta sensibilidad a la toxicidad por AINE.
- Perla clínica: El flunixin destaca especialmente por su capacidad para mejorar la hemodinámica en animales con shock séptico y su profunda eficacia contra el dolor visceral en rumiantes y equinos. Sin embargo, puede enmascarar signos conductuales y cardiopulmonares de endotoxemia o desvitalización intestinal en pacientes con cólico.
Mecanismo de acción
Flunixin meglumine is a potent, non-selective inhibitor of the cyclooxygenase (COX) enzyme system.
- Mechanism: Cell membrane phospholipids → Phospholipase A2 → Arachidonic Acid → COX-1 / COX-2 → Decreased production of prostaglandins and thromboxanes.
- By inhibiting prostaglandin synthesis, it reduces inflammation, lowers body temperature (antipyretic), and provides significant analgesia.
- Unlike some other NSAIDs, flunixin does not appreciably alter gastrointestinal motility in horses, making it highly suitable for colic management.
Seguridad y advertencias
Contraindicaciones
- Known hypersensitivity to flunixin
- Cats (generally contraindicated due to availability of safer alternatives)
- Patients with preexisting GI ulcers (e.g., Equine Gastric Ulcer Syndrome - EGUS)
- Patients with significant renal, hepatic, or hematologic diseases
- Breeding bulls (lack of reproductive safety data)
- Use to ambulate cattle intended for slaughter
Efectos adversos
- Anaphylaxis (especially after rapid IV administration in horses and cattle)
- IM injection site reactions (localized swelling, induration, stiffness, sweating, and rarely clostridial myonecrosis)
- Gastrointestinal ulceration (oral and gastric ulcers, especially with prolonged use or high doses)
- Renal ischemia and nephrotoxicity (especially in dehydrated patients, dogs, and birds)
- Hematochezia and hematuria (reported in cattle treated > 3 days)
- Hypoproteinemia and hematologic abnormalities
Precauciones
Important Warnings
- Masking of Symptoms: In horses with colic, flunixin may mask the behavioral and cardiopulmonary signs associated with endotoxemia or intestinal devitalization.
- Injection Site Risks: IM injections in horses and cattle can cause significant tissue irritation and rarely clostridial myonecrosis. Rapid IV administration can cause anaphylactic-like reactions.
- Intra-arterial Injection: Accidental intra-arterial injection may cause CNS stimulation (hysteria), ataxia, hyperventilation, and muscle weakness.
- Pregnancy: Use cautiously in pregnant animals (FDA Class C equivalent).
Interacciones farmacológicas
May decrease plasma levels of flunixin and increase the likelihood of GI adverse effects (blood loss)
May increase cyclosporine blood levels and increase the risk for nephrotoxicity
May increase serum levels of digoxin; use with caution in severe cardiac failure
Increases AUC and elimination half-life of both flunixin and enrofloxacin in dogs
May reduce the saluretic and diuretic effects of the diuretic
Serious toxicity has occurred with concomitant use; use together with extreme caution
Increased risk of synergistic nephrotoxicity
May cause a significant increase in serum levels and half-life of flunixin
May increase the risk for bleeding
Monitorización
- Analgesic, anti-inflammatory, and antipyretic efficacy
- Gastrointestinal effects (especially in dogs and horses)
- CBCs and occult blood in feces with chronic use in horses
- Renal parameters (BUN, Creatinine, USG) in susceptible species or dehydrated patients
Farmacocinética
Vida media
Absorción
Rapidly absorbed following oral administration in horses (average bioavailability 80%). Peak serum levels occur in 30 minutes. Onset of action is generally within 2 hours; peak response between 12-16 hours, and duration lasts up to 30 hours.
Distribución
Highly bound to plasma proteins (>99% cattle, 92% dogs, 87% horses). Volume of distribution ranges from approximately 0.15 L/kg in horses to 0.78 L/kg in cattle.
Metabolismo
Elimination is primarily via hepatic routes.
Eliminación
Excreted primarily via biliary routes. Detectable in equine urine for at least 48 hours after a dose.
Sobredosis
Acute overdosage should be handled by using established protocols of emptying the gut (if oral ingestion and practical/possible) and treating the patient supportively.
- Gastric Ulceration: A distinct possibility in horses that have received overdoses. Consider using prophylactic anti-ulcer medications (e.g., omeprazole) in overdosed horses.
- Renal Protection: Ensure adequate hydration and monitor renal values closely.
Productos disponibles
Formulaciones
- Injection (50 mg/mL)
- Oral Paste (1500 mg/syringe)
- Oral Granules (250 mg/sachet)
- Combination Injection (16.5 mg/mL flunixin + 300 mg/mL florfenicol)
Veterinario
- Flunixin Meglumine for Injection: 50 mg/mL in 50 mL, 100 mL and 250 mL vials
- Flunixin Meglumine Oral Paste: 1500 mg/syringe in 30 gram syringes
- Flunixin Meglumine Oral Granules: 250 mg in 10 gram sachets; 500 mg in 20 g sachets
- Flunixin 16.5 mg/mL with Florfenicol 300 mg/mL Injection (Resflor Gold)
Estado regulador
Sin datos reguladores para: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Store all flunixin products between 2-30°C (36-86°F). Do not mix flunixin meglumine injection with other drugs due to unknown compatibilities. Resflor Gold should not be stored above 30°C (86°F), should be used within 28 days of first puncture, and the 500 mL vial should not be punctured more than 10 times.
Información para el cliente
Para propietarios de mascotas y ganado
- Administración: Siga las instrucciones exactas de su veterinario. Si inyecta por vía intramuscular (IM) en caballos o perros, tenga en cuenta que puede causar dolor e inflamación. (Nota: En porcinos, la inyección IM está etiquetada específicamente solo para los músculos del cuello).
- Restricciones en animales de consumo: La vía IM es extra-label en bovinos y requiere tiempos de retiro más prolongados. No utilice flunixin para hacer que el ganado lesionado o que no puede caminar sea capaz de caminar para fines de sacrificio.
- Efectos secundarios a vigilar: Suspenda la medicación y contacte a su veterinario inmediatamente si nota signos de úlceras estomacales (pérdida de apetito, heces oscuras/alquitranadas, depresión) o cambios en la micción.
- Dosis omitidas: Si la primera dosis no controla el dolor, no administre dosis adicionales sin consultar a su veterinario, ya que aumenta el riesgo de toxicidad sin añadir beneficios.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.