Piperacilina Sódica + Tazobactam
Piperacillin Sodium + Tazobactam
Piperacillin sodium/tazobactam sodium
También conocido como: Zosyn · Tazocin · CL 298741 · YTR 830H · piperacillinum · BL-P 1908 · Cl 867 · CL 227193 · T 12220 · TA 058 · Pip-Tazo · Piperacillin sodium · Tazobactam sodium
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Single-agent therapy of intra-abdominal sepsis | 50 mg/kg | IV or IM | q4-6h | 5-7 days | 🌎 NA |
| Bacterial sepsis | 3.375 grams (total dose per dog) IV q6h or 4.5 grams (total dose per dog) IV q8h | IV | q6h or q8h | 7 days | 🌎 NA |
| Life-threatening infections (e.g., Pseudomonas) | 80-100 mg/kg | IV | q8h | — | 🌍 EU |
| Life-threatening infections | 25-50 mg/kg | IV | q4-6h | — | 🌍 EU |
- Single-agent therapy of intra-abdominal sepsis: Dose extrapolated from human dosage with limited studies in dogs or cats.
- Bacterial sepsis: Total dose per dog.
- Life-threatening infections (e.g., Pseudomonas): Human paediatric dose used as a guide; administer by slow IV injection/infusion.
- Life-threatening infections: Empirical dosing.
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Single-agent therapy of intra-abdominal sepsis | 50 mg/kg | IV or IM | q4-6h | 5-7 days | 🌎 NA |
- Single-agent therapy of intra-abdominal sepsis: Dose extrapolated from human dosage with limited studies in dogs or cats.
Aves
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Susceptible infections | 100 mg/kg | IM | q8-12h | — | 🌎 NA |
| Severe polymicrobic bacteremia | 100 mg/kg | IV | q6h | — | 🌎 NA |
| Preoperative orthopedic or coelomic surgery | 100 mg/kg | IM | q12h | — | 🌎 NA |
- Susceptible infections: Reconstitute to 200 mg/mL.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
Piperacilina/Tazobactam es una penicilina potente de amplio espectro con actividad antipseudomónica, combinada con un inhibidor de beta-lactamasas.
- Broad Spectrum: Ofrece una cobertura ampliada contra muchas bacterias grampositivas, gramnegativas y anaerobias, incluyendo Pseudomonas aeruginosa.
- Clinical Use: A menudo reservado para infecciones graves que ponen en peligro la vida, terapia empírica a la espera de resultados de cultivos, o profilaxis quirúrgica que involucra infecciones mixtas aerobias/anaerobias.
- Veterinary Context: Aunque la experiencia es limitada en comparación con la medicina humana, se considera bastante segura y altamente efectiva para la sepsis intraabdominal y la bacteriemia grave.
Mecanismo de acción
- Piperacillin is a bactericidal beta-lactam antibiotic. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall → inhibits the third and last stage of bacterial cell wall synthesis → cell lysis and death.
- Tazobactam is a "suicide" inhibitor. It irreversibly binds to beta-lactamases (Richmond-Sykes types II-V) → prevents these enzymes from hydrolyzing the beta-lactam ring of piperacillin.
- Synergy: Tazobactam itself has minimal antibacterial activity, but its combination with piperacillin restores and expands piperacillin's efficacy against beta-lactamase-producing organisms.
Seguridad y advertencias
Contraindicaciones
- Patients with documented hypersensitive reactions to a beta-lactam or beta-lactamase inhibitor
- Known hypersensitivity to penicillins or cephalosporins
Efectos adversos
- Hypersensitivity reactions
- Local effects (thrombophlebitis) associated with IV injection
- Antibiotic-associated diarrhea (alterations in gut flora)
- Coagulation abnormalities (rare, particularly in renal failure)
- Neurotoxicity/seizures (at very high doses, especially with diminished renal function)
- Clostridium difficile superinfections (rare)
- Nausea
- Diarrhoea
- Skin rashes
- Pain on intramuscular injection
- Sodium overload (in susceptible patients)
Precauciones
High Sodium Content: High dosages may adversely affect patients with cardiac failure or hypernatremic conditions.
- Renal Impairment: Dosage adjustment may be required in patients with significantly decreased renal function (CrCl <40 mL/min).
