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3% 過酸化水素 (オキシドール)

Hydrogen Peroxide 3%

Hydrogen peroxide

経口催吐薬 / 局所消毒薬POtopical犬猫フェレット豚

別名: Hydrogen Peroxide 3% Solution · Dilute hydrogen peroxide solution · Hydrogen peroxide solution 10-volume · Hydrogen peroxide topical solution

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

1 teaspoon (5 mL) per 5 lbs. (2.3 kg) of body weight (approximately 2 mL/kg) not to exceed 3 tablespoons (45 mL).PO· can be repeated once if not initially successful
— 🐕

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応用量経路頻度期間地域
As an emetic1 teaspoon (5 mL) per 5 lbs. (2.3 kg) of body weight (approximately 2 mL/kg) not to exceed 3 tablespoons (45 mL).POcan be repeated once if not initially successful—🌎 NA
As an emetic1-2 mL/kg PO up to 2-3 timesPOup to 2-3 times—🌎 NA
As an emetic1-5 mL/kg PO; generally not to exceed 50 mL for dogs and 10 mL for cats; may repeat one time if after 10 minutes emesis does not occur.POmay repeat one time if after 10 minutes emesis does not occur—🌎 NA
  • As an emetic: Vomiting usually occurs within minutes.
  • As an emetic: Inducing emesis is most effective if administered after a small meal.

猫

適応用量経路頻度期間地域
As an emetic1 teaspoon (5 mL) per 5 lbs. (2.3 kg) of body weight (approximately 2 mL/kg) not to exceed 3 tablespoons (45 mL).POcan be repeated once if not initially successful—🌎 NA
As an emetic1-2 mL/kg PO up to 2-3 timesPOup to 2-3 times—🌎 NA
As an emetic1-5 mL/kg PO; generally not to exceed 50 mL for dogs and 10 mL for cats; may repeat one time if after 10 minutes emesis does not occur.POmay repeat one time if after 10 minutes emesis does not occur—🌎 NA
  • As an emetic: Vomiting usually occurs within minutes. Note: Use in cats is generally discouraged due to risk of severe gastric ulceration.
  • As an emetic: Inducing emesis is most effective if administered after a small meal.

フェレット

適応用量経路頻度期間地域
As an emetic1 teaspoon (5 mL) per 5 lbs. (2.3 kg) of body weight (approximately 2 mL/kg) not to exceed 3 tablespoons (45 mL).POcan be repeated once if not initially successful—🌎 NA
As an emetic1-2 mL/kg PO up to 2-3 timesPOup to 2-3 times—🌎 NA
As an emetic1-5 mL/kg PO; may repeat one time if after 10 minutes emesis does not occur.POmay repeat one time if after 10 minutes emesis does not occur—🌎 NA
  • As an emetic: Vomiting usually occurs within minutes.
  • As an emetic: Inducing emesis is most effective if administered after a small meal.

豚

適応用量経路頻度期間地域
As an emetic (pot-bellied pigs)1 teaspoon (5 mL) per 5 lbs. (2.3 kg) of body weight (approximately 2 mL/kg) not to exceed 3 tablespoons (45 mL).POcan be repeated once if not initially successful—🌎 NA
As an emetic (pot-bellied pigs)1-2 mL/kg PO up to 2-3 timesPOup to 2-3 times—🌎 NA
As an emetic (pot-bellied pigs)1-5 mL/kg PO; may repeat one time if after 10 minutes emesis does not occur.POmay repeat one time if after 10 minutes emesis does not occur—🌎 NA
  • As an emetic (pot-bellied pigs): Vomiting usually occurs within minutes.
  • As an emetic (pot-bellied pigs): Inducing emesis is most effective if administered after a small meal.

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

診察中ですか？VetSheet の AI が薬剤・用量・投与期間を構造化された診察記録に直接記入します。VetSheet の仕組みを見る

概要

3%過酸化水素は広く利用されている局所消毒薬であり、獣医療においては主に犬の​緊急経口催吐薬​として頻繁に使用されます。

  • ​臨床のポイント:​ 家庭の常備薬ですが、催吐薬としての使用は通常、すぐに獣医師の診察を受けられず、迅速な除染が必要な状況に限られます。臨床現場では、有効性が高く重度の粘膜刺激リスクが低い、​アポモルヒネ​（犬用）や​キシラジン/デクスメデトミジン​（猫用）などの中枢性催吐薬が推奨されます。
  • ​猫への注意:​ 重度の壊死性出血性胃炎を引き起こすリスクが高いため、毒物学者は猫への使用を推奨していません。
  • ​有効性:​ 催吐に成功しても、胃の内容物が完全に空になったとは限りません。摂取した薬物や毒素のかなりの量が残っているか、すでに吸収されている可能性があります。

作用機序

Orally administered hydrogen peroxide (3%) induces a vomiting reflex via direct irritant effects on the oropharynx and gastric lining.

