ヒドロコルチゾンアセポン酸エステル
Hydrocortisone aceponate
別名: Cortavance · Easotic · HCA · Hydrocortisone 21-acetate 17-propionate
VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
動物種別用量
🌎 NA — North America🌍 EU — Europe
犬
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Pruritic inflammatory skin disease | 2 pumps of spray per 10 cm x 10 cm square of skin (delivers 1.52 μg/cm2) | topical | q24h | 7 days | 🌍 EU |
| Otitis externa | 1 pump (1 ml) per ear | topical | q24h | 5 days | 🌍 EU |
- Pruritic inflammatory skin disease: Cortavance spray
- Otitis externa: Easotic (combination product)
猫
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| General | Dose not established | topical | unknown | unknown | 🌍 EU |
- General: Safety and efficacy not fully established in cats.
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
概要
ヒドロコルチゾンアセポン酸エステルは、獣医療において主に炎症性およびそう痒性皮膚疾患、ならびに急性または再発性外耳炎の管理に使用される強力な外用コルチコステロイドです。
臨床のポイント: ジエステルプロドラッグとして製剤化されているため、皮膚において高い局所抗炎症効果を発揮する一方で、全身への吸収およびグルココルチコイドに関連する典型的な全身性副作用（副腎抑制や肝酵素上昇など）を大幅に最小限に抑えます。
作用機序
Hydrocortisone aceponate is a highly lipophilic pro-drug. Upon application, it penetrates the stratum corneum and is biotransformed by local esterases in the epidermis → hydrocortisone 17-propionate (the active form). It binds to local glucocorticoid receptors to inhibit inflammatory pathways, reducing erythema, pruritus, and swelling, while its rapid local metabolism minimizes systemic distribution.
安全性・警告
禁忌
- Ulcerated skin
- Perforated tympanic membrane (ear drum)
- Cutaneous ulcers
- Known hypersensitivity to corticosteroids
- Concurrent systemic viral or fungal infections
- Use on large surface areas for prolonged periods without veterinary supervision
有害事象
- Epidermal atrophy (with protracted use)
- Aural erythema (otic preparation)
- Transient hearing loss in geriatric dogs (rare, otic preparation)
- Transient local erythema
- Skin thinning or atrophy (rare, usually only with prolonged use)
- Delayed wound healing
- Systemic glucocorticoid effects (extremely rare due to rapid metabolism)
注意事項
Do not use on ulcerated skin or if the ear drum is perforated.
- Growth Warning: Use with caution in dogs <7 months old, as glucocorticoids are known to slow growth.
- Surface Area Limits: The total body surface treated should not exceed a surface corresponding to a treatment of two flanks (from the spine to the mammary chains, including shoulders and thighs).
- Infections: Microbial infections should be treated appropriately prior to use.
- Monitoring: Patients should be monitored appropriately during long-term use to watch for epidermal atrophy or systemic absorption.
医薬品相互作用
Increased risk of local skin atrophy and potential systemic absorption
監視
- Resolution of pruritus and inflammation
- Signs of epidermal atrophy (skin thinning) with prolonged use
- Liver enzyme activities (during long-term use)
- Cortisol response to ACTH stimulation (during long-term use)
- Resolution of pruritus and erythema
- Signs of local skin thinning or atrophy with prolonged use
薬物動態
半減期
吸収
Highly lipophilic; penetrates the epidermis well but systemic absorption is minimal, reducing systemic side effects.
分布
Primarily localized to the epidermal and dermal layers of the skin at the site of application.
代謝
Biotransformed locally in the epidermis to its active form, hydrocortisone 17-propionate.
消失
Cleared locally with minimal systemic circulation.
過剰投与
Massive over-application or protracted use can result in epidermal atrophy (thinning of the skin). While systemic effects (such as increases in liver enzyme activities or depression of cortisol response to ACTH stimulation) are minimized by the pro-drug formulation, they may theoretically occur with significant overdosage or ingestion.
製品
製剤
- Topical spray: 0.584 mg/ml
- Otic suspension: 1.11 mg/ml (combined with miconazole 15.1 mg/ml and gentamicin 1505 IU/ml)
- Topical spray (0.0584%)
- Otic suspension (in combination with miconazole and gentamicin)
動物用医薬品
- Cortavance 76 ml spray (0.584 mg/ml)
- Easotic suspension for ears (1.11 mg/ml hydrocortisone aceponate, 15.1 mg/ml miconazole, 1505 IU/ml gentamicin)
- Cortavance 0.0584% cutaneous spray, solution for dogs
- Easotic ear drops, suspension for dogs (combination with gentamicin and miconazole)
規制ステータス
Approved for veterinary use in dogs.
POM-V classification.
規制データなし: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
保管・安定性
Normal precautions should be observed. Store at room temperature and keep out of reach of children.
飼主向け情報
獣医師の指示通りに正確にこの薬を使用してください。
- 開いた傷口や潰瘍のある皮膚には使用しないでください。
- 点耳薬を使用する場合、治療を開始する前に獣医師が鼓膜に異常がないことを確認する必要があります。
- 目や口の近くへの噴霧は避けてください。
- 薬を塗布した後は手を洗うか、手袋を着用してください。
- 耳に赤みが見られる場合、皮膚が異常に薄くなっているように見える場合、または高齢の犬が耳が聞こえにくそうにしている場合は、獣医師に連絡してください。
VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。