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Hydrocortisone

局所用コルチコステロイド（低力価）topicalPOIVIMTopical犬猫

別名: Corticalm · Sulfodene HC · Zymox · Dermacool HC · Cortisoothe · Efcortesol · Solu-cortef · Cortisol

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

Initially used sparingly 1-4 times per day and then frequency is tapered when control is achieved. Shampoos: once a day to once a week (leave on 10 mins).topical· q6-24h· < 2 months

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応用量経路頻度期間地域
Focal or multifocal pruritic/inflammatory lesionsInitially used sparingly 1-4 times per day and then frequency is tapered when control is achieved. Shampoos: once a day to once a week (leave on 10 mins).topicalq6-24h< 2 months🌎 NA

猫

適応用量経路頻度期間地域
Focal or multifocal pruritic/inflammatory lesionsInitially used sparingly 1-4 times per day and then frequency is tapered when control is achieved. Shampoos: once a day to once a week (leave on 10 mins).topicalq6-24h< 2 months🌎 NA

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

診察中ですか？VetSheet の AI が薬剤・用量・投与期間を構造化された診察記録に直接記入します。VetSheet の仕組みを見る

概要

低力価の局所用コルチコステロイドと見なされており、局所的なそう痒性および/または炎症性疾患の補助治療に有用です。高力価のステロイドと比較してリスクが低いため、特に広範囲や小型の患者に対する最初の選択肢として適しています。

作用機序

Corticosteroids are non-specific anti-inflammatory agents. They act by inducing ​phospholipase A2 inhibitory proteins (lipocortins)​ in cells → reducing the formation, activity, and release of endogenous inflammatory mediators (e.g., histamine, prostaglandins, kinins).

They also reduce DNA synthesis via an anti-mitotic effect on epidermal cells and inhibit the migration of leukocytes and macrophages to the area, reducing erythema, pruritus, and edema.

安全性・警告

禁忌

  • Tuberculosis of the skin
  • Pregnancy (relative contraindication)
  • Pregnant animals
  • Renal disease (systemic use generally contraindicated)
  • Diabetes mellitus (systemic use generally contraindicated)

有害事象

  • Skin atrophy (with long-term use)
  • Skin fragility
  • Superficial follicular cysts (milia)
  • Comedones
  • HPA axis suppression (rare, but possible with long-term use)
  • Weight loss (catabolic effect)
  • Cutaneous atrophy
  • Iatrogenic hyperadrenocorticism (PU/PD, elevated liver enzymes)
  • Vomiting
  • Diarrhoea
  • Gastrointestinal ulceration
  • Increased urine glucose levels
  • Decreased serum T3 and T4 values
  • Hypothalamic-pituitary axis suppression (with prolonged use)
  • Adrenal atrophy
  • Impaired wound healing
  • Delayed recovery from infections
  • Brain damage (if hyponatraemia is corrected excessively rapidly)

注意事項

Important: Clients should wash hands after application or wear gloves. Avoid contact with eyes. Do not allow the animal to lick or chew at affected sites for at least 20-30 minutes after application.

Residual activity may affect intradermal or allergy serum tests; stop use 2 weeks prior to allergy testing.

医薬品相互作用

NSAIDsMajor

Increased risk of gastrointestinal ulceration

InsulinMajor

Glucocorticoids antagonize the effect of insulin

PhenobarbitalModerate

May accelerate the metabolism of corticosteroids

ItraconazoleModerate

May decrease the metabolism of corticosteroids

AcetazolamideModerate

Increased risk of hypokalaemia

Amphotericin BMajor

Increased risk of hypokalaemia

FurosemideModerate

Increased risk of hypokalaemia

Thiazide diureticsModerate

Increased risk of hypokalaemia

監視

  • Resolution of clinical signs (pruritus, erythema)
  • Signs of skin atrophy or secondary infection
  • Serum electrolytes (especially Sodium and Potassium)
  • Liver enzymes
  • Blood and urine glucose
  • Clinical signs of GI ulceration
  • Thyroid panel (T3, T4) if indicated

薬物動態

吸収

Systemic absorption is rare but possible with long-term use over large areas.

過剰投与

Overdose via topical application is unlikely, but chronic overuse can lead to iatrogenic hyperadrenocorticism (Cushing's syndrome) and HPA axis suppression.

製品

製剤

  • Lotion
  • Wipes
  • Ointment
  • Spray
  • Shampoo
  • Topical cream (0.5%, 1%)
  • Topical solution (1%)
  • Injectable solution (25 mg/ml)
  • Injectable powder for reconstitution (100 mg, 500 mg)
  • Oral tablets (10 mg, 20 mg)

動物用医薬品

  • Corticalm Lotion 1%
  • Sulfodene HC Anti-Itch Lotion 0.5%
  • Zymox Topical Cream/Wipes/Spray 1%
  • Dermacool HC Spray 1%
  • Cort/Astrin Solution 1%
  • Cortisoothe Shampoo

ヒト用医薬品

  • Hydrocortisone Ointment 0.5%, 1%, 2.5%
  • Hydrocortisone Cream 0.5%, 1%
  • Hydrocortisone Spray 1%
  • Efcortesol
  • Solu-cortef
  • Hydrocortisone 10 mg, 20 mg tablets
  • Hydrocortisone 0.5%, 1% creams

規制ステータス

European Union✓ 承認済み処方箋医薬品EMA
🐕 Dogs🐈 Cats

POM (Prescription Only Medicine)

United Kingdom✓ 承認済み処方箋医薬品VMD
🐕 Dogs🐈 Cats

POM-V

規制データなし: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Store at room temperature away from moisture and heat.

飼主向け情報

塗布後は手を洗うか、手袋を着用してください。目に入らないようにしてください。塗布後少なくとも20〜30分間は、ペットが患部を舐めたり噛んだりしないようにしてください。

VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。