ジノプロストトロメタミン
Dinoprost Tromethamine
Prostaglandin F2alpha tromethamine
別名: Lutalyse · In-Synch · Amtech Prostamate · idinoprostum trometamoli · PGF(2alpha) THAM · prostaglandin F(2alpha) trometamol · U-14583E
VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
動物種別用量
🌎 NA — North America🌍 EU — Europe
犬
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Treatment of pyometra (open cervix, non-critically ill, ≤6 years old) | Day 1: 0.1 mg/kg SC once; Day 2: 0.2 mg/kg SC once; Days 3-7: 0.25 mg/kg SC once daily | SC | once daily (escalating dose) | 7 days | 🌎 NA |
| Abortifacient (After day 25 or 30) | maximum dosage of 80-100 micrograms/kg SC twice a day | SC | q12h | 6 days or longer | 🌎 NA |
| Adjunctive therapy for termination of mid-term pregnancy | 0.1 mg/kg SC three times daily for 3 days and then 0.2 mg/kg SC three times daily to effect | SC | q8h | to effect | 🌎 NA |
- Treatment of pyometra (open cervix, non-critically ill, ≤6 years old): Use concurrent antibiotics for 14 days after completion. Reevaluate at 7 and 14 days.
- Abortifacient (After day 25 or 30): Start with half the dose for the first day. Monitor side effects carefully.
- Adjunctive therapy for termination of mid-term pregnancy: Given concurrently with 1-3 micrograms/kg misoprostol intravaginally once daily.
猫
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Treatment of pyometra | Initially 0.1 mg/kg SC, then 0.25 mg/kg SC once a day for 5 days | SC | once daily | 6 days total | 🌎 NA |
| Abortifacient | 2 mg (total dose) per cat IM once a day beginning at day 33 | IM | once daily | Not specified | 🌎 NA |
- Treatment of pyometra: Give bactericidal antibiotics concurrently. Not recommended in animals >8 yrs old.
- Abortifacient: Side effects include prostration, vomiting and diarrhea.
馬
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Difficult to breed mares / Controlling time of estrus | 1 mg per 45 kg body weight IM | IM | once | once | 🌎 NA |
| Luteolysis and to stimulate uterine contractions | 10 mg (total dose) IM once | IM | once | once | 🌎 NA |
| Abortifacient (Prior to 12th day of pregnancy) | 5 mg IM | IM | once | once | 🌎 NA |
| Abortifacient (After 4th month of pregnancy) | 1 mg per 45 kg body weight (1 mg per 100 pounds) daily until abortion takes place | IM | once daily | until abortion | 🌎 NA |
| Abortifacient (From day 80-300) | 2.5 mg q12h | IM | q12h | approx 4 injections on average | 🌎 NA |
| Estrus synchronization (Two injection method) | 5 mg dinoprost IM on day 1 and again on day 16 | IM | day 1 and day 16 | 16 days | 🌎 NA |
牛
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Estrus synchronization | 25 mg IM either once or twice at a 10-12 day interval | IM | once or twice | 10-12 day interval | 🌎 NA |
| Unobserved (silent) estrus | 25 mg IM | IM | once | once | 🌎 NA |
| Pyometra | 25 mg IM twice, 8 hours apart | IM | twice, 8 hours apart | 1 day | 🌎 NA |
| Abortifacient (5-150 days of gestation) | 25-30 mg IM | IM | once | once | 🌎 NA |
| Abortifacient (After 150 days of gestation) | 25 mg dexamethasone with 25 mg dinoprost | IM | once | once | 🌎 NA |
| Induce parturition | 25-30 mg IM | IM | once | once | 🌎 NA |
- Pyometra: Alternatively, 25 mg IM once (McCormack 1986).
- Abortifacient (5-150 days of gestation): Alternatively, 25 mg IM during first 100 days.
- Induce parturition: Delivery will occur in about 72 hours.
豚
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Estrus synchronization (grouping) | 15 mg dinoprost IM, followed in 12 hours by 10 mg IM | IM | twice, 12 hours apart | 1 day | 🌎 NA |
| Abortifacient | 5-10 mg IM | IM | once | once | 🌎 NA |
| Induce parturition | 10-25 mg IM from 2-6 days before expected parturition | IM | once | once | 🌎 NA |
- Estrus synchronization (grouping): At 15-55 days of gestation.
- Abortifacient: Abortion occurs in 24-48 hours.
- Induce parturition: Farrowing usually occurs 24-36 hours later.
羊
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Estrus synchronization | 8 mg IM on day 5 of estrous cycle and repeat in 11 days | IM | twice, 11 days apart | 11 days | 🌎 NA |
| Abortifacient (first two months of pregnancy) | 10-15 mg IM | IM | once | once | 🌎 NA |
- Abortifacient (first two months of pregnancy): Abortion takes place within 72 hours.
ヤギ
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Estrus synchronization | 8 mg IM on day 4 of estrous cycle and repeat in 11 days | IM | twice, 11 days apart | 11 days | 🌎 NA |
| Pseudopregnancy (hydrometra/mucometra) | 5 mg IM once | IM | once | once | 🌎 NA |
| Abortifacient | 5-10 mg IM throughout entire pregnancy | IM | once | once | 🌎 NA |
| Induce parturition | 2.5-20 mg on days 144-149 | IM | once | once | 🌎 NA |
- Abortifacient: Abortion takes place in 4-5 days.
- Induce parturition: Higher dosage (20 mg) yields more predictable interval to delivery.
