エプシプランテル
エプシプランテルは、犬および猫に用いられる経口の**条虫駆除薬**です。 - **適応症**: 犬の瓜実条虫（*Dipylidium caninum*）および豆状条虫（*Taenia pisiformis*）、猫の瓜実条虫および猫条虫（*Taenia taeniaeformis*）の駆除。 - **臨床的特徴**: プラジクアンテルとは異なり、消化管からの吸収が非常に悪いため、全身性の副作用が少なく安全域が広いのが特徴です。
作用機序: While the exact mechanism of action against cestodes is not fully elucidated, epsiprantel acts directly on the tapeworm: - **Calcium Dysregulation** → Induces severe tetany (muscle spasms) in the parasite. - **Attachment Disruption** → Causes the tapeworm to lose its grip on the host's intestinal mucosa. - **Integument Alteration** → Damages the worm's outer protective layer, rendering it highly vulnerable to digestion by the host animal's gastrointestinal enzymes.
動物種別の用量
- Cestode infection (Dipylidium caninum, Taenia taeniaeformis) · 2.75 mg/kg · PO · once · Single dose · Cats up to 10 lb should receive one 12.5 mg tablet; cats 11-20 lb should receive one 25 mg tablet
- Cestode infection (Dipylidium caninum, Taenia pisiformis) · 5.5 mg/kg (2.5 mg/lb) · PO · once · Single dose · Round up to the next larger tablet size
用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。
投与経路
禁忌
- Puppies less than 7 weeks of age
- Kittens less than 7 weeks of age
有害事象
- Vomiting (rare)
- Diarrhea (rare)
薬物相互作用
- Prokinetic agents · Theoretically may reduce the drug's efficacy by decreasing gastrointestinal transit time
- Fast-acting laxatives · Theoretically may reduce the drug's efficacy
モニタリング
- Clinical efficacy (resolution of tapeworm infection)
過量投与
Acute toxicity resulting from an inadvertent overdose is highly unlikely due to poor systemic absorption. - **Cats**: Doses as high as 36X the recommended dose resulted in vomiting in some of the kittens tested. - **Dogs**: Single doses of 36X those recommended in dogs caused no adverse effects.
VetSheet の薬剤リファレンスは、獣医療従事者向けの臨床意思決定支援を目的としており、専門的判断やメーカーの最新添付文書に代わるものではありません。