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アミトラズ

Amitraz

N-methylbis(2,4-xylyliminomethyl)amine

抗寄生虫薬 / ホルムアミジン系topical犬猫小型哺乳類

別名: Mitaban · Taktic · Preventic · Aludex · ProMeris (historical) · Amitrazum

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

250 ppm (one 10.6 mL bottle in 2 gallons of warm water)topical· q14d· 3-6 treatments (or until 30 days past two negative skin scrapings)
10.6 ml — 個体ごとの固定用量（体重換算なし）

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応用量経路頻度期間地域
Generalized demodicosis (Labeled Protocol)250 ppm (one 10.6 mL bottle in 2 gallons of warm water)topicalq14d3-6 treatments (or until 30 days past two negative skin scrapings)🌎 NA
Generalized demodicosis (Extra-label Protocol 1)250 ppm, 500 ppm, or 1000 ppmtopicalq7dUntil 30 days past two negative skin scrapings🌎 NA
Generalized demodicosis (Extra-label Protocol 2)0.125% solution (1 mL of 12.5% Taktic in 100 mL water)topicalq24hUntil 30 days past two negative skin scrapings🌎 NA
Otic demodicosis1 mL of 12.5% Taktic in 8.5 mL mineral oiltopicalq3-7dUntil resolved🌎 NA
Generalized mite infestations (canine demodicosis, sarcoptic acariasis and cheyletiellosis)Diluted as a dip, left on the coattopicalAs directed (typically weekly or bi-weekly depending on specific product label)Until clinical and microscopic resolution🌍 EU
  • Generalized demodicosis (Labeled Protocol): Apply to entire animal and air dry. DO NOT rinse or towel dry.
  • Generalized demodicosis (Extra-label Protocol 1): Step up concentration if lower doses fail. Increased risk of toxicity at higher doses.
  • Generalized demodicosis (Extra-label Protocol 2): Rub onto one-half of the dog's body and alternate sides daily.
  • Otic demodicosis: Discontinue if irritation develops.
  • Generalized mite infestations (canine demodicosis, sarcoptic acariasis and cheyletiellosis): Clipping long-haired coats will improve penetration. Animals should not be bathed or allowed to swim for 48 hours after application.

猫

適応用量経路頻度期間地域
Follicular demodicosis (Demodex cati)0.0125% (125 ppm)topicalq7-14dUntil resolved🌎 NA
Surface demodicosis (Demodex gatoi)0.0125% (125 ppm)topicalq7d12 weeks🌎 NA
  • Follicular demodicosis (Demodex cati): Extra-label. Monitor very closely for side effects. Use E-collar until dry.
  • Surface demodicosis (Demodex gatoi): Extra-label. Monitor very closely for side effects. Use E-collar until dry.

小型哺乳類

適応用量経路頻度期間地域
Mite treatment (Mice, Rats, Gerbils, Hamsters, Guinea pigs, Chinchillas)1.4 mL per litertopicalq14d3-6 treatments🌎 NA
  • Mite treatment (Mice, Rats, Gerbils, Hamsters, Guinea pigs, Chinchillas): Not recommended in young animals or rabbits.

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

診察中ですか？VetSheet の AI が薬剤・用量・投与期間を構造化された診察記録に直接記入します。VetSheet の仕組みを見る

概要

アミトラズはホルムアミジン系の殺ダニ剤および殺虫剤であり、獣医学では主に犬の全身性ニキビダニ症の治療や、ノミ・マダニの駆除に使用されます。猫やウサギには猛毒です。

作用機序

Acts as a monoamine oxidase (MAO) inhibitor in susceptible mites → alters neurotransmitter breakdown → CNS toxicity and death. Additionally, acts as an alpha-2 adrenergic agonist in mammals → inhibits insulin release → transient hyperglycemia and sedation. Also inhibits prostaglandin synthesis.

