VetSheet

ダナゾール

Danazol

Synthetic derivative of ethisterone (ethinyl testosterone)

アンドロゲン / 免疫調節薬PO犬猫

別名: Danocrine · Win-17757 · Anargil · Cyclomen · D-Zol · Danalem · Danazant · Danogen · Danokrin · Danol · Ectopal · Gonablok · Kendazol · Ladazol · Ladogal · Lisigon · Mastodanatrol · Norciden · Vabon · Winobanin · Zendol · Zoldan-A

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

5 mg/kg PO three times daily.PO· q8h
— 🐕

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応用量経路頻度期間地域
Adjunctive treatment of immune-mediated hemolytic anemia (non-regenerative forms)5 mg/kg PO three times daily.POq8h—🌎 NA
Adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia5 mg/kg PO 2-3 times per dayPOq8-12h—🌎 NA
Adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia10 mg/kg/day PO. Once anemia improves, corticosteroids may be slowly tapered and eventually DC'd. When remission maintained by danazol alone, may lower to 5 mg/kg/day. Slowly taper after 2-3 months of normal hemograms with frequent monitoring of hemograms.POq24hLong-term🌎 NA
  • Adjunctive treatment of immune-mediated hemolytic anemia (non-regenerative forms): Used to reduce the dose of glucocorticoids needed for long-term therapy.
  • Adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia: Rarely helpful. Costly and has limited effectiveness.
  • Adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia: Initially given in addition to prednis(ol)one.

猫

適応用量経路頻度期間地域
Adjunctive treatment of immune-mediated hemolytic anemia5 mg/kg PO twice dailyPOq12h—🌎 NA

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

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概要

ダナゾールは​合成アンドロゲン​です。獣医学では主に、犬および猫の​免疫介在性溶血性貧血（IMHA）​や​免疫介在性血小板減少症（ITP）​の補助的免疫調節薬として使用されます。効果が予測しにくく発現が遅いため、通常はグルココルチコイドなどの標準治療に抵抗性を示す場合の救済療法として使用されます。

作用機序

Danazol possesses weak androgenic, anabolic, and antiestrogenic properties. Its immunomodulatory effects are achieved through several mechanisms:

  • Fc Receptor Modulation: Reduces the affinity of autoantibodies for the mononuclear phagocytic system Fc receptors → decreases the macrophage-mediated destruction of antibody-coated red blood cells and platelets.
  • Steroid-Binding Globulin Competition: Competes with glucocorticoids for binding sites on ​corticosteroid-binding globulin (CBG)​ → increases the fraction of free, pharmacologically active glucocorticoids in circulation, enhancing their efficacy.
  • Pituitary-Ovarian Axis Suppression: Inhibits the synthesis of sex steroids and binds directly to sex steroid receptors in target tissues.

安全性・警告

禁忌

  • Pregnancy (Teratogenic - FDA Category X)
  • Nursing/breastfeeding
  • Severe cardiac function impairment
  • Severe renal function impairment
  • Severe hepatic function impairment
  • Undiagnosed abnormal vaginal bleeding

有害事象

  • Hepatotoxicity (rare but significant in dogs)
  • Virilization in females
  • Weight gain
  • Lethargy
  • Edema
  • Testicular atrophy
  • Hirsutism
  • Alopecia
  • Vaginitis (reported in humans)

注意事項

Warning: Danazol is highly teratogenic (FDA Category X) and must not be handled by pregnant women or used in pregnant animals.

  • Use with extreme caution in patients with pre-existing hepatic, renal, or cardiac dysfunction.
  • Laboratory Alterations: May alter thyroid panel results (decreased total T4, increased T3 uptake) without causing true hypothyroidism (free T4 and TSH remain normal).
  • ALT (SGPT) and AST (SGOT) may increase early in therapy but typically decrease towards baseline later in therapy or after discontinuation.

医薬品相互作用

Cyclosporine

May significantly increase cyclosporine levels

Insulin

By affecting carbohydrate metabolism, danazol may affect insulin requirements (doses may need to be increased) in diabetic patients

Warfarin

Concomitant use may enhance the anticoagulant effect as danazol may decrease the synthesis of procoagulant factors in the liver

監視

  • Efficacy (CBC, platelets, reticulocyte count)
  • Hepatic function (baseline and at regular intervals while on therapy)

薬物動態

吸収

Absorbed from the GI tract, but appears to be a rate-limited process (increasing the dosage does not yield a corresponding proportional increase in serum levels).

分布

Distribution information is practically nonexistent; the drug apparently crosses the placenta.

代謝

Believed to be principally metabolized in the liver.

消失

Limited veterinary data available.

過剰投与

No specific information was located regarding acute toxicity in animals. Significant overdoses should initially be handled by contacting an animal poison control center and initiating gut emptying protocols (emesis or gastric lavage, followed by activated charcoal) when applicable.

製品

製剤

  • Capsules

ヒト用医薬品

  • Danazol Capsules: 50 mg, 100 mg, & 200 mg

規制ステータス

規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Danazol capsules should be stored in well-closed containers at room temperature.

飼主向け情報

これは免疫抑制薬です。​効果の発現が遅い​：効果が現れるまでに2〜3ヶ月かかる場合があります。​肝機能の監視​：黄疸（白目や歯茎の黄色化）や食欲不振に注意してください。​妊婦の取り扱い注意​：催奇形性のリスクがあるため、妊娠中の女性は取り扱わないでください。

VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。