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
概要
ジノプロストトロメタミンは、天然に存在するプロスタグランジンF2α（PGF2α）のトロメタミン塩であり、複数の動物種の獣医繁殖医学で広く使用されています。
- 大動物：主に牛、馬、豚、小型反芻動物における発情同期化、鈍性発情の治療、子宮蓄膿症の治療、および堕胎薬や分娩誘発薬としての黄体退行薬として使用されます。
- 小動物：犬や猫における堕胎薬として、また開放鎖骨型子宮蓄膿症の補助的内科療法として適応外使用されます。
臨床のポイント：ジノプロストは犬において治療域が非常に狭いです。LD50は推奨治療用量のわずか約5倍であるため、正確な投与と慎重なモニタリングが不可欠です。子宮蓄膿症の新しいプロトコルでは、安全性の観点からアグレプリストンとクロプロステノールまたはミソプロストールの併用が好まれることが多くなっています。
作用機序
Dinoprost acts directly as a prostaglandin F2alpha (PGF2α) analog.
- Luteolysis: Binds to specific PGF2α receptors on the corpus luteum → inhibits steroidogenesis → induces structural and functional regression of the corpus luteum (luteolysis) → rapid decline in serum progesterone levels.
- Myometrial Contraction: Directly stimulates myometrial smooth muscle activity → increases intracellular calcium → induces strong uterine contractions.
- Cervical Relaxation: Promotes relaxation and dilation of the cervix, facilitating the expulsion of uterine contents (fetus or purulent material in pyometra).
安全性・警告
禁忌
- Pregnancy (unless abortion or induced parturition is desired)
- Intravenous (IV) administration
- Animals with bronchoconstrictive respiratory disease (e.g., asthma, 'heaves' in horses)
- Mares with acute or subacute disorders of the vascular system, GI tract, respiratory system, or reproductive tract
- Camelids (associated with acute toxicity and death)
- Relative contraindication: Closed-cervix pyometra
- Extreme caution in elderly (>8 years old) or debilitated animals, or those with severe cardiopulmonary, renal, or hepatic disease
有害事象
- Dogs/Cats: Abdominal pain, emesis, defecation, urination, pupillary dilation followed by constriction, tachycardias, restlessness, anxiety, fever, hypersalivation, dyspnea, panting. Fatalities are possible (especially in dogs). Cats may exhibit intense grooming and vocalization.
- Cattle: Infection at injection site, salivation, hyperthermia (especially at higher doses).
- Swine: Erythema, pruritus, urination, defecation, slight ataxia, hyperpnea, dyspnea, nesting behavior, abdominal muscle spasms, tail movements, increased vocalization, salivation.
- Horses: Transient decreased body temperature, sweating. Less frequently: increased respiratory and heart rates, ataxia, abdominal pain, lying down.
注意事項
HUMAN SAFETY WARNING: Pregnant women, asthmatics, and women of childbearing age should handle this product with extreme caution. Accidental skin exposure should be washed off immediately with soap and water.
VETERINARY PRECAUTIONS:
- Do NOT administer intravenously (IV).
- Use with extreme caution in dogs and cats over 8 years of age or those with significant concurrent illness.
- Monitor small animals closely for severe cardiorespiratory effects after administration.
- Closed-cervix pyometra is considered a relative contraindication due to the risk of uterine rupture from induced contractions.
医薬品相互作用
Activity may be enhanced by dinoprost.
Reduced effect of dinoprost would be expected with concomitant administration.
監視
- Cardiorespiratory effects (especially in dogs and cats, particularly after higher dosages)
- Adverse effects (vomiting, diarrhea, hyperthermia, distress)
- Efficacy of treatment (e.g., ultrasound for pyometra resolution or pregnancy termination, observation for estrus)
薬物動態
半減期
吸収
Distributes very rapidly to tissues after injection.
分布
Rapidly distributed to tissues.
過剰投与
Dogs are highly sensitive to the toxic effects of dinoprost. The LD50 in the bitch is reported to be 5.13 mg/kg SC, which is only about 5 times greater than the recommended dose used by some clinicians.
In large animals (cattle, swine, horses), overdose quantities (e.g., 5-10X recommended doses) result in exaggerated adverse effects such as hyperthermia, vomiting, and severe abdominal cramping.
Treatment: If clinical signs are severe in any species, immediate supportive and symptomatic therapy is recommended.
製品
製剤
- Injection: 5 mg/mL (as dinoprost) in 10 mL and 30 mL vials
動物用医薬品
- Dinoprost Tromethamine for injection, equivalent to 5 mg/mL of dinoprost in 10 mL and 30 mL vials (Lutalyse Sterile Solution, Amtech Prostamate, In-Synch, Prostamate)
規制ステータス
規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
保管・安定性
Store at room temperature (15-30°C) in airtight containers. Dinoprost is considered to be relatively insensitive to heat, light, and alkalis.
飼主向け情報
人間の安全に関する重大な警告：妊婦、喘息患者、または気管支疾患のある方は、この製品を極めて慎重に取り扱う必要があります。誤って皮膚に触れた場合は、直ちに石鹸と水で洗い流してください。
- この薬は、生殖器系の状態（子宮感染症/子宮蓄膿症など）の管理や、望まない妊娠の中絶に使用されます。
- 犬や猫では、注射後すぐに（通常5〜15分以内）副作用が見られることが予想されます。これらには、パンティング（あえぎ呼吸）、よだれ、嘔吐、下痢、排尿、落ち着きのなさなどが含まれます。
- これらの副作用を見るのは辛いかもしれませんが、通常20〜30分で治まります。この間、ペットを快適で掃除しやすい場所に置いてください。
- ペットが深刻な呼吸困難や極度の無気力に陥った場合、または副作用が続く場合は、直ちに獣医師に連絡してください。
VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。