ヘモグロビングルタマー200（ウシ由来）
Hemoglobin glutamer-200 (bovine)
Polymerized bovine hemoglobin
別名: Oxyglobin · HBOC-301 · HG-200 · Hemoglobin glutamer-200 · Hb200
VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
動物種別用量
🌎 NA — North America🌍 EU — Europe
犬
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Labeled indications (anemia) | 10-30 mL/kg | IV | One-time dose at a rate of up to 10 mL/kg/hr | — | 🌎 NA |
| Resuscitation of trauma patients in shock with or without hemorrhage | 3-5 mL/kg | IV | Once | — | 🌎 NA |
| To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction | 7-10 mL/kg or 30 mL/kg | IV | q12h (for 7-10 mL/kg dose) | 48-72 hours (for 30 mL/kg dose) | 🌎 NA |
| As an option to provide oxygen carrying capacity in the trauma patient | 10-15 mL/kg | IV | Given over several hours | — | 🌎 NA |
| As a vasopressor once there is adequate intravascular volume in trauma patients | 3-5 mL/kg | IV | Once | — | 🌎 NA |
- Labeled indications (anemia): Do not administer with other fluids or drugs via the same infusion set.
- Resuscitation of trauma patients in shock with or without hemorrhage: With concurrent crystalloid at 1/2 to 2 times maintenance.
- To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction: 7-10 mL/kg maintains Hb >3.5 g/dL; 30 mL/kg provides support for 48-72h.
- As an option to provide oxygen carrying capacity in the trauma patient: Care must be taken not to cause fluid overload.
猫
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| As an option to provide oxygen carrying capacity in the trauma patient | 2.5-10 mL/kg | IV | Given over several hours | — | 🌎 NA |
- As an option to provide oxygen carrying capacity in the trauma patient: Care must be taken not to cause fluid overload especially in cats.
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
概要
ヘモグロビングルタマー200（ウシ由来） は、獣医療において主に酸素運搬輸液および強力なコロイドとして使用される、半合成の重合ウシヘモグロビン製品です。
- 主な適応症：全血や濃厚赤血球が入手できない場合、または交差適合試験で適切なドナーが見つからない場合の貧血（溶血、失血、または無効造血による）の治療。
- 臨床的ポイント：再生性貧血や緊急のトラウマ（外傷）状況で特に有用です。ストロマフリーであり赤血球膜を持たないため、投与前の血液型判定や交差適合試験は不要です。
- 適応外使用：猫や、新生仔同種免疫性溶血性貧血の仔馬にも使用されていますが、強力なコロイド特性があるため極めて慎重な投与が求められます。
作用機序
HG-200 functions both as an oxygen carrier and a potent colloid expander:
- Oxygen Delivery: Releases oxygen to tissues similarly to endogenous hemoglobin. It shifts the oxygen dissociation curve to the right, facilitating easier oxygen offloading to hypoxic tissues.
- Microvascular Perfusion: Due to its small molecular size compared to intact RBCs, it can bypass severe arterial constrictions to oxygenate ischemic cells.
- Colloidal Effect: Acts as a potent colloid (similar to dextran 70 or hetastarch), expanding intravascular volume by increasing oncotic pressure.
- Vascular Tone: Causes significant vasoconstriction, which can increase blood pressure but may decrease cardiac output in hypovolemic states.
安全性・警告
禁忌
- Advanced cardiac disease (e.g., congestive heart failure)
- Severely impaired cardiac function
- Renal impairment with oliguria or anuria
有害事象
- Discolored mucous membranes, sclera, skin (yellow, red, brown)
- Discolored urine (orange, red, brown)
- Increased central venous pressure (CVP)
- Ventricular arrhythmias (AV block, tachycardia, VPCs)
- Vomiting, diarrhea, anorexia
- Tachypnea, dyspnea, harsh lung sounds
- Pulmonary edema and pleural effusion (due to volume overload)
- Fever
- Peripheral edema
- Hemoglobinuria
注意事項
HG-200 is a potent colloid and can cause severe vasoconstriction. Extreme care must be taken to avoid volume overload, which can lead to increased hydrostatic pressure, pulmonary edema, and pleural effusion (particularly important in cats). The volume required for fluid resuscitation is approximately 1/3 that of hetastarch. May cause immunologic reactions (IgG antibodies), though anaphylaxis is rare. Laboratory Interference: HG-200 severely impacts colorimetric laboratory tests, optical coagulation assays, and urine dipsticks. PCV and RBC counts are inaccurate measures of anemia for 24 hours post-administration due to dilutional effects.
監視
- Hemoglobin levels
- Clinical signs of adequate tissue oxygenation
- Central venous pressure (CVP) and signs of circulatory overload
- Respiratory rate and effort (watch for pulmonary edema)
- Heart rate and rhythm (watch for arrhythmias)
薬物動態
半減期
吸収
Administered intravenously. Peak plasma hemoglobin concentrations increase dose-dependently (e.g., ~2.5 g/dL at 15 mL/kg).
分布
Remains primarily in the intravascular space where it acts as a potent colloid. Duration of effect continues for at least 24 hours.
代謝
Metabolized and eliminated by the reticuloendothelial system, similar to endogenous hemoglobin.
消失
Small amounts of unstabilized hemoglobin (<5%) may be excreted through the kidneys, causing red discoloration of the urine. Detectable in plasma for 5-7 days.
過剰投与
Clinical signs of overdosage (1 to 3 times the recommended dose) include yellow-orange discoloration of skin, mucous membranes, and sclera; red-dark-green-black feces; brown-black urine; decreased appetite/thirst; vomiting; diarrhea; and decreased skin elasticity. Overdosage or excessively rapid administration (>10 mL/kg/hr) may result in severe circulatory overload (pulmonary edema, pleural effusion).
製品
製剤
- Intravenous infusion bags (60 mL, 125 mL)
動物用医薬品
- Hemoglobin Glutamer-200 (bovine) 13 g/dL in 60 mL and 125 mL ready-to-use infusion bags (Oxyglobin)
規制ステータス
規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
保管・安定性
Store at room temperature or refrigerated (2°-30°C) for up to 3 years. Do not freeze. Must remain in its foil overwrap during storage to protect the hemoglobin from converting to methemoglobin. Once removed from the overwrap, it should be used within 24 hours.
飼主向け情報
重要なお知らせ：この薬は、本物の血液が入手できない、または適合しない生命を脅かす緊急事態に使用される一時的な「人工血液」です。
- 変色は正常です：ペットの歯茎、皮膚、目、尿が黄色、オレンジ、赤、または茶色になることがあります。これは薬の無害な影響であり、数日で消えます。
- 呼吸の問題に注意：この輸液は血管内に水分を引き込むため、肺に水が溜まる可能性があります。ペットの呼吸が速い、咳をする、または息苦しそうにしている場合は、すぐに獣医師に連絡してください。
- 費用とリスク：これは集中治療用の薬であり、高額な費用と潜在的なリスクを伴います。使用前に獣医師がリスクとメリットのバランスについて説明します。
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