安全性・警告

禁忌

  • Cats and rabbits (highly toxic, though extra-label protocols exist)
  • Chihuahuas and toy breeds (use with extreme caution)
  • Puppies less than 4 months of age
  • Dogs with deep pyodermas and draining tracts (treat infection first)
  • Brittle diabetic patients
  • Pregnant or nursing animals

有害事象

  • Transient sedation (up to 72 hours)
  • Ataxia
  • Bradycardia
  • Vomiting and diarrhea
  • Hypothermia
  • Transient hyperglycemia
  • Pruritus, erythema, and edema at application site
  • Seizures (rare)

注意事項

​Safety Warning:​ Liquid concentrates are flammable until diluted.

  • Clients must wear rubber gloves when mixing and applying.
  • Wash hands and arms thoroughly after application.
  • Do not stress animals for at least 24 hours post-application.
  • Use ophthalmic protectants (e.g., petrolatum ointment) if treating near the eyes.
  • Dispose of unused diluted solution by flushing down the drain and do not reuse containers.

医薬品相互作用

Corticosteroids

Immunosuppression can worsen demodicosis; concomitant use is contraindicated.

Selegiline

Concurrent use of MAO inhibitors increases risk of toxicity.

Amitriptyline

Concurrent use with tricyclic antidepressants is not recommended.

Clomipramine

Concurrent use with tricyclic antidepressants is not recommended.

Alpha-2 agonist sedatives (e.g., dexmedetomidine, xylazine)Major

Additive or synergistic CNS depression and cardiovascular effects (bradycardia).

Other ectoparasiticidesModerate

Potential for increased toxicity.

監視

  • Resolution of clinical signs (negative skin scrapings)
  • Blood glucose levels (especially in diabetic patients)
  • Heart rate and body temperature
  • Signs of excessive sedation or CNS depression

薬物動態

吸収

Absorbed systemically through the skin, especially if the skin barrier is compromised.

過剰投与

Toxicity can be significant, especially if amitraz-containing collars are ingested.

  • ​Signs:​ Ataxia, severe CNS depression, bradycardia, hypothermia, and marked hyperglycemia.
  • ​Treatment:​ Emesis (if asymptomatic), endoscopic retrieval of ingested collars, activated charcoal, and cathartics.
  • ​Antidotes:​ Yohimbine (0.11-0.2 mg/kg IV) or Atipamezole can effectively reverse the alpha-2 adrenergic mediated signs (sedation, bradycardia, hyperglycemia). Repeated doses may be necessary due to the short half-life of the reversal agents.

製品

製剤

  • Solution for Dilution: 19.9%
  • Solution (emulsifiable concentrate) for Dilution: 12.5%
  • Spot-On Solution: amitraz 150 mg/mL; metaflumizone 150 mg/mL
  • Collar: 9% amitraz

動物用医薬品

  • Mitaban Solution for Dilution 19.9%
  • Taktic EC Solution 12.5%
  • ProMeris for Dogs Spot-On Solution
  • Preventic Collar 9%

規制ステータス

European Union✓ 承認済み処方箋医薬品EMA
🐕 Dogs🐄 Cattle🐑 Sheep pigs

プール期間: cattle meat 28 days · pig meat 7 days · sheep meat 28 days

Classified as POM-V in the UK/EU.

United Kingdom✓ 承認済み処方箋医薬品VMD
🐕 Dogs🐄 Cattle🐑 Sheep pigs

POM-V (Prescription Only Medicine - Veterinarian).

規制データなし: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Liquid concentrates are flammable. Store at room temperature away from open flames. Once diluted with water, the solution must be used immediately and cannot be stored for future use.

飼主向け情報

アミトラズは重度のダニ感染症を治療するための強力な薬です。使用時は必ずゴム手袋を着用し、使用後は手をよく洗ってください。薬浴後、ペットが24〜72時間ほど非常に眠そうにすることがありますが、これは一般的な副作用です。暖かく静かに過ごさせてください。もしペットが目を覚まさない場合や、3日以上眠気が続く場合は、すぐに獣医師に連絡してください。猫やウサギには絶対に近づけないでください。

VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。