Rabacfosadine
**Rabacfosadine** is a novel antineoplastic agent used primarily in veterinary medicine for the treatment of canine lymphoma (both B-cell and T-cell) and multiple myeloma. > **Clinical Warning:** This is a potent cytotoxic drug. It must only be prepared and administered by trained personnel following strict chemotherapeutic safety guidelines.
Mecanismo: Rabacfosadine is a **prodrug** of the nucleotide analogue **PMEG** (9-(2-phosphonylmethoxyethyl)guanine). Once converted, it acts by **inhibiting DNA polymerases** → preventing DNA synthesis → causing **cytotoxicity** and apoptosis in rapidly dividing cells, such as neoplastic lymphocytes.
Dosificación por especie
- Lymphoma (B and T cell) and multiple myeloma · 0.82-1 mg/kg · IV · once every 21 days · over 30 min · Has been used in combination with doxorubicin at weeks 0, 6, 12 as part of an alternating protocol.
Las dosis son una referencia clínica para veterinarios colegiados. Confirme siempre con la ficha técnica vigente y el paciente individual.
Vías de administración
Contraindicaciones
- Known hypersensitivity
- Pre-existing bone marrow suppression
- Liver dysfunction
- Known pulmonary disease
- Susceptibility to pulmonary fibrosis
Efectos adversos
- Myelosuppression
- Gastrointestinal adverse events (including haemorrhagic gastroenteritis)
- Liver enzyme activity elevation
- Azotaemia
- Fever
- Weight loss
- Lethargy
- Dermatological signs
- Pulmonary fibrosis
- Injected sclera
- Urinary signs (proteinuria, glycosuria)
Monitorización
- Complete Blood Count (CBC) for myelosuppression
- Liver enzyme activity
- Renal parameters (BUN, Creatinine) and Urinalysis (for proteinuria/glycosuria)
- Respiratory rate and effort (monitor for pulmonary fibrosis)
- Clinical signs of gastrointestinal toxicity
Sobredosis
Information not provided in the monograph. Due to its cytotoxic nature, overdose is likely to cause severe myelosuppression, gastrointestinal toxicity, and potentially fatal pulmonary fibrosis. Aggressive supportive care and monitoring are indicated.
La referencia de fármacos de VetSheet está destinada a veterinarios colegiados como apoyo a la decisión clínica, no sustituye el juicio profesional ni la ficha técnica vigente del fabricante.