Pyriprole
Pyriprole is a phenylpyrazole antiparasitic agent used for the **treatment and prevention of flea infestations** (*Ctenocephalides canis*, *C. felis*) and **tick prevention** in dogs. It is applied topically as a spot-on solution. > **Clinical Warning:** Do not use on cats. Safety has not been established in pregnant and lactating females, or in dogs under 8 weeks of age or weighing less than 2 kg.
Mecanismo: Pyriprole acts by interacting with **ligand-gated (GABA) chloride channels**, blocking the pre- and post-synaptic transfer of chloride ions → leading to hyperexcitation of the central nervous system and subsequent death of the parasites.
Dosificación por especie
- Fleas and ticks · minimum dose 12.5 mg/kg · topical · q4wk · For large dogs, the 5 ml dose should be applied in 2-3 spots.
- Contraindicated · Do not use. · topical · Strictly contraindicated in cats.
Las dosis son una referencia clínica para veterinarios colegiados. Confirme siempre con la ficha técnica vigente y el paciente individual.
Vías de administración
Contraindicaciones
- Cats
- Pregnant and lactating females (safety not established)
- Dogs < 8 weeks of age
- Dogs < 2 kg body weight
Efectos adversos
- Pruritus/dermatitis at application site
- Lethargy
- Ataxia
- Convulsions
- Emesis
- Diarrhoea
Monitorización
- Efficacy of flea and tick control
- Application site reactions
- Neurological signs (ataxia, convulsions)
Sobredosis
No specific information available in the monograph. Overdose may exacerbate known adverse reactions such as neurological signs (ataxia, convulsions) and gastrointestinal upset (emesis, diarrhoea). Treat symptomatically.
La referencia de fármacos de VetSheet está destinada a veterinarios colegiados como apoyo a la decisión clínica, no sustituye el juicio profesional ni la ficha técnica vigente del fabricante.