カルボマー980
カルボマー980は、眼科用潤滑剤として使用される合成高分子量のポリアクリル酸架橋ポリマーです。ムチン様作用を持ち、三層構造の涙液層のうち水層およびムチン層を代替します。 **臨床のポイント：** カルボマーゲルは、乾性角結膜炎（KCS/ドライアイ）の管理や、全身麻酔・鎮静中（瞬目反射が低下または消失した際）の角膜保護に非常に有効です。
作用機序: **Carbomer 980** is a linear polymer (**polyacrylic acid**) that acts as a **mucinomimetic**. It adheres to the corneal surface and retains moisture → replaces the aqueous and mucin layers of the trilaminar tear film → stabilizes the tear film, reduces tear evaporation, and prolongs tear break-up time (TBUT).
動物種別の用量
- Keratoconjunctivitis sicca (KCS) / Dry eye / Ocular lubrication · 1 drop (or small strip) per affected eye · topical · prn (typically q6h to q12h) · Ongoing · Frequency depends on the severity of the dry eye.
- Corneal protection during general anesthesia · 1 drop (or small strip) per eye · topical · Once after induction, repeat every 1-2 hours if procedure is prolonged · Duration of anesthesia · Prevents exposure keratitis.
- Keratoconjunctivitis sicca (KCS) / Dry eye / Ocular lubrication · 1 drop (or small strip) per affected eye · topical · prn (typically q6h to q12h) · Ongoing · Frequency depends on the severity of the dry eye.
- Corneal protection during general anesthesia · 1 drop (or small strip) per eye · topical · Once after induction, repeat every 1-2 hours if procedure is prolonged · Duration of anesthesia · Prevents exposure keratitis.
- Ocular lubrication / Anesthesia protection · 1 drop per eye · topical · prn · As needed · Useful for exophthalmic species (e.g., rabbits, guinea pigs) during anesthesia.
用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。
投与経路
禁忌
- Hypersensitivity to carbomer or any component of the formulation (e.g., preservatives like cetrimide or benzalkonium chloride)
有害事象
- Transient blurred vision immediately after application
- Mild, temporary ocular irritation or stinging
- Crusting or matting of the eyelashes/eyelids
薬物相互作用
- Other topical ophthalmic medications · Carbomer gel can act as a physical barrier, reducing the absorption of other ophthalmic drops if applied simultaneously or prior to the drops. · moderate
モニタリング
- Schirmer Tear Test (STT) to monitor tear production in KCS patients
- Resolution of clinical signs (conjunctival hyperemia, mucoid discharge, blepharospasm)
- Fluorescein staining to monitor for corneal ulceration
過量投与
Overdosage is not a clinical concern due to the lack of systemic absorption. Excess gel will simply spill over the eyelid margins and can be gently wiped away with a damp tissue.
VetSheet の薬剤リファレンスは、獣医療従事者向けの臨床意思決定支援を目的としており、専門的判断やメーカーの最新添付文書に代わるものではありません。