アルフェンタニル

動物種別の用量

用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。

投与経路

禁忌

• Patients hypersensitive to opioids

有害事象

• Dose-related respiratory depression
• Bradycardia
• CNS depression
• Dose-related skeletal muscle rigidity
• Asystole (rare)
• Hypercarbia (rare)
• Hypersensitivity reactions (rare)

薬物相互作用

• CYP3A4 Inhibitors (erythromycin, cimetidine, ketoconazole, itraconazole, fluconazole, diltiazem) · May increase the half-life and decrease the clearance of alfentanil leading to prolonged effect and an increased risk of respiratory depression
• Beta-blockers · May produce bradycardia or hypotension if used concurrently with alfentanil
• Other anesthetic agents · May produce bradycardia or hypotension; respiratory or CNS depression may be exacerbated
• Inhaled anaesthetics · Reduces the dose requirements of concurrently administered anaesthetics by at least 50% · major
• Monoamine oxidase inhibitors (MAOIs) · Risk of serotonin toxicity · major

モニタリング

• Anesthetic and/or analgesic efficacy
• Cardiac rate and rhythm
• Respiratory rate and depth
• Pulse oximetry or other methods to measure blood oxygenation

過量投与

### Signs of Toxicity * **Severe IV Overdose:** Circulatory collapse, pulmonary edema, seizures, cardiac arrest, and death. * **Less Severe Overdose:** CNS and respiratory depression, coma, hypotension, muscle flaccidity, and miosis. ### Treatment * **Supportive Care:** Provide cardiovascular and respiratory support (e.g., mechanical ventilation, IV fluids) as necessary. * **Antidote:** Administration of an opiate antagonist such as **naloxone**. Although alfentanil has a relatively rapid half-life, multiple doses of naloxone may be necessary. > **Measurement Precaution:** Because of the drug's extreme potency, the use of a tuberculin syringe to measure dosages less than 1 mL, along with a dosage calculation and measurement double-check system, is strongly recommended.