クレマスチン

動物種別の用量

用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。

投与経路

禁忌

• Known hypersensitivity to clemastine

有害事象

• Sedation (dogs)
• Paradoxical hyperactivity (dogs)
• Anticholinergic effects: dry mucous membranes, tachycardia, urinary retention
• Diarrhea (cats)
• Fixed drug reaction (cats - rare)

薬物相互作用

• CNS Depressant Medications (e.g., barbiturates, tranquilizers) · Additive CNS depression may occur.
• Monoamine Oxidase Inhibitors (e.g., furazolidone, amitraz, selegiline) · May intensify the anticholinergic effects of clemastine.
• CNS Depressants (e.g., phenobarbital, gabapentin, opioids) · Additive CNS depression and sedation · moderate
• Anticholinergic drugs · Additive anticholinergic effects (dry mouth, urinary retention) · moderate

モニタリング

• Clinical efficacy (reduction in pruritus, allergic signs)
• Adverse effects (sedation, hyperactivity, anticholinergic signs)

過量投与

There are no specific antidotes for clemastine overdose. * **Management:** Handle significant overdoses using standard gut-emptying protocols (emesis/gastric lavage) when appropriate, followed by supportive therapy. * **Clinical Signs:** Overdose signs are extensions of the drug's side effects, principally **CNS depression** (though CNS stimulation/seizures may occur), severe **anticholinergic effects** (severe drying of mucous membranes, tachycardia, urinary retention, hyperthermia), and possibly hypotension. * **Specific Treatments:** **Physostigmine** may be considered to treat serious CNS anticholinergic effects. **Diazepam** can be employed to treat seizures if necessary.