  • ​Mechanism:​ H₂O₂ interacts with the enzyme catalase present in tissue and blood → rapid release of water (H₂O) and oxygen gas (O₂) → massive bubbling and gastric distension.
  • The combination of direct mucosal irritation and sudden gastric distension stimulates visceral afferent vagal and sympathetic nerves → signals the emetic center in the medulla oblongata → triggers the vomiting reflex.
  • Emesis typically ensues within 10 minutes of administration.

安全性・警告

禁忌

  • Animals already vomiting
  • Severely lethargic, comatose, or debilitated animals (e.g., respiratory distress, decreased swallowing reflex, bradycardia)
  • Seizuring or hyperactive animals
  • Recent abdominal surgery
  • Megaesophagus
  • Ingestion of corrosives/caustics (e.g., acids, alkalis)
  • Ingestion of sharp objects
  • Ingestion of bagged illicit drugs
  • Ingestion of hydrocarbons or petroleum distillates
  • Rodents or rabbits (incapable of vomiting)

有害事象

  • Aspiration of hydrogen peroxide solution or stomach contents
  • Vasovagal (bradycardic) response in animals with cardiovascular compromise
  • Gastric ulceration (particularly in cats)
  • Gastric-dilatation-volvulus (GDV) in dogs

注意事項

​WARNING:​ Do not induce emesis in animals that lack a normal swallowing reflex or are severely depressed due to high aspiration risk.

  • ​Neurological Status:​ Use caution when attempting to induce emesis in a dog that has ingested a compound that can cause seizures or CNS depression, as CNS status may rapidly deteriorate.
  • ​Timeframe:​ Administration and emesis generally must occur within 4 hours (some say 2 hours or 6 hours maximum) of the toxic ingestion.
  • ​Product Safety:​ If home administration is necessary, ensure clients use ONLY the 3% medical grade solution. Higher concentrations are highly corrosive.
  • ​Monitoring:​ Because aspiration and/or bradycardia are possible, animals should be closely observed. Suctioning, respiratory, and cardiovascular support (e.g., atropine) should be available in a clinical setting.
  • ​Re-ingestion:​ Do not allow the animal to re-ingest vomitus.

医薬品相互作用

ACETYLCYSTEINE (oral)

Hydrogen peroxide can oxidize acetylcysteine in the gut; alternative emetics are preferred for acetaminophen overdoses.

ANTIEMETICS (e.g., ondansetron, maropitant)

Preadministration or ingestion of these products may negate the emetic effects of hydrogen peroxide.

監視

  • Efficacy (emesis, signs associated with toxicity of the substance ingested, blood levels of toxicants if applicable)
  • Heart rate and respiration rate
  • Thoracic auscultation after emesis (to monitor for aspiration pneumonia)

過剰投与

Hydrogen peroxide 3% solution is relatively non-toxic after oral ingestion, though it can cause gastric irritation, vomiting, and rarely gastric ulceration or GDV.

​DANGER:​ Hydrogen peroxide in concentrations of 10% or greater (such as hair bleach or industrial peroxide) can be very corrosive, causing severe burns to the oral and gastric mucosa, and can induce fatal oxygen emboli after oral ingestion.

製品

製剤

  • 3% solution (2.5-3.5% w/v)

動物用医薬品

  • None as an oral emetic

ヒト用医薬品

  • Hydrogen Peroxide 3% Solution (OTC, usually sold in pint bottles)

規制ステータス

規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Store 3% solutions in airtight containers at room temperature and protected from light. Hydrogen peroxide 3% can deteriorate with time; outdated or improperly stored products may not be effective as an emetic.

飼主向け情報

​緊急時のみ使用:​ 獣医師やペット中毒管理センターに相談せずに、絶対に吐かせないでください。一部の毒物（電池、漂白剤、鋭利なものなど）は、吐き出す際に深刻なダメージを与えます！

  • ​正しい製品を使用する:​ 必ず標準の​3%過酸化水素（オキシドール）​を使用してください。高濃度（ヘアカラー剤など）は非常に危険で腐食性があります。
  • ​投与方法:​ 投薬用シリンジやスポイトを使用して、口の横から液体を注入します。ペットが液体を肺に吸い込まないように、無理に喉の奥に流し込まないでください。
  • ​プロのアドバイス:​ 過酸化水素を与える直前に、少量の湿った食事（パン一切れや少量の缶詰など）を与えると、胃が押し出すものができ、嘔吐の可能性が高まります。投与後に犬を歩かせると、胃の中で過酸化水素が混ざりやすくなります。
  • ​事後ケア:​ ペットから目を離さないでください。吐いたものを再び食べさせないでください。獣医師が検査できるように、吐瀉物のサンプルをビニール袋や容器に集めてください。

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