デソキシコルトン
コルチコステロイド - 鉱質コルチコイド
原発性副腎皮質機能低下症（アジソン病）の犬および猫における鉱質コルチコイド欠乏に対する長時間作用型の補充療法。治療開始前にアジソン病の確定診断が不可欠である。
作用機序: Acts as a **mineralocorticoid** replacement. It binds to mineralocorticoid receptors in the distal renal tubules → increases sodium reabsorption and promotes potassium excretion → restores electrolyte balance and maintains extracellular fluid volume and blood pressure.
動物種別の用量
Cats
- Primary hypoadrenocorticism (Addison's disease) · Initial dose 2.2 mg/kg · SC · long-acting · Long-term replacement · Experience is limited but higher doses seem to be needed.
Dogs
- Primary hypoadrenocorticism (Addison's disease) · Initial dose 1.5-2.2 mg/kg (final dose can be between 1.0 and 2.7 mg/kg) · SC · long-acting (interval not specified in text) · Long-term replacement · Many authorities start at the lower dose of 1.5 mg/kg SC, particularly in larger dogs.
用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。
投与経路
SC
禁忌
- None strictly listed, but use with caution in congestive heart disease, severe renal disease, primary hepatic failure, or oedema
有害事象
- Pain on injection (rarely repeated in the same animal)
- Polyuria
- Polydipsia
- Hypokalaemia (with overdose)
- Vomiting
- Anorexia
- Muzzle swelling
- Anaphylaxis
薬物相互作用
- Spironolactone · Aldosterone antagonist; counteracts the effects of desoxycortone · major
- Furosemide · May excessively reduce potassium levels · moderate
- Thiazides · May excessively reduce potassium levels · moderate
モニタリング
- Serum sodium and potassium levels
- Hydration status
- Renal function parameters (BUN, Creatinine)
- Clinical signs of Addison's relapse or overdosage (PU/PD)
過量投与
Overdoses may cause **polyuria** and **hypokalaemia**. Monitor electrolytes closely if overdose is suspected.
VetSheet の薬剤リファレンスは、獣医療従事者向けの臨床意思決定支援を目的としており、専門的判断やメーカーの最新添付文書に代わるものではありません。