グラピプラント

動物種別の用量

用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。

投与経路

禁忌

• Hypersensitivity to grapiprant
• Concurrent use with other NSAIDs or corticosteroids
• Breeding, pregnant, or lactating dogs
• Dogs under 9 months of age or weighing less than 3.6 kg
• Dogs under 9 months of age
• Dogs weighing less than 3.6 kg
• Cats (not authorized for use)
• Known hypersensitivity to grapiprant

有害事象

• Vomiting
• Diarrhea
• Anorexia
• Lethargy
• Decreased serum albumin
• Soft-formed faeces
• Diarrhoea
• Inappetence
• Mild decreases in serum albumin and total protein
• Haematemesis (very rare)
• Haemorrhagic diarrhoea (very rare)

薬物相互作用

• Other NSAIDs · Increased risk of gastrointestinal toxicity · major
• Corticosteroids · Increased risk of gastrointestinal ulceration · major
• Highly protein-bound drugs · Potential competition for protein binding sites · moderate
• Other NSAIDs (e.g., meloxicam, carprofen) · Increased risk of gastrointestinal toxicity and adverse effects. Concurrent use should be avoided. · major
• Corticosteroids (e.g., prednisolone, dexamethasone) · Increased risk of gastrointestinal ulceration and adverse effects. Concurrent use should be avoided. · major

モニタリング

• Clinical response (pain scoring)
• Fecal consistency
• Appetite
• Baseline and periodic CBC, serum biochemistry (especially albumin, BUN, creatinine, liver enzymes)
• Clinical response to pain management
• Signs of gastrointestinal upset or ulceration (vomiting, diarrhoea, melaena)
• Serum albumin and total protein levels
• Baseline and periodic renal and hepatic panels, especially in older or compromised patients

過量投与

Overdoses up to 15x the recommended dose for 9 months resulted in mild, transient GI signs (vomiting, soft feces) and mild decreases in total protein and albumin. No specific antidote exists; treat symptomatically with GI protectants and supportive care.