ヒプロメロース
ヒプロメロースは、三層構造の涙液膜の水層成分を補うために使用されるセルロースベースの水性人工涙液です。涙液模倣薬として働き、眼に潤いを与え、乾燥を和らげます。 **臨床のポイント：** 動物の乾性角結膜炎（KCS、ドライアイ）の管理に頻繁に使用され、シクロスポリンやタクロリムスなどの局所用涙液分泌促進薬と併用されることがよくあります。水性の代替品であるため、粘度の高い軟膏やゲルと比較して頻繁な点眼が必要です。
作用機序: Hypromellose is a hydrophilic polymer that acts as a **lacrimomimetic**. It increases the viscosity of tears and prolongs corneal contact time. Cellulose-based polymer → binds to existing tears → stabilizes the aqueous layer of the trilaminar tear film → prevents rapid tear evaporation and provides mechanical lubrication to the cornea and conjunctiva.
動物種別の用量
- Keratoconjunctivitis sicca (dry eye) / Ocular lubrication · 1-2 drops per affected eye · Topical (Ophthalmic) · q4h to q12h (or as frequently as needed) · Ongoing · Frequency depends on the severity of dry eye. May be used as often as every 1-2 hours in severe cases.
- Ocular lubrication (e.g., during anesthesia or for exophthalmos) · 1 drop per eye · Topical (Ophthalmic) · As needed · Ongoing · Useful to prevent corneal desiccation during anesthesia.
- Ocular lubrication · 1-2 drops per affected eye · Topical (Ophthalmic) · q4h to q12h (or as frequently as needed) · Ongoing · Frequency depends on the severity of dry eye.
用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。
投与経路
禁忌
- Hypersensitivity to hypromellose or any component of the formulation (such as preservatives like benzalkonium chloride in multi-dose bottles)
有害事象
- Transient blurred vision immediately after application
- Mild ocular irritation or stinging (rare)
- Crusting on the eyelids from dried polymer
薬物相互作用
- Other topical ophthalmic medications · May wash out other eye drops if administered simultaneously. Hypromellose can also act as a barrier if applied before other drugs. · minor
モニタリング
- Resolution of clinical signs of dry eye (e.g., redness, mucoid discharge, blepharospasm)
- Schirmer Tear Test (STT) if managing KCS
- Corneal staining (fluorescein) to monitor for corneal ulceration secondary to dry eye
過量投与
Overdosage is highly unlikely due to the topical route of administration and lack of systemic absorption. Excess drops will simply overflow from the eye.
VetSheet の薬剤リファレンスは、獣医療従事者向けの臨床意思決定支援を目的としており、専門的判断やメーカーの最新添付文書に代わるものではありません。