Vitamina E / Selenio
Vitamin E / Selenium
Alpha-tocopherol / Sodium selenite
También conocido como: Emulsivit E-300 · Vital E-300 · Equ-SeE · Equ-Se5E · Mu-Se · Bo-Se · L-Se · E-Se · Seletoc · Aquasol E · Nutr-E-Sol · Alpha-tocopherol · Sodium selenite
Revisado por el equipo veterinario de VetSheetActualizado 5 abr 2026Referencia veterinaria basada en la evidencia
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Dosis por especie
🌎 NA — North America🌍 EU — Europe
Perros
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Adjunctive treatment of discoid lupus erythematosus, canine demodicosis or acanthosis nigricans | 200-400 Units PO three times daily | PO | q8h | — | 🌎 NA |
| Adjunctive treatment of cholestatic hepatopathies; necroinflammatory hepatopathies | 10-15 Units/kg per day PO as alpha-tocopherol acetate | PO | q24h | — | 🌎 NA |
| Adjunctive treatment of copper-associated hepatopathy | 400-600 Units PO per day | PO | q24h | — | 🌎 NA |
| Treatment of tocopherol deficiency associated with exocrine pancreatic disease | 100-400 Units PO once daily for one month then every 1-2 weeks as needed | PO | q24h | 1 month, then q1-2 weeks | 🌎 NA |
| Vitamin E/Selenium deficiency (using Seletoc) | Initially, 1 mL per 20 pounds of body weight (minimum 0.25 mL; maximum 5 mL) SC, or IM in divided doses in 2 or more sites. Repeat dose at 3 day intervals until satisfactory results then switch to maintenance dose. Maintenance dose: 1 mL per 40 lbs body weight (minimum 0.25 mL) repeat at 3-7 day intervals (or longer) to maintain. | SC/IM | q3d initially, then q3-7d | — | 🌎 NA |
- Adjunctive treatment of discoid lupus erythematosus, canine demodicosis or acanthosis nigricans: Variable efficacy, but relatively innocuous at these dosages
- Vitamin E/Selenium deficiency (using Seletoc): If no response in 14 days reevaluate.
Gatos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Treatment of tocopherol deficiency associated with exocrine pancreatic disease | 30 Units PO once daily for one month then every 1-2 weeks as needed | PO | q24h | 1 month, then q1-2 weeks | 🌎 NA |
| Adjunctive treatment of hepatic lipidosis | 10 Units/kg once PO once daily | PO | q24h | — | 🌎 NA |
Caballos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Adjunctive treatment of ionophore (monensin) toxicity | 4-12 Units/kg PO once daily | PO | q24h | — | 🌎 NA |
| Adjunctive therapy for EPM | 8000-9000 Units PO per day | PO | q24h | — | 🌎 NA |
| Adjunctive therapy for metabolic syndrome | 10,000 Units PO once daily | PO | q24h | — | 🌎 NA |
| Adjunctive treatment of perinatal asphyxia syndrome (hypoxic ischemic encephalopathy) | Foals: 4,000 Units PO once daily; Mares: 10,000 Units PO once daily | PO | q24h | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using E-Se) | 1 mL/100 lbs. body weight slow IV or deep IM (in 2 or more sites; gluteal or cervical muscles). May be repeated at 5-10 day intervals. | IV/IM | q5-10d | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using E-Se): Give slowly when administering IV.
Ganado
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Mu-Se) | For weanling calves: 1 mL per 200 lbs. body weight IM or SC. For breeding beef cows: 1 mL per 200 lbs. body weight during middle third of pregnancy and 30 days before calving IM or SC. | IM/SC | Variable | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using Bo-Se) | Calves: 2.5-3.75 mL/100 lbs body weight (depending on severity of condition and geographical area) IM or SC. | IM/SC | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Mu-Se): Slaughter withdrawal = 30 days.
- Vitamin E/Selenium deficiency (using Bo-Se): Slaughter withdrawal = 30 days.
Cerdos
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Bo-Se) | Sows and weanling pigs: 1mL/40 lbs. body weight IM or SC (1 mL minimum). | IM/SC | Single dose | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using L-Se) | Baby Pigs: 1 mL SC or IM. | SC/IM | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Bo-Se): Do not use on newborn pigs. Slaughter withdrawal = 14 days.
- Vitamin E/Selenium deficiency (using L-Se): Slaughter withdrawal = 14 days.
Ovejas
| Indicación | Dosis | Vía | Frecuencia | Duración | Región |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Bo-Se) | Lambs (2 weeks of age or older): 1 mL per 40 lbs. body weight IM or SC (1 mL minimum). Ewes: 2.5 mL/100 lbs. body weight IM or SC. | IM/SC | Single dose | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using L-Se) | Lambs: 1 mL SC or IM in newborns and 4 mL SC or IM in lambs 2 weeks of age or older | SC/IM | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Bo-Se): Slaughter withdrawal = 14 days.
- Vitamin E/Selenium deficiency (using L-Se): Slaughter withdrawal = 14 days.
Las dosis son una referencia clínica para profesionales veterinarios autorizados. Confirme siempre con el prospecto actual y cada paciente individual.
Resumen
La vitamina E y el selenio se utilizan frecuentemente juntos debido a sus propiedades antioxidantes sinérgicas, aunque la vitamina E también se usa ampliamente como suplemento independiente.
