フルララネル
Fluralaner
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide
別名: Bravecto Plus · Fluralanerum
VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス
監査済み v13 用量エビデンス
構造化された用量計算エビデンスOtodectes cynotis (extra-label)
認証済み獣医師の確認が必要
- once
NA
必ず考慮する臨床コンテキスト (1)
- Do not store fluralaner chewable tablets above 30°C (86°F) or topical solutions above 25°C (77°F). Store in the original packaging to protect from moisture. The topical solution is highly flammable. Keep away from heat, sparks, open flame, or other sources of ignition.
Sarcoptes scabiei var canis infestation (extra-label)
認証済み獣医師の確認が必要
- once
NA
必ず考慮する臨床コンテキスト (1)
- Do not store fluralaner chewable tablets above 30°C (86°F) or topical solutions above 25°C (77°F). Store in the original packaging to protect from moisture. The topical solution is highly flammable. Keep away from heat, sparks, open flame, or other sources of ignition.
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
概要
フルララネルは、主に犬および猫のノミやマダニの駆除・予防に使用される全身性のイソキサゾリン系外部寄生虫駆除薬です。作用持続時間が長く、通常1回の投与で最大12週間効果が持続します。
臨床のヒント: 犬用の経口チュアブル錠は、胃腸からの吸収を最大化するために必ず食事と一緒に投与してください。てんかんや神経疾患の既往歴がある動物には慎重に使用してください。
作用機序
Fluralaner acts as an ectoparasiticide by antagonizing ligand-gated chloride channels.
It specifically targets channels gated by the neurotransmitter gamma-aminobutyric acid (GABA) and glutamate (GluCl) → blocks pre- and post-synaptic transfer of chloride ions across cell membranes → results in uncontrolled central nervous system activity and death of insects and acarines.
安全性・警告
禁忌
- Known hypersensitivity to fluralaner or any excipients
- Use with caution in dogs or cats with pre-existing epilepsy or seizure disorders
- Puppies less than 8 weeks of age or weighing less than 2 kg
- Kittens less than 11 weeks of age or weighing less than 1.2 kg
有害事象
- Vomiting
- Diarrhea
- Lethargy
- Decreased appetite
- Application site reactions (erythema, pruritus, alopecia for topical forms)
- Rare neurological signs (muscle tremors, ataxia, seizures)
- Neurologic signs (tremors, ataxia, seizures - rare)
- Application site reactions (erythema, pruritus - topical forms)
注意事項
Neurologic Warning: Isoxazolines have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures, even in animals without a prior history.
Ensure accurate dosing based on body weight. Do not break or divide chewable tablets.
医薬品相互作用
Fluralaner is highly bound to plasma proteins and might theoretically compete with other highly bound drugs, though clinical significance is generally low.
Fluralaner is highly protein-bound and may theoretically compete with other highly bound drugs, though clinical significance is generally considered low.
監視
- Efficacy of parasite control
- Signs of gastrointestinal upset
- Neurological status (especially in animals with a history of seizures)
- Adverse neurologic signs (tremors, ataxia, seizures)
薬物動態
半減期
吸収
Readily absorbed following oral administration in dogs when given with food. Topical formulations are absorbed systemically through the skin.
分布
Highly bound to plasma proteins. Distributes widely to tissues, particularly fat, which acts as a depot.
代謝
Undergoes minimal hepatic metabolism.
消失
Eliminated primarily unchanged in the feces via biliary excretion, with a very minor portion excreted in urine.
過剰投与
Fluralaner is generally well tolerated. In safety studies, oral administration of up to 5 times the maximum recommended dose in dogs produced no severe adverse effects. Overdoses may increase the risk of gastrointestinal upset or transient neurological signs. Treatment is symptomatic and supportive.
製品
製剤
- Oral chewable tablets (dogs)
- Topical spot-on solution (dogs and cats)
- Topical spot-on solution with moxidectin (cats)
- Topical spot-on solution combined with moxidectin (cats)
動物用医薬品
- Bravecto chewable tablets for dogs (112.5 mg, 250 mg, 500 mg, 1000 mg, 1400 mg)
- Bravecto spot-on solution for dogs and cats (280 mg/ml)
- Bravecto Plus spot-on solution for cats (280 mg/ml fluralaner + 14 mg/ml moxidectin)
- Bravecto spot-on for dogs and cats (280 mg/ml)
- Bravecto Plus spot-on for cats (280 mg/ml fluralaner + 14 mg/ml moxidectin)
規制ステータス
FDA approved for flea and tick control.
POM-V
POM-V
規制データなし: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
保管・安定性
Store at room temperature (below 30°C). Keep in original packaging to protect from moisture and light.
飼主向け情報
薬が適切に吸収されるよう、チュアブル錠は食事の際または食後すぐに愛犬に与えてください。この薬は最大12週間にわたりノミとマダニを予防します。投与後、軽度の胃腸障害（嘔吐や下痢）がないかペットを観察してください。筋肉の震え、運動失調、または発作が見られた場合は、直ちに獣医師に連絡してください。
VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。