ピコリン酸クロム
ピコリン酸クロムは、特に猫の糖尿病や肥満の補助治療として使用される微量金属の栄養補助食品です。臨床的な有効性には議論があり、犬の糖尿病には有用ではないとされています。サプリメントには生物学的に活性な3価クロム（Cr III）が使用されています。
作用機序: Chromium is an active component of the **glucose tolerance factor (GTF)**, a complex of molecules including glycine, glutamic acid, cysteine, and nicotinic acid. While its exact role in carbohydrate and nitrogen metabolism is not fully elucidated, it is thought to enhance **insulin receptor** sensitivity and facilitate glucose transport into cells. * **GTF → Insulin Receptor Binding → Enhanced Intracellular Glucose Uptake** * It does *not* lower blood glucose levels in normal, healthy patients.
動物種別の用量
- For use as an oral hypoglycemic agent · Chromium picolinate 200 micrograms (per cat) PO once a day. · PO · q24h
- For adjunctive treatment of feline obesity · Chromium picolinate 20 micrograms/kg PO every other a day · PO · q48h
用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。
投与経路
禁忌
- Renal insufficiency (use with caution)
有害事象
- Cognitive, perceptual, and motor dysfunction (reported in humans receiving the picolinate salt)
薬物相互作用
- Corticosteroids · May increase the urinary excretion of chromium
- H2 Blockers (cimetidine, ranitidine, famotidine) or Proton Pump Inhibitors (omeprazole) · May decrease chromium levels by inhibiting their absorption; clinical significance is unclear
- NSAIDs · May increase the absorption and retention of chromium; clinical significance is unlikely
- Zinc · Theoretically, co-administration of zinc with chromium could decrease the oral absorption of both
モニタリング
- Fasting blood glucose
- Appetite and attitude
- Body condition and weight
- PU/PD resolution
- Serum fructosamine levels
- Glycosylated hemoglobin levels
過量投与
Little information on acute overdoses is available. In humans, there are case reports of women developing renal failure after taking excessive doses of chromium picolinate.
VetSheet の薬剤リファレンスは、獣医療従事者向けの臨床意思決定支援を目的としており、専門的判断やメーカーの最新添付文書に代わるものではありません。