Tirotropina (Hormona estimulante de la tiroides)
Thyrotropin (Thyroid Stimulating Hormone)
Thyrotropin alfa (recombinant human TSH)
También conocido como: Thyrogen · Ambinon · Thyreostimulin · Thytropar · Thyroid-stimulating hormone · Thyrotrophic hormone · rhTSH · Recombinant human thyrotropin
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| TSH stimulation test | 75 micrograms (total dose) | IV | Once | — | 🌎 NA |
| TSH stimulation test | 50-100 micrograms (0.05-0.1 mg) | IV | Once | — | 🌎 NA |
| TSH stimulation test | 50-150 μg/dog | IV | single dose | 1 day | 🌍 EU |
- TSH stimulation test: Blood samples taken before and 6 hours after rhTSH administration for determination of total serum thyroxine (T4) concentration.
- TSH stimulation test: Measure serum T4 at 0 hours (pre-sample) and 4 hours post. Product may be frozen for at least 8 weeks with no loss of potency.
- TSH stimulation test: Higher doses offer increased discriminatory power in dogs with comorbidities or those receiving thyroid-suppressing drugs.
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| TSH stimulation test | 25 μg/cat | IV | single dose | 1 day | 🌍 EU |
- TSH stimulation test: The diagnostic value in cats has not been fully assessed.
Aves
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| TSH stimulation test | 1 Unit/kg | IM | Once | — | 🌎 NA |
- TSH stimulation test: Draw pre-dose baseline sample. Collect sample for T4 6 hours after dose.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
La tirotropina (TSH) es una hormona glucoproteica utilizada en medicina veterinaria principalmente como agente diagnóstico en la prueba de estimulación con TSH para diagnosticar el hipotiroidismo primario.
- Uso histórico: Anteriormente disponible como un producto veterinario de origen bovino (Dermathycin®) para el tratamiento de la acantosis nigricans y como terapia de apoyo temporal en el hipotiroidismo.
- Práctica actual: El producto disponible comercialmente se deriva ahora de fuentes humanas mediante tecnología de ADN recombinante (rhTSH). Es altamente purificado y preferido sobre los productos antiguos derivados de animales debido a su mejor disponibilidad y potencia estandarizada.
- Perla clínica: La prueba de estimulación con TSH se considera el estándar de oro para evaluar la reserva tiroidea y confirmar un diagnóstico de hipotiroidismo cuando las concentraciones basales de T4 y de TSH canina endógena son equívocas.
Mecanismo de acción
Thyrotropin binds to TSH receptors on the basolateral membrane of thyroid follicular cells. This binding activates the adenylate cyclase/cAMP pathway, which stimulates multiple steps in thyroid hormone synthesis:
- Increases iodine uptake (trapping) by the thyroid gland.
- Stimulates the iodination of tyrosine residues on thyroglobulin.
- Increases the production and secretion of active thyroid hormones (T3 and T4) into the systemic circulation.
With prolonged use, hyperplasia of thyroid cells may occur, though this is not a concern with single-dose diagnostic use.
Seguridad y advertencias
Contraindicaciones
- Adrenocortical insufficiency (untreated Addison's disease)
- Hyperthyroidism
- Coronary thrombosis
- Hypersensitivity to bovine thyrotropin or human proteins
- Repeated administration is not advisable
- Patients currently receiving levothyroxine therapy
- Use of chemical grade TSH (due to anaphylaxis risk)
Efectos adversos
- Hypersensitivity reactions (especially with repeated injections of human-derived proteins in animals)
- Clinical signs of hyperthyroidism (with chronic administration or high doses)
- Anaphylactic responses (specifically associated with chemical grade/bovine TSH; recombinant forms are generally well tolerated)
Precauciones
Hypersensitivity Warning: Because the commercially available product is derived from human sources, hypersensitivity reactions may occur in patients sensitive to human proteins, particularly with repeated use.
- Pregnancy: FDA Category C. Animal studies have shown an adverse effect on the fetus, but there are no adequate studies in humans.
- Nursing: Unknown if excreted in milk, but unlikely to be clinically significant when used for a one-time diagnostic test.
Interacciones farmacológicas
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
Monitorización
- Serum total T4 concentrations (baseline and 4-6 hours post-administration)
- Clinical signs of hypersensitivity or anaphylaxis during and immediately after administration
- Serum total T4 levels (baseline and post-stimulation, typically 4-6 hours post-injection)
Farmacocinética
Absorción
Exogenously administered TSH apparently exerts maximal increases in circulating T4 approximately 4-8 hours after IM or IV administration.
Metabolismo
Degraded primarily in the kidneys and liver.
Eliminación
Cleared via renal and hepatic pathways.
Sobredosis
Chronic administration at high dosages can produce clinical signs of hyperthyroidism (e.g., weight loss, polyphagia, tachycardia, hyperactivity).
Massive overdoses can cause clinical signs resembling thyroid storm (a life-threatening hypermetabolic state). Treatment is generally supportive and symptomatic; refer to levothyroxine overdose protocols for specific management strategies.
Productos disponibles
Formulaciones
- Lyophilized powder for injection
- Injectable: 1.1 mg vial (yields 0.9 mg/ml after reconstitution with 1.2 ml sterile water)
Etiquetado para humanos
- Recombinant (human) Thyrotropin (Thyroid Stimulating Hormone) Powder for Injection, Lyophilized: 1.1 mg per vial; Thyrogen® (Genzyme); (Rx)
- Thyrogen 1.1 mg powder for injection
Estado regulador
Human approved drug (Thyrogen) used off-label under the cascade.
Human approved drug (Thyrogen) used off-label under the cascade.
Sin datos reguladores para: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Unreconstituted thyrotropin alfa should be stored between 2-8°C (36-46°F). Reconstituted solution can be stored up to 24 hours between 2-8°C (36-46°F), avoiding microbial contamination. It is reportedly stable if kept refrigerated (2-8°C) up to 4 weeks and up to 8 weeks if frozen (-20°C). Protect from light. Visually inspect each vial for particulate matter or discoloration before use; do not use if present.
Información para el cliente
La tirotropina se utiliza como una prueba diagnóstica de una sola vez para evaluar el funcionamiento de la glándula tiroides de su mascota.
- El procedimiento: A su mascota se le extraerá una muestra de sangre basal, recibirá una inyección de la hormona y luego permanecerá en la clínica (o regresará) para una segunda extracción de sangre de 4 a 6 horas después.
- Seguridad: Debido a que es una proteína derivada de humanos, existe un riesgo muy pequeño de reacción alérgica. Informe a su veterinario de inmediato si nota hinchazón facial, urticaria, vómitos o dificultad para respirar después de la prueba.
- Costo: El producto recombinante humano puede ser costoso, lo cual puede influir en el costo total del estudio diagnóstico.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.