- Vitamina E (Alpha-tocopherol) es una vitamina liposoluble esencial para proteger las membranas celulares del daño oxidativo. Se utiliza como coadyuvante para diversas afecciones dermatológicas (discoid lupus, demodicosis), hepáticas y neurológicas.
- Selenio es un oligoelemento que actúa como un cofactor crucial para las enzimas antioxidantes. Los productos combinados están indicados principalmente para el tratamiento o la profilaxis de síndromes de deficiencia de selenio-tocoferol (STD), como la enfermedad del músculo blanco en el ganado.
Perla clínica: Si bien la vitamina E tiene un amplio margen de seguridad, el selenio es altamente tóxico en caso de sobredosis. Los productos combinados deben dosificarse meticulosamente según la concentración de selenio y solo deben usarse en especies aprobadas por la FDA.
Mecanismo de acción
Both Vitamin E and Selenium are intricately involved in the cellular metabolism of sulfur and the prevention of oxidative stress.
- Vitamin E acts as a potent biological free radical scavenger. It prevents the oxidation of polyunsaturated fatty acids within cellular and subcellular membranes.
- Selenium is an essential structural component of the enzyme glutathione peroxidase → this enzyme catalyzes the reduction of lipid hydroperoxides to their corresponding alcohols, neutralizing their potential to cause cellular damage.
Together, they protect against red blood cell hemolysis and prevent the destructive action of peroxidase on unsaturated bonds in cell membranes.
Seguridad y advertencias
Contraindicaciones
- Use of combination products in non-FDA approved species
- Use of Bo-Se in newborn pigs
Efectos adversos
- Anaphylactoid reactions
- Transient muscle soreness at injection sites (IM)
- Selenium toxicity (depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness, garlic breath)
Precauciones
Vitamin E/selenium products should only be used in the species for which they are FDA-approved. Because selenium can be extremely toxic, the promiscuous use of these products cannot be condoned. Give slowly when administering intravenously to horses.
Interacciones farmacológicas
Large doses of vitamin E may delay the hematologic response to iron therapy in patients with iron deficiency anemia.
May reduce the absorption of orally administered vitamin E.
Absorption, utilization, and storage may be enhanced by vitamin E.
Vitamin E may increase the effects of warfarin.
Monitorización
- Clinical efficacy
- Blood selenium levels (when using combination products)
- Glutathione peroxidase activity (optional)
Farmacocinética
Absorción
After absorption, vitamin E is transported in the circulatory system via beta-lipoproteins. Absorption of vitamin E may be impaired in patients with severe cholestatic liver disease or in animals with fat malabsorption syndromes.
Distribución
Vitamin E is distributed to all tissues and stored in adipose tissue. It is only marginally transported across the placenta.
Metabolismo
Vitamin E is metabolized in the liver.
Eliminación
Vitamin E is excreted primarily into the bile.
Sobredosis
Selenium is quite toxic in overdose quantities, but has a fairly wide safety margin. Cattle have tolerated chronic doses of 0.6 mg/kg/day with no adverse effects (approximate therapeutic dose is 0.06 mg/kg).
Clinical signs of selenium toxicity include:
- Depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness
- A distinct 'garlic' odor on the breath
- Horses: May become blind, paralyzed, slough their hooves, and lose hair from the tail and mane.
- Dogs: May exhibit anorexia, vomiting, and diarrhea at high dosages.
Large overdoses of vitamin E alone can cause coagulopathies.
Productos disponibles
Formulaciones
- Injection
- Oral powder
- Oral liquid
- Tablets
- Capsules
Veterinario
- Vitamin E Injection: 300 mg/mL (Emulsivit E-300, Vital E-300)
- Vitamin E/Selenium Oral: Equ-SeE, Equ-Se5E
- Vitamin E/Selenium Injection: Mu-Se (5 mg Se/mL), Bo-Se (1 mg Se/mL), L-Se (0.25 mg Se/mL), E-Se (2.5 mg Se/mL), Seletoc (1 mg Se/mL)
Etiquetado para humanos
- Vitamin E Tablets: 100 Units, 200 Units, 400 Units, 500 Units & 800 Units
- Vitamin E Capsules: 100 Units, 200 Units, 400 Units & 1000 Units
- Vitamin E Drops: 15 Units/0.3 mL
- Vitamin E Liquid: 15 Units/30 mL, 798 Units/30 mL
Estado regulador
Sin datos reguladores para: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
Almacenamiento y estabilidad
Vitamin E/Selenium for injection should be stored at temperatures less than 25°C (77°F).
Información para el cliente
- Dosificación estricta: Nunca exceda la dosis prescrita. Aunque la vitamina E es relativamente segura, el selenio puede ser altamente tóxico si se suplementa en exceso.
- Signos de toxicidad: Contacte a su veterinario inmediatamente si nota un olor a "ajo" en el aliento de su mascota, debilidad extrema, tropiezos, vómitos o dificultad para respirar.
- Administración: Si administra líquidos o cápsulas por vía oral, siga las instrucciones de su veterinario con respecto a la alimentación (a menudo se administran con comida para mejorar la absorción de las vitaminas liposolubles).
- Almacenamiento: Mantenga todos los suplementos fuera del alcance de niños y animales para evitar la ingestión accidental.
La referencia de medicamentos de VetSheet está destinada a profesionales veterinarios autorizados como ayuda para la toma de decisiones clínicas, no como sustituto del criterio profesional ni del prospecto actual del fabricante.