イバフロキサシン
Ibafloxacin
別名: Ibaflin · S-25030
VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
動物種別用量
🌎 NA — North America🌍 EU — Europe
犬
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Susceptible infections (dermal infections: superficial and deep pyoderma, wounds, abscesses) | 15 mg/kg PO once daily | PO | q24h | Usually a 10-day course is sufficient. In cases of deep pyoderma, reconsider treatment if sufficient improvement not seen in 21 days. | 🌎 NA |
- Susceptible infections (dermal infections: superficial and deep pyoderma, wounds, abscesses): Give at time of feeding. Reconsider treatment if no improvement after 5 days.
猫
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Susceptible infections (dermal infections: soft tissue infections-wounds, abscesses; upper respiratory tract infections) | 15 mg/kg PO once daily | PO | q24h | Usually a 10-day course is sufficient. | 🌎 NA |
- Susceptible infections (dermal infections: soft tissue infections-wounds, abscesses; upper respiratory tract infections): Give at time of feeding. Reconsider treatment if no improvement after 5 days.
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
概要
イバフロキサシンは、主に欧州で使用される獣医専用の経口フルオロキノロン系抗生物質です（米国では未承認）。グラム陰性菌および一部のグラム陽性菌（腸内細菌科、ブドウ球菌など）に対して濃度依存的な殺菌作用を示します。
臨床上のポイント: 他のフルオロキノロン系（エンロフロキサシンやマルボフロキサシンなど）とは異なり、緑膿菌、レンサ球菌、プロテウス・ミラビリスに対する有効性は低いです。
猫における網膜毒性の報告がない点は、同系統の他の薬剤と比較して大きな利点です。
作用機序
Fluoroquinolones exert their bactericidal effect by targeting essential bacterial enzymes involved in DNA replication and transcription.
- Primary Target: Inhibits bacterial DNA-gyrase (topoisomerase II) → prevents DNA supercoiling → halts DNA synthesis.
- Secondary Target: Inhibits topoisomerase IV → interferes with the separation of interlinked replicated DNA molecules.
Ibafloxacin is metabolized into two active metabolites (8-hydroxy-ibafloxacin and 7-hydroxy-ibafloxacin), which contribute to its overall antimicrobial efficacy.
安全性・警告
禁忌
- Dogs less than 8 months of age
- Giant breed dogs less than 18 months of age
- Cats less than 8 months of age
- Known quinolone hypersensitivity
有害事象
- Diarrhea
- Soft feces
- Vomiting
- Dullness
- Anorexia
- Salivation
- Elevated hepatic enzymes (rare, class effect)
- Ataxia (rare, class effect)
- Seizures (rare, class effect)
- Depression/Lethargy (rare, class effect)
- Nervousness (rare, class effect)
注意事項
Use should be based upon susceptibility testing. Safety has not been established in pregnant cats or in lactating dogs and cats, though the UK label states it can be used during pregnancy in dogs. Use with caution in patients with central nervous system disorders.
医薬品相互作用
Should not be used with NSAIDs in dogs with a history of seizures due to increased risk of CNS stimulation.
Cations may bind to ibafloxacin and prevent its gastrointestinal absorption.
Fluoroquinolones may exacerbate the nephrotoxicity of systemic cyclosporine.
May antagonize the antimicrobial activity of fluoroquinolones; concomitant use is not recommended.
Increased risk for cardiotoxicity.
May inhibit absorption of ibafloxacin; separate doses by at least 2 hours.
Ibafloxacin may increase theophylline blood levels.
監視
- Clinical efficacy
- Adverse GI effects (vomiting, hypersalivation, diarrhea, anorexia)
薬物動態
半減期
吸収
Dogs: Oral bioavailability is 70-80% with peak levels at ~1.5 hours. Cats: Rapidly absorbed; food slightly delays absorption but doubles peak levels and increases AUC compared to fasted administration.
分布
Dogs: Volume of distribution at steady state is 1.1 L/kg. Goats: Vd is 1.65 L/kg.
代謝
Presumably metabolized in the liver to at least two active metabolites: 8-hydroxy-ibafloxacin and 7-hydroxy-ibafloxacin.
消失
Eliminated in both urine and feces as unchanged drug and glucuronidated metabolites. Total clearance in dogs is 8.7 mL/min/kg.
過剰投与
Specific information is limited. It is unlikely an acute overdose would result in signs more serious than anorexia or vomiting.
- Dogs: Doses of 75 mg/kg/day (5X) were apparently well tolerated.
- Cats: Doses up to 75 mg/kg/day demonstrated salivation and vomiting. If overdose occurs in cats, ophthalmic monitoring is recommended as a precaution, despite no reported ocular toxicity.
製品
製剤
- Oral gel (3%, 7.5%)
- Tablets (30 mg, 150 mg, 300 mg, 900 mg)
動物用医薬品
- Ibaflin 3% Oral Gel (30 mg ibafloxacin per gram of gel; 30.9 mg/mL) in 15 mL dial syringes
- 7.5% oral gel
- Tablets: 30 mg, 150 mg, 300 mg, 900 mg
規制ステータス
規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
保管・安定性
The oral gel should not be stored at temperatures more than 25°C. Once opened, it is recommended that the syringe be used within 8 weeks. Dispose of unused product once a course of treatment is completed.
飼主向け情報
- 投与方法: この薬は食事と一緒に与えてください。
- 最後まで飲ませる: ペットが元気になったように見えても、処方された期間は必ず最後まで飲ませてください。途中でやめると耐性菌が発生する原因になります。
- 副作用: 軽度の胃腸障害（嘔吐、下痢、よだれ、食欲不振）に注意してください。症状が重い場合や長引く場合は、すぐに獣医師に連絡してください。
- 保管方法: 経口ゲルは室温（25℃以下）で保管し、開封後8週間経過した残りの薬は廃棄してください。
VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。