Taurine
Taurine is a beta-amino acid that, while classically considered "non-essential" in many mammalian species, is absolutely **essential for cats** and conditionally essential for certain dog breeds. - **Feline Health**: Cats cannot synthesize adequate taurine due to low cysteinesulfinic acid decarboxylase (CSAD) activity and their obligate use of taurine for bile acid conjugation. Deficiency leads to **feline central retinal degeneration (FCRD)** and **dilated cardiomyopathy (DCM)**. - **Canine Health**: Certain breeds (e.g., American Cocker Spaniels, Golden Retrievers, Newfoundlands, Dalmatians, English Bulldogs) are predisposed to taurine-deficient DCM. - **Other Uses**: Used adjunctively for hepatic lipidosis in cats (as it is hepatoprotective and required for bile conjugation) and as a complementary therapy for seizure disorders due to its neuromodulatory effects.
Mecanismo: - **Synthesis Pathway**: Synthesized *in vivo* from **methionine** and **cysteine** via the enzyme **cysteinesulfinic acid decarboxylase (CSAD)** (a process requiring **Vitamin B6**). - **Bile Acid Conjugation**: Crucial for fat digestion. Cats use taurine almost exclusively for this process, leading to obligate loss in feces. - **Cardiac Function**: Modulates **calcium flux** across cell membranes → provides positive inotropic activity without altering the resting membrane potential, and modulates ionic currents. - **Neuromodulation**: Stabilizes neuronal membranes and exerts a **GABA-like inhibitory effect** in the CNS, which may help raise the seizure threshold and reduce seizure activity. - **Platelet Function**: Reduces platelet aggregation via calcium modulation.
Dosificación por especie
- For taurine-deficiency related cardiomyopathy · 250 mg (per cat) PO q12-24h · PO · q12-24h · Because taurine is safe and inexpensive, recommend using for any case of myocardial failure.
- Complementary therapy for seizures · 500 mg per cat PO twice daily · PO · q12h · 'May' help decrease seizure activity
- For adjunctive treatment of hepatic lipidosis · 250-500 mg/day · PO · q24h · Taurine may be hepatoprotective and is required for bile conjugation. Cats with hepatic lipidosis waste taurine in their urine.
- For taurine-deficiency related cardiomyopathy in American Cocker Spaniels · 500 mg PO q12h (with 1 gram of carnitine PO q12h) · PO · q12h
- Complementary therapy for seizures · 400 mg/40 lbs of body weight PO twice daily · PO · q12h · 'May' help decrease seizure activity
- For taurine-related cardiomyopathy · 500-1500 mg (total dose) PO per day · PO · q24h
- Dilated cardiomyopathy · 500-1000 mg PO q8-12h for dogs weighing under 25 kg and 1-2 grams PO q8-12h for dogs weighing > 25 kg · PO · q8-12h · Recommended for all American Cocker spaniels; consider in animals with DCM and cysteine/urate urolithiasis (e.g., English Bulldogs, Dalmatians); consider in golden retrievers, Newfoundlands, Portuguese water dogs.
Las dosis son una referencia clínica para veterinarios colegiados. Confirme siempre con la ficha técnica vigente y el paciente individual.
Vías de administración
Efectos adversos
- Minor GI distress
Monitorización
- Clinical efficacy (improvement in cardiac function, seizure frequency, or hepatic markers)
- Taurine levels (whole blood levels preferable to plasma/serum levels; avoid hemolysis or collection of the buffy coat as it will negate the results)
Sobredosis
Toxic potential appears to be very low. No specific acute toxicity information is available, but massive overdoses are likely to be excreted renally without significant harm.
La referencia de fármacos de VetSheet está destinada a veterinarios colegiados como apoyo a la decisión clínica, no sustituye el juicio profesional ni la ficha técnica vigente del fabricante.