Nandrolone
Nandrolone is an injectable anabolic androgenic steroid historically used in veterinary medicine to promote weight gain, increase red blood cell production, and stimulate appetite in debilitated animals. **Clinical Pearl:** Its use in small animal practice has largely declined due to the availability of safer alternatives, potential for adverse effects, and strict regulatory controls regarding anabolic steroids.
Mecanismo: Binds to **testosterone receptors** (androgen receptors) → stimulates **protein synthesis** and promotes tissue building (anabolism). It also stimulates the production of erythropoietin, leading to increased red blood cell mass.
Vías de administración
Contraindicaciones
- Pregnancy
- Prostate cancer or hypertrophy
- Hepatic impairment
- Cardiac failure
Efectos adversos
- Hepatotoxicity
- Virilization in females
- Prostatic enlargement in males
- Sodium and water retention
- Behavioral changes (aggression)
Interacciones farmacológicas
- Corticosteroids · May increase the risk of edema and fluid retention · moderate
- Insulin · May decrease blood glucose levels, potentially requiring insulin dose adjustment · moderate
Monitorización
- Liver enzymes (ALT, AST, ALP)
- Red blood cell count / PCV
- Weight and body condition score
- Renal function and electrolytes
Sobredosis
Overdose may result in exacerbated side effects such as severe fluid retention, hepatotoxicity, and pronounced virilization. Treatment is largely supportive and symptomatic.
La referencia de fármacos de VetSheet está destinada a veterinarios colegiados como apoyo a la decisión clínica, no sustituye el juicio profesional ni la ficha técnica vigente del fabricante.