Indoxacarb
Treatment of flea infestations (*Ctenocephalides felis*). Developing stages of fleas in the immediate environment are killed on contact. As indoxacarb is a pro-drug bioactivated by insect enzymes, it is very specific for insect cells. Formulations with permethrin also provide prevention of tick infestations (*Ixodes ricinus* and *Rhipicephalus sanguineus*). > **Clinical Pearl:** If ticks are present on the dog at the time of application, they may not be killed within 48 hours.
Mecanismo: Acts on **voltage-dependent sodium channels** in susceptible insects. Indoxacarb is a pro-drug bioactivated by insect enzymes → the active component has a much higher affinity for insect sodium channels → highly specific for insect cells.
Dosificación por especie
- Fleas · 15 mg/kg (equivalent to 0.077 ml/kg Activyl or 0.1 ml/ kg Activyl Tick Plus) · topical · monthly
- Fleas · 25 mg/kg (equivalent to 0.128 ml/kg Activyl) · topical · monthly · The combined formulation (with permethrin) is not authorized for cats.
Las dosis son una referencia clínica para veterinarios colegiados. Confirme siempre con la ficha técnica vigente y el paciente individual.
Vías de administración
Contraindicaciones
- Dogs and cats < 8 weeks old
- Dogs < 1.5 kg (< 1.2 kg for Activyl plus)
- Cats < 0.6 kg
- Permethrin combination products must NOT be used on cats
Efectos adversos
- Transient pruritus at the site of application
- Gastrointestinal signs (rare)
Monitorización
- Efficacy of flea/tick control
- Application site reactions
Sobredosis
No specific information provided in the monograph.
La referencia de fármacos de VetSheet está destinada a veterinarios colegiados como apoyo a la decisión clínica, no sustituye el juicio profesional ni la ficha técnica vigente del fabricante.