Nystatin
Nystatin is a broad-spectrum **polyene antifungal** agent, particularly noted for its efficacy against **Candida** species (especially *C. albicans*). It is not absorbed from the gastrointestinal tract, making it suitable for local/topical or gastrointestinal fungal infections. > **Clinical Pearl:** Because it is not absorbed systemically, oral formulations are only effective for GI candidiasis, while topical formulations are used for cutaneous or otic yeast infections (such as *Malassezia* otitis).
Mecanismo: Nystatin binds to **ergosterol**, a major component of the fungal cell membrane. This binding → forms pores in the membrane → leads to **potassium leakage** → results in the death of the fungus.
Dosificación por especie
- Topical antifungal therapy · apply to affected areas · topical · q8-12h · Until clinical resolution · Often used for otitis externa or localized cutaneous candidiasis/malassezia.
- Topical antifungal therapy · apply to affected areas · topical · q8-12h · Until clinical resolution · Often used for otitis externa or localized cutaneous candidiasis/malassezia.
Las dosis son una referencia clínica para veterinarios colegiados. Confirme siempre con la ficha técnica vigente y el paciente individual.
Vías de administración
Contraindicaciones
- Known hypersensitivity to nystatin
Efectos adversos
- Generally well tolerated due to lack of systemic absorption
- Rarely GI upset if given orally (nausea, vomiting, diarrhea)
- Mild irritation or hypersensitivity at the site of topical application (rare)
Monitorización
- Resolution of clinical signs of fungal/yeast infection
- Skin/ear cytology to confirm clearance of Malassezia or Candida
Sobredosis
Overdose is highly unlikely to cause systemic toxicity due to the lack of gastrointestinal absorption. Massive oral overdose may cause mild gastrointestinal distress (vomiting, diarrhea).
La referencia de fármacos de VetSheet está destinada a veterinarios colegiados como apoyo a la decisión clínica, no sustituye el juicio profesional ni la ficha técnica vigente del fabricante.