- Laboratory Interference: May cause false-positive results for urine glucose (cupric sulfate methods like Clinitest), direct antiglobulin (Coombs') tests, and urine protein (sulfosalicylic acid, boiling, nitric acid, or acetic acid tests). May also falsely decrease aminoglycoside serum quantitative analysis if samples are stored prior to analysis.
Interacciones farmacológicas
Synergistic or additive activity against certain bacteria. However, penicillins can inactivate aminoglycosides in vitro and in vivo in patients in renal failure or at massive dosages. Amikacin is the most resistant to this inactivation.
Piperacillin may rarely affect platelets; increased monitoring of coagulation parameters is suggested.
Piperacillin may increase MTX serum levels.
Can reduce the renal tubular secretion of both piperacillin and tazobactam, maintaining higher systemic levels for a longer period.
Piperacillin may prolong neuromuscular blockade.
Piperacillin enhances the effects of non-depolarizing muscle relaxants.
Inactivates piperacillin if mixed in the same syringe.
Synergistic bactericidal effect against pseudomonal septicaemias when administered systemically (not mixed in vitro).
Monitorización
- Efficacy for the infection treated (CBC, clinical signs, etc.)
- Coagulation parameters (if patient is concurrently on anticoagulants)
- Clinical efficacy
- Culture and sensitivity results
- Renal function
- Electrolytes (specifically sodium) in patients with cardiac or renal impairment
Farmacocinética
Absorción
Time-dependent antibiotic. Must be administered parenterally.
Distribución
Piperacillin is distributed in milk in low concentrations. It is not known if tazobactam enters milk.
Metabolismo
Piperacillin inhibits the excretion of the tazobactam component in the dog.
Eliminación
In dogs, piperacillin reduced the renal clearance of tazobactam, presumably due to competition for tubular secretion.
Sobredosis
Single overdoses are unlikely to pose much risk, although very large overdoses may cause vomiting, diarrhea, or neurotoxicity.
- Toxicity Studies: Dogs receiving up to 800 mg/kg/day of piperacillin/tazobactam for 6 months demonstrated no serious toxic effects. Doses at 400 mg/kg/day or greater caused some transient effects to the liver (glycogen granules in the cytoplasm and increases in smooth endoplasmic reticulum in hepatocytes) that were mostly reversed after one month.
- Treatment: Treatment for overdoses, if required, is supportive.
Productos disponibles
Formulaciones
- Injection (powder for solution)
- Premixed frozen containers
- 2.25 g powder for injection (2 g piperacillin sodium + 0.25 g tazobactam)
- 4.5 g powder for injection (4 g piperacillin sodium + 0.5 g tazobactam)
Etiquetado para humanos
- Piperacillin Sodium & Tazobactam Injection (powder for solution); Zosyn®: 2.25 g, 3.375 g, 4.5 g, and 40.5 g vials (preservative free)
- Premixed frozen Galaxy containers: 3.375 g/50 mL and 4.5 g/100 mL
- Tazocin 2.25 g powder for injection
- Tazocin 4.5 g powder for injection
Estado regulador
Human authorized product used off-label under the cascade. Reserved for life-threatening infections.
Human authorized product used off-label under the cascade. Reserved for life-threatening infections.
Sin datos reguladores para: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Store injection vials at controlled room temperature (20-25°C). Reconstitute conventional vials with 5 mL of diluent per gram of piperacillin. Once reconstituted, use immediately. Discard after 24 hours if kept at room temperature or 48 hours if refrigerated. Do not freeze reconstituted vials. IV bags (50-150 mL) containing further diluted product are stable for up to 24 hours at room temperature and one week if refrigerated.
Información para el cliente
Nota: Este medicamento se reserva habitualmente para mascotas hospitalizadas con infecciones graves.
- Administration: Administrado por su veterinario mediante inyección intravenosa (IV) o intramuscular (IM).
- Safety: Generalmente muy seguro, pero informe a su veterinario si su mascota ha tenido alguna vez una reacción alérgica a la penicilina u otros antibióticos.
- Side Effects: Puede causar malestar estomacal leve o diarrea. Los efectos secundarios graves son raros, pero pueden incluir signos neurológicos a dosis extremadamente altas.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.